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Cited 47 times in

Histological subclassification of cirrhosis can predict recurrence after

DC Field Value Language
dc.contributor.author김경식-
dc.contributor.author김도영-
dc.contributor.author김승업-
dc.contributor.author박영년-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author정규식-
dc.contributor.author최기홍-
dc.contributor.author최진섭-
dc.contributor.author한광협-
dc.date.accessioned2015-01-06T16:59:51Z-
dc.date.available2015-01-06T16:59:51Z-
dc.date.issued2014-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99173-
dc.description.abstractBACKGROUND: Recurrence of hepatocellular carcinoma (HCC) after curative resection continues to be a major cause of death. This prospective study is designed to investigate whether histological subclassification of cirrhosis using the Laennec system could predict recurrence in patients with hepatitis B virus (HBV)-related HCC after curative resection. METHODS:Patients with HBV-related HCC who underwent curative resection and showed Laennec stage 3 to 4 were enrolled and the cases with stage 4 were subclassified histologically into three groups (stages 4A, 4B and 4C) according to the Laennec system. Between February 2006 and August 2009, 92 patients were recruited. RESULTS:Stage 3, 4A, 4B and 4C were identified in 24 (26.1%), 15 (16.3%), 43 (46.7%) and 10 (10.9%) patients respectively. The cumulative incidence rates of recurrence at 1, 2 and 3 years were 24.2%, 40.5% and 55.1% respectively. On multivariate analysis, serum albumin [hazard ratio (HR), 0.528; 95% confidence interval (CI), 0.312-0.891; P=0.017] and Edmondson-Steiner grade III-IV (HR, 3.456; 95% CI, 1.123-10.517; P=0.031) were significantly correlated with early recurrence (<1 year), whereas stage 4C (HR, 5.426; 95% CI, 1.030-28.598; P=0.046) was the only independent risk factor for late recurrence (≥1 year). CONCLUSIONS:Histological subclassification of cirrhosis using the Laennec system is a significant predictor of late recurrence in patients with HBV-related HCC after curative resection.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1008~1017-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfLIVER INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHepatectomy/methods-
dc.subject.MESHHepatectomy/statistics & numerical data*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Cirrhosis/classification*-
dc.subject.MESHLiver Cirrhosis/pathology*-
dc.subject.MESHLiver Neoplasms/pathology-
dc.subject.MESHLiver Neoplasms/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/diagnosis*-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegression Analysis-
dc.subject.MESHRisk Factors-
dc.subject.MESHStatistics, Nonparametric-
dc.titleHistological subclassification of cirrhosis can predict recurrence after-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorKyu Sik Jung-
dc.contributor.googleauthorSarah Lee-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorGi Hong Choi-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1111/liv.12475-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00299-
dc.contributor.localIdA00654-
dc.contributor.localIdA01563-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA03578-
dc.contributor.localIdA04046-
dc.contributor.localIdA04199-
dc.contributor.localIdA04268-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02171-
dc.identifier.eissn1478-3231-
dc.identifier.pmid24483989-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/liv.12475/abstract-
dc.subject.keywordchronic hepatitis B-
dc.subject.keywordcirrhosis-
dc.subject.keywordfibrosis-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordlaennec staging-
dc.subject.keywordrecurrence-
dc.subject.keywordresection-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameJung, Kyu Sik-
dc.contributor.alternativeNameChoi, Gi Hong-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorJung, Kyu Sik-
dc.contributor.affiliatedAuthorChoi, Gi Hong-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsfree-
dc.citation.volume34-
dc.citation.number7-
dc.citation.startPage1008-
dc.citation.endPage1017-
dc.identifier.bibliographicCitationLIVER INTERNATIONAL, Vol.34(7) : 1008-1017, 2014-
dc.identifier.rimsid51195-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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