394 677

Cited 42 times in

Incidence and Risk Factors of Postoperative Nausea and Vomiting in Patients with Fentanyl-Based Intravenous Patient-Controlled Analgesia and Single Antiemetic Prophylaxis

DC Field Value Language
dc.contributor.author심연희-
dc.contributor.author이윤우-
dc.contributor.author이정수-
dc.contributor.author장철호-
dc.contributor.author최종범-
dc.date.accessioned2015-01-06T17:19:19Z-
dc.date.available2015-01-06T17:19:19Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99761-
dc.description.abstractPURPOSE: We evaluated the incidence and risk factors of postoperative nausea and vomiting (PONV) in patients with fentanyl-based intravenous patient-controlled analgesia (IV-PCA) and single antiemetic prophylaxis of 5-hydroxytryptamine type 3 (5 HT₃)-receptor antagonist after the general anesthesia. MATERIALS AND METHODS: In this retrospective study, incidence and risk factors for PONV were evaluated with fentanyl IV-PCA during postoperative 48 hours after various surgeries. RESULTS: Four hundred-forty patients (23%) of 1878 had showed PONV. PCA was discontinued temporarily in 268 patients (14%), mostly due to PONV (88% of 268 patients). In multivariate analysis, female, non-smoker, history of motion sickness or PONV, long duration of anesthesia (>180 min), use of desflurane and intraoperative remifentanil infusion were independent risk factors for PONV. If one, two, three, four, five, or six of these risk factors were present, the incidences of PONV were 18%, 19%, 22%, 31%, 42%, or 50%. Laparoscopic surgery and higher dose of fentanyl were not risk factors for PONV. CONCLUSION: Despite antiemetic prophylaxis with 5 HT₃-receptor antagonist, 23% of patients with fentanyl-based IV-PCA after general anesthesia showed PONV. Long duration of anesthesia and use of desflurane were identified as risk factors, in addition to risk factors of Apfel's score (female, non-smoker, history of motion sickness or PONV). Also, intraoperative remifentanil infusion was risk factor independent of postoperative opioid use. As the incidence of PONV was up to 50% according to the number of risk factors, risk-adapted, multimodal or combination therapy should be applied.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1430~1435-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnalgesia, Patient-Controlled/adverse effects*-
dc.subject.MESHAnalgesics, Opioid/adverse effects*-
dc.subject.MESHAnalgesics, Opioid/therapeutic use-
dc.subject.MESHAntiemetics/administration & dosage-
dc.subject.MESHAntiemetics/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHFentanyl/adverse effects*-
dc.subject.MESHFentanyl/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHIsoflurane/adverse effects-
dc.subject.MESHIsoflurane/analogs & derivatives*-
dc.subject.MESHIsoflurane/therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPiperidines/adverse effects*-
dc.subject.MESHPiperidines/therapeutic use-
dc.subject.MESHPostoperative Nausea and Vomiting/chemically induced-
dc.subject.MESHPostoperative Nausea and Vomiting/epidemiology*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.titleIncidence and Risk Factors of Postoperative Nausea and Vomiting in Patients with Fentanyl-Based Intravenous Patient-Controlled Analgesia and Single Antiemetic Prophylaxis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJong Bum Choi-
dc.contributor.googleauthorYon Hee Shim-
dc.contributor.googleauthorYoun-Woo Lee-
dc.contributor.googleauthorJeong Soo Lee-
dc.contributor.googleauthorJong-Rim Choi-
dc.contributor.googleauthorChul Ho Chang-
dc.identifier.doi10.3349/ymj.2014.55.5.1430-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02196-
dc.contributor.localIdA03022-
dc.contributor.localIdA03109-
dc.contributor.localIdA03485-
dc.contributor.localIdA04183-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid25048507-
dc.subject.keywordAnalgesia-
dc.subject.keywordantiemetics-
dc.subject.keywordfentanyl-
dc.subject.keywordpatient-controlled-
dc.subject.keywordpostoperative nausea and vomiting-
dc.contributor.alternativeNameShim, Yon Hee-
dc.contributor.alternativeNameLee, Youn Woo-
dc.contributor.alternativeNameLee, Jeong Soo-
dc.contributor.alternativeNameChang, Chul Ho-
dc.contributor.alternativeNameChoi, Jong Bum-
dc.contributor.affiliatedAuthorShim, Yon Hee-
dc.contributor.affiliatedAuthorLee, Youn Woo-
dc.contributor.affiliatedAuthorLee, Jeong Soo-
dc.contributor.affiliatedAuthorChang, Chul Ho-
dc.contributor.affiliatedAuthorChoi, Jong Bum-
dc.citation.volume55-
dc.citation.number5-
dc.citation.startPage1430-
dc.citation.endPage1435-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(5) : 1430-1435, 2014-
dc.identifier.rimsid57101-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.