Cited 47 times in
Histological subclassification of cirrhosis can predict recurrence after
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 정규식 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2015-01-06T16:59:51Z | - |
dc.date.available | 2015-01-06T16:59:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/99173 | - |
dc.description.abstract | BACKGROUND: Recurrence of hepatocellular carcinoma (HCC) after curative resection continues to be a major cause of death. This prospective study is designed to investigate whether histological subclassification of cirrhosis using the Laennec system could predict recurrence in patients with hepatitis B virus (HBV)-related HCC after curative resection. METHODS:Patients with HBV-related HCC who underwent curative resection and showed Laennec stage 3 to 4 were enrolled and the cases with stage 4 were subclassified histologically into three groups (stages 4A, 4B and 4C) according to the Laennec system. Between February 2006 and August 2009, 92 patients were recruited. RESULTS:Stage 3, 4A, 4B and 4C were identified in 24 (26.1%), 15 (16.3%), 43 (46.7%) and 10 (10.9%) patients respectively. The cumulative incidence rates of recurrence at 1, 2 and 3 years were 24.2%, 40.5% and 55.1% respectively. On multivariate analysis, serum albumin [hazard ratio (HR), 0.528; 95% confidence interval (CI), 0.312-0.891; P=0.017] and Edmondson-Steiner grade III-IV (HR, 3.456; 95% CI, 1.123-10.517; P=0.031) were significantly correlated with early recurrence (<1 year), whereas stage 4C (HR, 5.426; 95% CI, 1.030-28.598; P=0.046) was the only independent risk factor for late recurrence (≥1 year). CONCLUSIONS:Histological subclassification of cirrhosis using the Laennec system is a significant predictor of late recurrence in patients with HBV-related HCC after curative resection. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1008~1017 | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | LIVER INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/surgery* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatectomy/methods | - |
dc.subject.MESH | Hepatectomy/statistics & numerical data* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Cirrhosis/classification* | - |
dc.subject.MESH | Liver Cirrhosis/pathology* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/diagnosis* | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Regression Analysis | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Statistics, Nonparametric | - |
dc.title | Histological subclassification of cirrhosis can predict recurrence after | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Kyu Sik Jung | - |
dc.contributor.googleauthor | Sarah Lee | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.identifier.doi | 10.1111/liv.12475 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03578 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02171 | - |
dc.identifier.eissn | 1478-3231 | - |
dc.identifier.pmid | 24483989 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/liv.12475/abstract | - |
dc.subject.keyword | chronic hepatitis B | - |
dc.subject.keyword | cirrhosis | - |
dc.subject.keyword | fibrosis | - |
dc.subject.keyword | hepatitis B virus | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | laennec staging | - |
dc.subject.keyword | recurrence | - |
dc.subject.keyword | resection | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Park, Jun Yong | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Jung, Kyu Sik | - |
dc.contributor.alternativeName | Choi, Gi Hong | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Park, Jun Yong | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Jung, Kyu Sik | - |
dc.contributor.affiliatedAuthor | Choi, Gi Hong | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 34 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1008 | - |
dc.citation.endPage | 1017 | - |
dc.identifier.bibliographicCitation | LIVER INTERNATIONAL, Vol.34(7) : 1008-1017, 2014 | - |
dc.identifier.rimsid | 51195 | - |
dc.type.rims | ART | - |
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