Cited 15 times in
FDG-PET predicts outcomes of treated bone metastasis following palliative radiotherapy in patients with hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 최서희 | - |
dc.date.accessioned | 2015-01-06T17:04:30Z | - |
dc.date.available | 2015-01-06T17:04:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99303 | - |
dc.description.abstract | AIMS: To determine the utility of FDG-PET in predicting long-term infield tumour control after RT in patients with metastatic hepatocellular carcinoma (HCC) to bone. METHODS:Among 223 patients with HCC skeletal metastases diagnosed, we reviewed 22 patients with 45 total sites treated with RT who had at least two FDG-PETs prior to and after RT. The median RT dose was 42 Gy (range, 22-48) with a median fraction of 3 Gy (range, 2-8). Helical tomotherapy was generally offered for lesions that received higher RT dose (36%). The intrahepatic control rate in all patients was 73% at the time of referral. The ratio of tumour SUV to blood-pool activity SUV (SUV-ratio) was calculated. The primary end-points were infield progression-free survival (infield-PFS) and infield event-free survival (infield-EFS; recurrent and intractable pain or skeletal-related events). RESULTS:Among 45 sites, 20 had tumour progression and 21 developed events in the previously treated area. A higher SUV-ratio before RT, SUV-ratio decline and higher radiation dose were independently and significantly correlated with better infield-PFS (both P<0.05). The tumours with a pre-RT SUV-ratio≥3.0 and SUV-ratio decline≥40% had significantly better infield-PFS and EFS than those with either a pre-RT SUV-ratio<3.0 or SUV-ratio decline<40% (both P<0.05). CONCLUSIONS:FDG-PET may help to predict outcomes of infield tumour control following palliative RT for treatment of HCC bone metastases. Tumours with low metabolic uptake before RT or with a minor decline in post-RT SUV-ratio showed poor long-term infield tumour control. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Bone Neoplasms/radiotherapy* | - |
dc.subject.MESH | Bone Neoplasms/secondary* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/radiotherapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18/metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Liver Neoplasms/radiotherapy* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Palliative Care/methods* | - |
dc.subject.MESH | Positron-Emission Tomography/methods | - |
dc.subject.MESH | Radiopharmaceuticals*/metabolism | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | FDG-PET predicts outcomes of treated bone metastasis following palliative radiotherapy in patients with hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Seo Hee Choi | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Yong Hyu Jeong | - |
dc.contributor.googleauthor | Youngin Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.identifier.doi | 10.1111/liv.12487 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A05554 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 24528941 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/liv.12487/abstract | - |
dc.subject.keyword | FDG-PET | - |
dc.subject.keyword | SUV ratio | - |
dc.subject.keyword | bone metastasis | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | radiotherapy | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Jeong, Yong Hyu | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1118 | - |
dc.citation.endPage | 1125 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.34(7) : 1118-1125, 2014 | - |
dc.identifier.rimsid | 55991 | - |
dc.type.rims | ART | - |
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