Cited 83 times in
A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy
DC Field | Value | Language |
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dc.contributor.author | 신성재 | - |
dc.date.accessioned | 2015-01-06T17:09:07Z | - |
dc.date.available | 2015-01-06T17:09:07Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99433 | - |
dc.description.abstract | A key factor in dendritic cell (DC)-based tumor immunotherapy is the identification of an immunoadjuvant capable of inducing DC maturation to enhance cellular immunity. The efficacy of a 50S ribosomal protein L7/L12 (rplL) from Mycobacterium tuberculosis Rv0652, as an immunoadjuvant for DC-based tumor immunotherapy, and its capacity for inducing DC maturation was investigated. In this study, we showed that Rv0652 is recognized by Toll-like receptor 4 (TLR4) to induce DC maturation, and pro-inflammatory cytokine production (TNF-alpha, IL-1beta, and IL-6) that is partially modulated by both MyD88 and TRIF signaling pathways. Rv0652-activated DCs could activate naïve T cells, effectively polarize CD4+ and CD8+ T cells to secrete IFN-gamma, and induce T cell-mediated-cytotoxicity. Immunization of mice with Rv0652-stimulated ovalbumin (OVA)-pulsed DCs resulted in induction of a potent OVA-specific CD8+ T cell response, slowed tumor growth, and promoted long-term survival in a murine OVA-expressing E.G7 thymoma model. These findings suggest that Rv0652 enhances the polarization of T effector cells toward a Th1 phenotype through DC maturation, and that Rv0652 may be an effective adjuvant for enhancing the therapeutic response to DC-based tumor immunotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adaptor Proteins, Vesicular Transport/genetics | - |
dc.subject.MESH | Adaptor Proteins, Vesicular Transport/immunology | - |
dc.subject.MESH | Adjuvants, Immunologic/chemistry | - |
dc.subject.MESH | Adjuvants, Immunologic/pharmacology* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bacterial Proteins/chemistry | - |
dc.subject.MESH | Bacterial Proteins/pharmacology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cytokines/genetics | - |
dc.subject.MESH | Cytokines/immunology | - |
dc.subject.MESH | Dendritic Cells*/immunology | - |
dc.subject.MESH | Dendritic Cells*/pathology | - |
dc.subject.MESH | Immunity, Cellular/genetics | - |
dc.subject.MESH | Immunity, Cellular/immunology | - |
dc.subject.MESH | Immunotherapy* | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Mycobacterium tuberculosis/chemistry* | - |
dc.subject.MESH | Neoplasms, Experimental*/immunology | - |
dc.subject.MESH | Neoplasms, Experimental*/pathology | - |
dc.subject.MESH | Neoplasms, Experimental*/therapy | - |
dc.subject.MESH | Toll-Like Receptor 4/genetics | - |
dc.subject.MESH | Toll-Like Receptor 4/immunology | - |
dc.title | A potential protein adjuvant derived from Mycobacterium tuberculosis Rv0652 enhances dendritic cells-based tumor immunotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung Jun Lee | - |
dc.contributor.googleauthor | Sung Jae Shin | - |
dc.contributor.googleauthor | Moon Hee Lee | - |
dc.contributor.googleauthor | Min-Goo Lee | - |
dc.contributor.googleauthor | Tae Heung Kang | - |
dc.contributor.googleauthor | Won Sun Park | - |
dc.contributor.googleauthor | Byoung Yul Soh | - |
dc.contributor.googleauthor | Jung Hee Park | - |
dc.contributor.googleauthor | Yong Kyoo Shin | - |
dc.contributor.googleauthor | Han Wool Kim | - |
dc.contributor.googleauthor | Cheol-Heui Yun | - |
dc.contributor.googleauthor | In Duk Jung | - |
dc.contributor.googleauthor | Yeong-Min Park | - |
dc.identifier.doi | 10.1371/journal.pone.0104351 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02113 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 25102137 | - |
dc.contributor.alternativeName | Shin, Sung Jae | - |
dc.contributor.affiliatedAuthor | Shin, Sung Jae | - |
dc.citation.volume | 9 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | e104351 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(8) : e104351, 2014 | - |
dc.identifier.rimsid | 39424 | - |
dc.type.rims | ART | - |
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