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Pediatric Patients with Refractory Central Nervous System Tumors: Experiences of a Clinical Trial Combining Bevacizumab and Temsirolimus

Authors
 SARINA A. PIHA-PAUL  ;  SANG JOON SHIN  ;  TRIBHAWAN VATS  ;  NANDITA GUHA-THAKURTA  ;  JOANN AARON  ;  MICHAEL RYTTING  ;  EUGENIE KLEINERMAN  ;  RAZELLE KURZROCK 
Citation
 Anticancer Research, Vol.34(4) : 1939-1945, 2014 
Journal Title
 Anticancer Research 
ISSN
 0250-7005 
Issue Date
2014
Abstract
BACKGROUND: Pre-clinical findings suggest that combination treatment with bevacizumab and temsirolimus could be effective against malignant pediatric central nervous system (CNS) tumors. PATIENTS AND METHODS: Six pediatric patients were treated as part of a phase I trial with intravenous temsirolimus 25 mg on days 1, 8, 15, and bevacizumab at 5, 10, or 15 mg/kg on day 1 of each 21-day cycle until disease progression or patient withdrawal. RESULTS: The median patient age was six years (range=3-14 years). The primary diagnoses were glioblastoma multiforme (n=2), medullobalstoma (n=2), pontine glioma (n=1) and ependymoma (n=1). All patients had disease refractory to standard-of-care (2-3 prior systemic therapies). Grade 3 toxicities possibly related to drugs used occurred in two patients: anorexia, nausea, and weight loss in one, and thrombocytopenia and alanine aminotransferase elevation in another. One patient with glioblastoma multiforme achieved a partial response (51% regression) and two patients (with medulloblastoma and pontine glioma) had stable disease for four months or more (20 and 47 weeks, respectively). One other patient (with glioblastoma multiforme) showed 18% tumor regression (duration=12 weeks). CONCLUSION: The combination of bevacizumab with temsirolimus was well-tolerated and resulted in stable disease of at least four months/partial response in three out of six pediatric patients with chemorefractory CNS tumors.
Full Text
http://ar.iiarjournals.org/content/34/4/1939.long
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
신상준(Shin, Sang Joon) ORCID logo https://orcid.org/0000-0001-5350-7241
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/99793
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