Cited 141 times in
A Randomized, Open-Label, Multicenter Trial for the Safety and Efficacy of Adult Mesenchymal Stem Cells after Acute Myocardial Infarction
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.date.accessioned | 2015-01-06T17:00:37Z | - |
dc.date.available | 2015-01-06T17:00:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99197 | - |
dc.description.abstract | Recent studies suggest that the intracoronary administration of bone marrow (BM)-derived mesenchymal stem cells (MSCs) may improve left ventricular function in patients with acute myocardial infarction (AMI). However, there is still argumentative for the safety and efficacy of MSCs in the AMI setting. We thus performed a randomized pilot study to investigate the safety and efficacy of MSCs in patients with AMI. Eighty patients with AMI after successful reperfusion therapy were randomly assigned and received an intracoronary administration of autologous BM-derived MSCs into the infarct related artery at 1 month. During follow-up period, 58 patients completed the trial. The primary endpoint was changes in left ventricular ejection fraction (LVEF) by single-photon emission computed tomography (SPECT) at 6 month. We also evaluated treatment-related adverse events. The absolute improvement in the LVEF by SPECT at 6 month was greater in the BM-derived MSCs group than in the control group (5.9%±8.5% vs 1.6%±7.0%; P=0.037). There was no treatment-related toxicity during intracoronary administration of MSCs. No significant adverse cardiovascular events occurred during follow-up. In conclusion, the intracoronary infusion of human BM-derived MSCs at 1 month is tolerable and safe with modest improvement in LVEF at 6-month follow-up by SPECT. (ClinicalTrials.gov registration number: NCT01392105) | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 23~31 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Marrow Cells/cytology | - |
dc.subject.MESH | Cell- and Tissue-Based Therapy/adverse effects* | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation/adverse effects* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/cytology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/therapy* | - |
dc.subject.MESH | Pilot Projects | - |
dc.subject.MESH | Stroke Volume | - |
dc.subject.MESH | Tomography, Emission-Computed, Single-Photon | - |
dc.subject.MESH | Transplantation, Autologous | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Ventricular Function, Left | - |
dc.subject.MESH | Young Adult | - |
dc.title | A Randomized, Open-Label, Multicenter Trial for the Safety and Efficacy of Adult Mesenchymal Stem Cells after Acute Myocardial Infarction | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Jun-Won Lee | - |
dc.contributor.googleauthor | Seung-Hwan Lee | - |
dc.contributor.googleauthor | Young-Jin Youn | - |
dc.contributor.googleauthor | Min-Soo Ahn | - |
dc.contributor.googleauthor | Jang-Young Kim | - |
dc.contributor.googleauthor | Byung-Su Yoo | - |
dc.contributor.googleauthor | Junghan Yoon | - |
dc.contributor.googleauthor | Woocheol Kwon | - |
dc.contributor.googleauthor | In-Soo Hong | - |
dc.contributor.googleauthor | Kyounghoon Lee | - |
dc.contributor.googleauthor | Jun Kwan | - |
dc.contributor.googleauthor | Keum Soo Park | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yang Soo Jang | - |
dc.contributor.googleauthor | Mun K. Hong | - |
dc.identifier.doi | 10.3346/jkms.2014.29.1.23 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 24431901 | - |
dc.subject.keyword | Mesenchymal Stem Cells | - |
dc.subject.keyword | Myocardial Infarction | - |
dc.subject.keyword | Ventricular Dysfunction, Left | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 31 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.29(1) : 23-31, 2014 | - |
dc.identifier.rimsid | 51208 | - |
dc.type.rims | ART | - |
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