Cited 56 times in
Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study
DC Field | Value | Language |
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dc.contributor.author | 최영철 | - |
dc.date.accessioned | 2015-01-06T17:20:40Z | - |
dc.date.available | 2015-01-06T17:20:40Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99803 | - |
dc.description.abstract | BACKGROUND AND PURPOSE: No previous studies have investigated the relationship between various anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance. METHODS: Serum was collected from patients during the acute phase of GBS at 20 university-based hospitals in Korea. The clinical and laboratory findings were reviewed and compared with the detected types of anti-ganglioside antibody. RESULTS: Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presence of preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence of cranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantly male, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- or anti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study. CONCLUSIONS: Anti-ganglioside antibodies were frequently found in the serum of Korean GBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequently misdiagnosed as AIDP by single electrophysiological studies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 94~100 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Prevalence of Anti-Ganglioside Antibodies and Their Clinical Correlates with Guillain-Barre Syndrome in Korea: A Nationwide Multicenter Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학) | - |
dc.contributor.googleauthor | Jong Kuk Kim | - |
dc.contributor.googleauthor | Jong Seok Bae | - |
dc.contributor.googleauthor | Dae-Seong Kim | - |
dc.contributor.googleauthor | Susumu Kusunoki | - |
dc.contributor.googleauthor | Jong Eun Kim | - |
dc.contributor.googleauthor | Ji Soo Kim | - |
dc.contributor.googleauthor | Young-Eun Park | - |
dc.contributor.googleauthor | Ki-Jong Park | - |
dc.contributor.googleauthor | Hyun Seok Song | - |
dc.contributor.googleauthor | Sun Young Kim | - |
dc.contributor.googleauthor | Jeong-Geun Lim | - |
dc.contributor.googleauthor | Nam-Hee Kim | - |
dc.contributor.googleauthor | Bum Chun Suh | - |
dc.contributor.googleauthor | Tai-Seung Nam | - |
dc.contributor.googleauthor | Min Su Park | - |
dc.contributor.googleauthor | Young-Chul Choi | - |
dc.contributor.googleauthor | Eun Hee Sohn | - |
dc.contributor.googleauthor | Sang-Jun Na | - |
dc.contributor.googleauthor | So Young Huh | - |
dc.contributor.googleauthor | Ohyun Kwon | - |
dc.contributor.googleauthor | Su-Yun Lee | - |
dc.contributor.googleauthor | Sung-Hoon Lee | - |
dc.contributor.googleauthor | Sun-Young Oh | - |
dc.contributor.googleauthor | Seong-Hae Jeong | - |
dc.contributor.googleauthor | Tae-Kyeong Lee | - |
dc.contributor.googleauthor | Dong Uk Kim | - |
dc.identifier.doi | 10.3988/jcn.2014.10.2.94 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04116 | - |
dc.relation.journalcode | J01327 | - |
dc.identifier.eissn | 2005-5013 | - |
dc.identifier.pmid | 24829594 | - |
dc.subject.keyword | Guillain-Barré syndrome | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | acute motor axonal neuropathy | - |
dc.subject.keyword | antibodies | - |
dc.subject.keyword | ganglioside | - |
dc.contributor.alternativeName | Choi, Young Chul | - |
dc.contributor.affiliatedAuthor | Choi, Young Chul | - |
dc.citation.volume | 10 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 94 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, Vol.10(2) : 94-100, 2014 | - |
dc.identifier.rimsid | 49610 | - |
dc.type.rims | ART | - |
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