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Outcome of Local Excision Following Preoperative Chemoradiotherapy for Clinically 12 Distal Rectal Cancer: A Multicenter Retrospective Study (KROG 12-06)

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.date.accessioned2015-01-06T17:20:28Z-
dc.date.available2015-01-06T17:20:28Z-
dc.date.issued2014-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99797-
dc.description.abstractPURPOSE: The aim of this study was to examine the clinical implications of a pathologically complete response after neoadjuvant chemoradiotherapy (CRT) followed by local excision for patients with cT2 rectal cancer who refused radical surgery. MATERIALS AND METHODS: Seventeen patients with cT2 primary rectal cancer within 6 cm from the anal verge who received neoadjuvant CRT and local excision because of patient refusal of radical surgery or poor performance status were included. Two patients had clinical involvement of a regional lymph node. Preoperative radiotherapy was delivered to the whole pelvis at a dose of 44 to 50.4 Gy in 22 to 28 fractions. All patients underwent transanal excision and eight patients (47%) received postoperative chemotherapy. RESULTS: Ten patients (59%) achieved ypT0. At a median follow-up period of 75 months (range, 22 to 126 months), four (24%) patients developed recurrence (two locoregional and two distant). The 5-year disease-free survival of all patients was 82%, and was higher in patients with ypT0 (90%) than in patients with ypT1-2 (69%, p=0.1643). Decreased disease-free survival was also observed in patients receiving capecitabine compared with 5-fluorouracil (54% vs. 100%, p=0.0298). CONCLUSION: Local excision could be a feasible alternative to radical surgery in patients with ypT0 after neoadjuvant CRT for cT2 distal rectal cancer without further radical surgery.-
dc.description.statementOfResponsibilityopen-
dc.format.extent243~249-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOutcome of Local Excision Following Preoperative Chemoradiotherapy for Clinically 12 Distal Rectal Cancer: A Multicenter Retrospective Study (KROG 12-06)-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorJae Myoung Noh-
dc.contributor.googleauthorWon Park-
dc.contributor.googleauthorJae-Sung Kim-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorDoo Ho Choi-
dc.contributor.googleauthorHee Chul Park-
dc.identifier.doi10.4143/crt.2014.46.3.243-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00273-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid25038759-
dc.subject.keywordRectal neoplasms-
dc.subject.keywordNeoadjuvant therapy-
dc.subject.keywordLocal excision-
dc.subject.keywordComplete remission-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.citation.volume46-
dc.citation.number3-
dc.citation.startPage243-
dc.citation.endPage249-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.46(3) : 243-249, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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