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Low-Dose Dexmedetomidine Reduces Emergence Agitation after Desflurane Anaesthesia in Children Undergoing Strabismus Surgery

DC Field Value Language
dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김정민-
dc.contributor.author이재훈-
dc.date.accessioned2015-01-06T16:59:38Z-
dc.date.available2015-01-06T16:59:38Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99166-
dc.description.abstractPURPOSE:Emergence agitation (EA) is frequently observed in children undergoing general anaesthesia. This study tested whether the addition of an intra-operative low-dose infusion of dexmedetomidine to fentanyl treatment reduced the incidence of emergence delirium following desflurane anesthesia in children undergoing strabismus surgery. MATERIALS AND METHODS:A total of 96 children (1-5 years old) undergoing strabismus surgery were enrolled. Anaesthesia was induced with propofol and maintained with desflurane. After induction, fentanyl (1 μg/kg) was administered to all children. During surgery, patients were infused with 0.2 μg/(kg·h)⁻¹ dexmedetomidine (Group FD, n=47) or normal saline (Group F, n=47). Postoperative objective pain score (OPS), Paediatric Agitation and Emergence Delirium (PAED) score, and EA score were documented every 10 minutes in the post-anaesthesia care unit. RESULTS:There were no significant differences between the two groups in demographic characteristics and haemodynamic changes. The mean values of maximum EA, maximum PAED, and maximum OPS score were significantly lower in Group FD than in Group F at 0, 10, and 20 minutes after arrival at the post-anaesthesia care unit (p<0.001). The frequency of fentanyl rescue was lower in Group FD than in Group F (p<0.001). The incidence of severe EA was significantly lower in Group FD than in Group F (12.8% vs. 74.5%, p<0.001). CONCLUSION:Intra-operative low-dose infusion of dexmedetomidine in addition to fentanyl reduces EA following desflurane anaesthesia in children undergoing strabismus surgeries.-
dc.description.statementOfResponsibilityopen-
dc.format.extent508~516-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAkathisia, Drug-Induced/prevention & control*-
dc.subject.MESHAnesthesia Recovery Period-
dc.subject.MESHAnesthesia, General/adverse effects-
dc.subject.MESHAnesthetics, Inhalation/adverse effects*-
dc.subject.MESHAnesthetics, Inhalation/therapeutic use-
dc.subject.MESHChild, Preschool-
dc.subject.MESHDexmedetomidine/administration & dosage*-
dc.subject.MESHDexmedetomidine/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHFentanyl/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHInfant-
dc.subject.MESHIntraoperative Period-
dc.subject.MESHIsoflurane/adverse effects-
dc.subject.MESHIsoflurane/analogs & derivatives*-
dc.subject.MESHIsoflurane/therapeutic use-
dc.subject.MESHMale-
dc.subject.MESHOphthalmologic Surgical Procedures-
dc.subject.MESHPropofol/therapeutic use-
dc.subject.MESHROC Curve-
dc.subject.MESHStrabismus/surgery*-
dc.titleLow-Dose Dexmedetomidine Reduces Emergence Agitation after Desflurane Anaesthesia in Children Undergoing Strabismus Surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology (마취통증의학)-
dc.contributor.googleauthorJeongmin Kim-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorYoung Ran Kang-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.identifier.doi10.3349/ymj.2014.55.2.508-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00193-
dc.contributor.localIdA00884-
dc.contributor.localIdA03092-
dc.contributor.localIdA00616-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24532525-
dc.subject.keywordDexmedetomidine-
dc.subject.keywordemergence agitation-
dc.subject.keywordobjective pain score-
dc.subject.keywordpediatrics-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.alternativeNameKim, So Yeon-
dc.contributor.alternativeNameKim, Jeongmin-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.affiliatedAuthorKu, Bon Nyo-
dc.contributor.affiliatedAuthorKim, Jeongmin-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorKim, So Yeon-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage508-
dc.citation.endPage516-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(2) : 508-516, 2014-
dc.identifier.rimsid51190-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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