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Cited 18 times in

Cerebral microbleeds in patients with Parkinson's disease.

DC FieldValueLanguage
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.date.accessioned2015-01-06T17:02:57Z-
dc.date.available2015-01-06T17:02:57Z-
dc.date.issued2014-
dc.identifier.issn0340-5354-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99260-
dc.description.abstractCerebral microbleeds (CMBs) are known to be associated with cognitive impairments in the elderly and in patients with various diseases; however, the nature of this association has not yet been evaluated in Parkinson’s disease (PD). In the present study, we analyzed the incidence of CMBs in PD according to cognitive status, and the impact of CMBs on cognitive performance was also evaluated. The CMBs in PD with dementia (n = 36), mild cognitive impairment (MCI, n = 46), or cognitively normal (n = 41) were analyzed using conventional T2*-weighted gradient-recalled echo images. Additionally, the relationship between the presence of CMBs and cognitive performance on individual tests of cognitive subdomains was analyzed using a detailed neuropsychological test. CMBs occurred more frequently in PD patients with dementia (36.1 %) compared to those with MCI (15.2 %), those who are cognitively normal (14.6 %), and normal controls (12.2 %, p = 0.025). However, the significant association of CMBs with PD dementia disappeared after adjusting white matter hyperintensities (WMHs) as a covariate. The frequencies of deep, lobar, and infratentorial CMBs did not differ among the four groups. After adjusting for age, sex, years of education, and WMHs, PD patients with CMBs had poorer performance in attention domain compared with those without CMBs (34.9 vs 42.6, p = 0.018). The present data demonstrate that even though CMBs were inseparably associated with the presence of WMHs, CMBs occur more commonly in PD patients with dementia than in those without dementia. Additionally, the burden of CMBs may contribute to further cognitive impairment in PD.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1628~1635-
dc.relation.isPartOfJournal of Neurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCerebral microbleeds in patients with Parkinson's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorJee Hyun Ham-
dc.contributor.googleauthorHan Yi-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1007/s00415-014-7403-y-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.relation.journalcodeJ01627-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00415-014-7403-y-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.rights.accessRightsfree-
dc.citation.volume261-
dc.citation.number8-
dc.citation.startPage1628-
dc.citation.endPage1635-
dc.identifier.bibliographicCitationJournal of Neurology, Vol.261(8) : 1628-1635, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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