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Inhibition of IL-17A Suppresses Enhanced-Tumor Growth in Low Dose Pre-Irradiated Tumor Beds

DC Field Value Language
dc.contributor.author이은정-
dc.contributor.author이익재-
dc.contributor.author서양권-
dc.contributor.author성진실-
dc.date.accessioned2015-01-06T17:14:55Z-
dc.date.available2015-01-06T17:14:55Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99617-
dc.description.abstractIonizing radiation induces modification of the tumor microenvironment such as tumor surrounding region, which is relevant to treatment outcome after radiotherapy. In this study, the effects of pre-irradiated tumor beds on the growth of subsequently implanted tumors were investigated as well as underlying mechanism. The experimental model was set up by irradiating the right thighs of C3H/HeN mice with 5 Gy, followed by the implantation of HCa-I and MIH-2. Both implanted tumors in the pre-irradiated bed showed accelerated-growth compared to the control. Tumor-infiltrated lymphocyte (TIL) levels were increased, as well as pro-tumor factors such as IL-6 and transforming growth factor-beta1 (TGF-β1) in the pre-irradiated group. In particular, the role of pro-tumor cytokine interleukin-17A (IL-17A) was investigated as a possible target mechanism because IL-6 and TGF-β are key factors in Th17 cells differentiation from naïve T cells. IL-17A expression was increased not only in tumors, but also in CD4+ T cells isolated from the tumor draining lymph nodes. The effect of IL-17A on tumor growth was confirmed by treating tumors with IL-17A antibody, which abolished the acceleration of tumor growth. These results indicate that the upregulation of IL-17A seems to be a key factor for enhancing tumor growth in pre-irradiated tumor beds.-
dc.description.statementOfResponsibilityopen-
dc.format.extente106423-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAntibodies, Neutralizing/pharmacology-
dc.subject.MESHCell Differentiation/drug effects-
dc.subject.MESHCell Differentiation/radiation effects-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHCell Proliferation/radiation effects-
dc.subject.MESHDisease Progression-
dc.subject.MESHDose-Response Relationship, Radiation-
dc.subject.MESHInterleukin-17/antagonists & inhibitors*-
dc.subject.MESHInterleukin-17/metabolism-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymph Nodes/radiation effects-
dc.subject.MESHLymphocytes, Tumor-Infiltrating/drug effects-
dc.subject.MESHLymphocytes, Tumor-Infiltrating/immunology-
dc.subject.MESHLymphocytes, Tumor-Infiltrating/radiation effects-
dc.subject.MESHMale-
dc.subject.MESHMice, Inbred C3H-
dc.subject.MESHNeoplasm Transplantation-
dc.subject.MESHNeoplasms/immunology-
dc.subject.MESHNeoplasms/pathology*-
dc.subject.MESHNeoplasms/radiotherapy*-
dc.subject.MESHNeutralization Tests-
dc.subject.MESHRadiation, Ionizing-
dc.subject.MESHTh17 Cells/drug effects-
dc.subject.MESHTh17 Cells/immunology-
dc.subject.MESHTh17 Cells/radiation effects-
dc.subject.MESHTransforming Growth Factor beta/metabolism-
dc.titleInhibition of IL-17A Suppresses Enhanced-Tumor Growth in Low Dose Pre-Irradiated Tumor Beds-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorEun-Jung Lee-
dc.contributor.googleauthorHyo Jin Park-
dc.contributor.googleauthorIk-Jae Lee-
dc.contributor.googleauthorWon Woo Kim-
dc.contributor.googleauthorSang-Jun Ha-
dc.contributor.googleauthorYang-Gun Suh-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1371/journal.pone.0106423-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03047-
dc.contributor.localIdA03055-
dc.contributor.localIdA01891-
dc.contributor.localIdA01956-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25181290-
dc.contributor.alternativeNameLee, Eun Jung-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameSuh, Yang Gun-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Eun Jung-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorSuh, Yang Gun-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.citation.volume9-
dc.citation.number9-
dc.citation.startPagee106423-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(9) : e106423, 2014-
dc.identifier.rimsid38956-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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