Cited 21 times in
Outcome of Local Excision Following Preoperative Chemoradiotherapy for Clinically 12 Distal Rectal Cancer: A Multicenter Retrospective Study (KROG 12-06)
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금웅섭 | - |
dc.date.accessioned | 2015-01-06T17:20:28Z | - |
dc.date.available | 2015-01-06T17:20:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99797 | - |
dc.description.abstract | PURPOSE: The aim of this study was to examine the clinical implications of a pathologically complete response after neoadjuvant chemoradiotherapy (CRT) followed by local excision for patients with cT2 rectal cancer who refused radical surgery. MATERIALS AND METHODS: Seventeen patients with cT2 primary rectal cancer within 6 cm from the anal verge who received neoadjuvant CRT and local excision because of patient refusal of radical surgery or poor performance status were included. Two patients had clinical involvement of a regional lymph node. Preoperative radiotherapy was delivered to the whole pelvis at a dose of 44 to 50.4 Gy in 22 to 28 fractions. All patients underwent transanal excision and eight patients (47%) received postoperative chemotherapy. RESULTS: Ten patients (59%) achieved ypT0. At a median follow-up period of 75 months (range, 22 to 126 months), four (24%) patients developed recurrence (two locoregional and two distant). The 5-year disease-free survival of all patients was 82%, and was higher in patients with ypT0 (90%) than in patients with ypT1-2 (69%, p=0.1643). Decreased disease-free survival was also observed in patients receiving capecitabine compared with 5-fluorouracil (54% vs. 100%, p=0.0298). CONCLUSION: Local excision could be a feasible alternative to radical surgery in patients with ypT0 after neoadjuvant CRT for cT2 distal rectal cancer without further radical surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 243~249 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Outcome of Local Excision Following Preoperative Chemoradiotherapy for Clinically 12 Distal Rectal Cancer: A Multicenter Retrospective Study (KROG 12-06) | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Jae Myoung Noh | - |
dc.contributor.googleauthor | Won Park | - |
dc.contributor.googleauthor | Jae-Sung Kim | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Jin Hee Kim | - |
dc.contributor.googleauthor | Doo Ho Choi | - |
dc.contributor.googleauthor | Hee Chul Park | - |
dc.identifier.doi | 10.4143/crt.2014.46.3.243 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00273 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 25038759 | - |
dc.subject.keyword | Rectal neoplasms | - |
dc.subject.keyword | Neoadjuvant therapy | - |
dc.subject.keyword | Local excision | - |
dc.subject.keyword | Complete remission | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 243 | - |
dc.citation.endPage | 249 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.46(3) : 243-249, 2014 | - |
dc.identifier.rimsid | 49606 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.