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FDG-PET predicts outcomes of treated bone metastasis following palliative radiotherapy in patients with hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author성진실-
dc.contributor.author윤미진-
dc.contributor.author장지석-
dc.date.accessioned2015-01-06T17:04:30Z-
dc.date.available2015-01-06T17:04:30Z-
dc.date.issued2014-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99303-
dc.description.abstractAIMS: To determine the utility of FDG-PET in predicting long-term infield tumour control after RT in patients with metastatic hepatocellular carcinoma (HCC) to bone. METHODS:Among 223 patients with HCC skeletal metastases diagnosed, we reviewed 22 patients with 45 total sites treated with RT who had at least two FDG-PETs prior to and after RT. The median RT dose was 42 Gy (range, 22-48) with a median fraction of 3 Gy (range, 2-8). Helical tomotherapy was generally offered for lesions that received higher RT dose (36%). The intrahepatic control rate in all patients was 73% at the time of referral. The ratio of tumour SUV to blood-pool activity SUV (SUV-ratio) was calculated. The primary end-points were infield progression-free survival (infield-PFS) and infield event-free survival (infield-EFS; recurrent and intractable pain or skeletal-related events). RESULTS:Among 45 sites, 20 had tumour progression and 21 developed events in the previously treated area. A higher SUV-ratio before RT, SUV-ratio decline and higher radiation dose were independently and significantly correlated with better infield-PFS (both P<0.05). The tumours with a pre-RT SUV-ratio≥3.0 and SUV-ratio decline≥40% had significantly better infield-PFS and EFS than those with either a pre-RT SUV-ratio<3.0 or SUV-ratio decline<40% (both P<0.05). CONCLUSIONS:FDG-PET may help to predict outcomes of infield tumour control following palliative RT for treatment of HCC bone metastases. Tumours with low metabolic uptake before RT or with a minor decline in post-RT SUV-ratio showed poor long-term infield tumour control.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1118~1125-
dc.relation.isPartOfLIVER INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBone Neoplasms/diagnostic imaging*-
dc.subject.MESHBone Neoplasms/radiotherapy*-
dc.subject.MESHBone Neoplasms/secondary*-
dc.subject.MESHCarcinoma, Hepatocellular/radiotherapy*-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/radiotherapy*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPalliative Care/methods*-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHRadiopharmaceuticals*/metabolism-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHTreatment Outcome-
dc.titleFDG-PET predicts outcomes of treated bone metastasis following palliative radiotherapy in patients with hepatocellular carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorYong Hyu Jeong-
dc.contributor.googleauthorYoungin Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1111/liv.12487-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA05554-
dc.contributor.localIdA01956-
dc.contributor.localIdA02550-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ02171-
dc.identifier.eissn1478-3231-
dc.identifier.pmid24528941-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/liv.12487/abstract-
dc.subject.keywordFDG-PET-
dc.subject.keywordSUV ratio-
dc.subject.keywordbone metastasis-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordradiotherapy-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.affiliatedAuthorJeong, Yong Hyu-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.rights.accessRightsfree-
dc.citation.volume34-
dc.citation.number7-
dc.citation.startPage1118-
dc.citation.endPage1125-
dc.identifier.bibliographicCitationLIVER INTERNATIONAL, Vol.34(7) : 1118-1125, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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