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Correlation between Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Endoscopic Activity in Intestinal Behçet's Disease

DC Field Value Language
dc.contributor.author김승원-
dc.contributor.author김원호-
dc.contributor.author김태일-
dc.contributor.author박수정-
dc.contributor.author신혜선-
dc.contributor.author천재희-
dc.contributor.author홍성필-
dc.date.accessioned2015-01-06T17:06:10Z-
dc.date.available2015-01-06T17:06:10Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99350-
dc.description.abstractPURPOSE: The serum levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have recently been shown to be correlated highly with disease activity in patients with intestinal Behçet's disease (BD). However, it remains unclear whether sTREM-1 levels reflect endoscopic activity in intestinal BD. This study aimed to evaluate the correlation of sTREM-1 levels with endoscopic activity in intestinal BD. MATERIALS AND METHODS: A total of 84 patients with intestinal BD were enrolled. Endoscopic activity was compared with sTREM-1 levels as well as other laboratory findings, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). RESULTS: sTREM-1 levels were significantly increased in intestinal BD patients compared with controls (37.98±27.09 pg/mL vs. 16.65±7.76 pg/mL, p=0.002), however, there was no difference between endoscopically quiescent and active diseases (43.53±24.95 pg/mL vs. 42.22±32.68 pg/mL, p=0.819). Moreover, serum sTREM-1 levels did not differ in terms of number, shape, depth, size, margin, or type of ulcer in patients with intestinal BD. However, mean ESR and CRP levels in patients with active disease were significantly higher than those in patients with quiescent disease (p=0.001, p<0.001, respectively). In addition, endoscopic activity scores for intestinal BD were correlated significantly with both CRP levels (γ=0.329) and ESR (γ=0.298), but not with sTREM-1 levels (γ=0.166). CONCLUSION: Unlike CRP levels and ESR, serum sTREM-1 levels were not correlated with endoscopic activity in patients with intestinal BD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent960~966-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBehcet Syndrome/blood*-
dc.subject.MESHBehcet Syndrome/pathology*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHC-Reactive Protein/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIntestinal Diseases/blood*-
dc.subject.MESHIntestinal Diseases/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMembrane Glycoproteins/blood*-
dc.subject.MESHReceptors, Immunologic/blood*-
dc.subject.MESHTriggering Receptor Expressed on Myeloid Cells-1-
dc.titleCorrelation between Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Endoscopic Activity in Intestinal Behçet's Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyun Jung Lee-
dc.contributor.googleauthorHye Sun Shin-
dc.contributor.googleauthorHui Won Jang-
dc.contributor.googleauthorSeung Won Kim-
dc.contributor.googleauthorSoo Jung Park-
dc.contributor.googleauthorSung Pil Hong-
dc.contributor.googleauthorTae Il Kim-
dc.contributor.googleauthorWon Ho Kim-
dc.contributor.googleauthorJae Hee Cheon-
dc.identifier.doi10.3349/ymj.2014.55.4.960-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00774-
dc.contributor.localIdA01079-
dc.contributor.localIdA02182-
dc.contributor.localIdA04404-
dc.contributor.localIdA00656-
dc.contributor.localIdA01539-
dc.contributor.localIdA04030-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24954324-
dc.subject.keywordC-reactive protein-
dc.subject.keywordendoscopic activity-
dc.subject.keyworderythrocyte sedimentation rate-
dc.subject.keywordintestinal Behçet's disease-
dc.subject.keywordtriggering receptor expressed on myeloid cells-1-
dc.contributor.alternativeNameKim, Seung Won-
dc.contributor.alternativeNameKim, Won Ho-
dc.contributor.alternativeNameKim, Tae Il-
dc.contributor.alternativeNamePark, Soo Jung-
dc.contributor.alternativeNameShin, Hye Sun-
dc.contributor.alternativeNameCheon, Jae Hee-
dc.contributor.alternativeNameHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Won Ho-
dc.contributor.affiliatedAuthorKim, Tae Il-
dc.contributor.affiliatedAuthorShin, Hye Sun-
dc.contributor.affiliatedAuthorHong, Sung Pil-
dc.contributor.affiliatedAuthorKim, Seung Won-
dc.contributor.affiliatedAuthorPark, Soo Jung-
dc.contributor.affiliatedAuthorCheon, Jae Hee-
dc.citation.volume55-
dc.citation.number4-
dc.citation.startPage960-
dc.citation.endPage966-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(4) : 960-966, 2014-
dc.identifier.rimsid57207-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers

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