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Role of induction and consolidation chemotherapy in elderly acute myeloid leukemia patients

DC Field Value Language
dc.contributor.author김수정-
dc.contributor.author민유홍-
dc.contributor.author정준원-
dc.date.accessioned2015-01-06T17:17:30Z-
dc.date.available2015-01-06T17:17:30Z-
dc.date.issued2014-
dc.identifier.issn0925-5710-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99701-
dc.description.abstractThe present study sought to elucidate the role of induction and consolidation therapy in elderly patients. We retrospectively collected data of 477 patients who were aged over 60 years at the time of acute myeloid leukemia (AML) diagnosis. The median overall survival (OS) was 339 days in the induction group (n = 266) and 86 days in the best supportive care group (n = 211) (P < 0.001). In the induction group, the complete remission (CR) rate was 58.3 %, and treatment-related death was 15.4 %. Successful induction was related to good performance [Eastern Cooperative Oncology Group (ECOG <2)] [hazard ratio (HR) 3.215; P = 0.002]. Mortality correlated with failure to achieve CR (HR 4.059; P < 0.001) and poor performance status (ECOG >2) (HR 2.731; P = 0.035). In CR patients, poor karyotype and absence of consolidation (HR 2.313; P = 0.003) correlated with mortality. More than one cycle of consolidation was associated with better OS (P < 0.001). Lack of salvage therapy was associated with mortality in patients who did not achieve CR (HR 3.223; P = 0.005). Intensive induction in patients with good performance and >1 cycle of consolidation after CR may be the best strategy for improving OS in elderly AML patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent141~151-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols*-
dc.subject.MESHConsolidation Chemotherapy/methods*-
dc.subject.MESHCytarabine/administration & dosage-
dc.subject.MESHDaunorubicin/administration & dosage-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIdarubicin/administration & dosage-
dc.subject.MESHKaryotyping-
dc.subject.MESHLeukemia, Myeloid, Acute/drug therapy*-
dc.subject.MESHLeukemia, Myeloid, Acute/mortality-
dc.subject.MESHLeukemia, Myeloid, Acute/pathology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRemission Induction-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSalvage Therapy-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVidarabine/administration & dosage-
dc.subject.MESHVidarabine/analogs & derivatives-
dc.titleRole of induction and consolidation chemotherapy in elderly acute myeloid leukemia patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSoo-Jeong Kim-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorDae-Young Kim-
dc.contributor.googleauthorJe-Hwan Lee-
dc.contributor.googleauthorKyoo-Hyung Lee-
dc.contributor.googleauthorYeo-Kyeoung Kim-
dc.contributor.googleauthorHyeong-Joon Kim-
dc.contributor.googleauthorIk-Chan Song-
dc.contributor.googleauthorDeog-Yeon Jo-
dc.contributor.googleauthorJeong-Ok Lee-
dc.contributor.googleauthorSoo-Mee Bang-
dc.contributor.googleauthorJinny Park-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorWon-Sik Lee-
dc.contributor.googleauthorYoung-Don Joo-
dc.contributor.googleauthorChi Hoon Maeng-
dc.contributor.googleauthorHwi-Joong Yoon-
dc.contributor.googleauthorNa-Ri Lee-
dc.contributor.googleauthorJae-Yong Kwak-
dc.contributor.googleauthorKyoung Ha Kim-
dc.contributor.googleauthorJong-Ho Won-
dc.contributor.googleauthorBo Ram Han-
dc.contributor.googleauthorDae Young Zang-
dc.contributor.googleauthorJoon Ho Moon-
dc.contributor.googleauthorSang Kyun Sohn-
dc.contributor.googleauthorSung Hwa Bae-
dc.contributor.googleauthorHun Mo Ryoo-
dc.contributor.googleauthorSung-Yong Kim-
dc.contributor.googleauthorMark Hong Lee-
dc.contributor.googleauthorYoo Hong Min-
dc.identifier.doi10.1007/s12185-014-1617-8-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00633-
dc.contributor.localIdA01407-
dc.contributor.localIdA03729-
dc.relation.journalcodeJ01120-
dc.identifier.eissn1865-3774-
dc.identifier.pmid24996615-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs12185-014-1617-8-
dc.subject.keywordElderly AML-
dc.subject.keywordInduction-
dc.subject.keywordConsolidation-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.rights.accessRightsfree-
dc.citation.volume100-
dc.citation.number2-
dc.citation.startPage141-
dc.citation.endPage151-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF HEMATOLOGY, Vol.100(2) : 141-151, 2014-
dc.identifier.rimsid57066-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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