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Endothelial Dysfunction Is Associated With Major Adverse Cardiovascular Events in Peritoneal Dialysis Patients

DC Field Value Language
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author윤창연-
dc.contributor.author이미정-
dc.contributor.author최훈영-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author한지숙-
dc.contributor.author강신욱-
dc.contributor.author김은진-
dc.contributor.author박정탁-
dc.contributor.author이정은-
dc.date.accessioned2015-01-06T17:12:40Z-
dc.date.available2015-01-06T17:12:40Z-
dc.date.issued2014-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99543-
dc.description.abstractEndothelial dysfunction is implicated in increased cardiovascular risk in nondialyzed population. However, the prognostic impact of endothelial dysfunction on cardiovascular outcome has not been investigated in peritoneal dialysis (PD) patients. We prospectively determined endothelial function by brachial artery endothelium-dependent vasodilation (flow-mediated dilation [FMD]) in 143 nondiabetic PD patients and 32 controls. Primary outcome was a major adverse cardiac and cerebrovascular event (MACCE). Brachial FMD was significantly lower in PD patients than in controls (2.9% [1.3-4.7] vs 6.2% [5.4-8.3], P < 0.001). During a mean follow-up of 42 months, primary outcome was observed in 25 patients (17.5%). When patients were dichotomized by the median value of FMD (2.9%), incidence rates of MACCEs were significantly higher in the group with lower FMD compared with higher FMD (7.2 vs 3.0/100 person-years, P = 0.03). In multivariate Cox analysis, low FMD (≤2.9%) was a significant independent predictor of MACCEs (hazard ratio = 2.73, 95% confidence interval = 1.03-7.22, P = 0.04). Furthermore, multivariate fractional polynomial analysis showed that the risk of MACCE decreased steadily with higher FMD values. Impaired brachial FMD was a significant independent predictor of MACCEs in PD patients. Estimating endothelial dysfunction by brachial FMD could be useful for stratifying cardiovascular risk in these patients.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBrachial Artery/physiopathology-
dc.subject.MESHCardiovascular Diseases/diagnosis*-
dc.subject.MESHCardiovascular Diseases/physiopathology-
dc.subject.MESHEndothelium, Vascular/physiopathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPeritoneal Dialysis/statistics & numerical data*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSex Factors-
dc.subject.MESHVasodilation/physiology-
dc.titleEndothelial Dysfunction Is Associated With Major Adverse Cardiovascular Events in Peritoneal Dialysis Patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorJung Eun Lee-
dc.contributor.googleauthorHoon Young Choi-
dc.contributor.googleauthorChang-Yun Yoon-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorJi Suk Han-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.1097/MD.0000000000000073-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA02613-
dc.contributor.localIdA04226-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA04327-
dc.contributor.localIdA00053-
dc.contributor.localIdA01654-
dc.contributor.localIdA00823-
dc.contributor.localIdA02773-
dc.contributor.localIdA03119-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid25192486-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00005792-201409010-00004&LSLINK=80&D=ovft-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameYoon, Chang Yun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameChoi, Hoon Young-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameHahn, Jee Sook-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorYoon, Chang Yun-
dc.contributor.affiliatedAuthorChoi, Hoon Young-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorHahn, Jee Sook-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorLee, Jung Eun-
dc.rights.accessRightsfree-
dc.citation.volume93-
dc.citation.number11-
dc.citation.startPage73-
dc.identifier.bibliographicCitationMEDICINE, Vol.93(11) : 73, 2014-
dc.identifier.rimsid39490-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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