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High prevalence of spine-femur bone mineral density discordance and comparison of vertebral fracture risk assessment using femoral neck and lumbar spine bone density in Korean patients

DC FieldValueLanguage
dc.contributor.author김경민-
dc.contributor.author석한나-
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.contributor.author차봉수-
dc.contributor.author김광준-
dc.date.accessioned2015-01-06T17:19:40Z-
dc.date.available2015-01-06T17:19:40Z-
dc.date.issued2014-
dc.identifier.issn0914-8779-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99772-
dc.description.abstractThe aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 and December 2005 were enrolled in this study. Vertebral fracture risk was calculated using initial FN and LS BMD. The follow-up vertebral X-rays from all subjects were reviewed, and the calculated estimated risk using the Fracture Risk Assessment Tool (FRAX®) was compared with the actual prevalence of vertebral fractures during the follow-up period. Among a total of 443 women with a mean age of 58.5 years, 130 women (29.3 %) demonstrated femur–spine discordance (i.e., a difference between FN and LS BMD of >1 SD). Most subjects having discordance showed lower LS BMD (73.1 %) compared to FN BMD. During the mean 7-year follow-up period, 12 (2.7 %) vertebral fractures occurred. In cases with high estimated fracture risk (>20 % for estimated fracture risk), using LS BMD significantly reflected the actual vertebral fracture in total subjects [odds ratio (OR) 19.29, 95 % confidence interval (CI) 4.21–88.46], in subjects with spine–femur discordance (OR 16.00, 95 % CI 1.91–134.16), and in subjects with spine–femur discordance having lower LS BMD (OR 20.67, 95 % CI 1.63–262.71). In comparison, the estimated risk using FN BMD did not reflect the actual occurrence of vertebral fractures. In conclusion, a significant number of Korean subjects exhibited spine–femur discordance, and LS BMD might be more appropriate for estimation of vertebral fracture risk.-
dc.description.statementOfResponsibilityopen-
dc.format.extent405~410-
dc.relation.isPartOfJournal of Bone and Mineral Metabolism-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBone Density/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHFemur Neck/diagnostic imaging*-
dc.subject.MESHHumans-
dc.subject.MESHKorea-
dc.subject.MESHLumbar Vertebrae/diagnostic imaging*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRadiography-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSpinal Fractures/diagnostic imaging*-
dc.titleHigh prevalence of spine-femur bone mineral density discordance and comparison of vertebral fracture risk assessment using femoral neck and lumbar spine bone density in Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHannah Seok-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi10.1007/s00774-013-0512-3-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00295-
dc.contributor.localIdA01930-
dc.contributor.localIdA03012-
dc.contributor.localIdA03375-
dc.contributor.localIdA03996-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ01277-
dc.identifier.pmid24122250-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00774-013-0512-3-
dc.subject.keywordOsteoporosis-
dc.subject.keywordVertebral fracture-
dc.subject.keywordBone mineral density-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.alternativeNameSeok, Hannah-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Kyung Min-
dc.contributor.affiliatedAuthorSeok, Hannah-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.rights.accessRightsfree-
dc.citation.volume32-
dc.citation.number4-
dc.citation.startPage405-
dc.citation.endPage410-
dc.identifier.bibliographicCitationJournal of Bone and Mineral Metabolism, Vol.32(4) : 405-410, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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