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Low Iodine Diet for One Week Is Sufficient for Adequate Preparation of High Dose Radioactive Iodine Ablation Therapy of Differentiated Thyroid Cancer Patients in Iodine-Rich Areas.

DC Field Value Language
dc.contributor.author김법우-
dc.contributor.author박정수-
dc.contributor.author유영훈-
dc.contributor.author이민경-
dc.contributor.author이용상-
dc.contributor.author장항석-
dc.contributor.author전태주-
dc.date.accessioned2015-01-06T16:58:19Z-
dc.date.available2015-01-06T16:58:19Z-
dc.date.issued2014-
dc.identifier.issn1050-7256-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99124-
dc.description.abstractBackground: Most current guidelines suggest one or two weeks of low iodine diet (LID) before radioactive iodine ablation therapy (RAIT) to increase its efficacy in differentiated thyroid cancer (DTC) patients after total thyroidectomy. LID duration is particularly important for patients living in iodine excess areas. However, there is no standardized LID protocol and there are limited reports regarding the relationship between LID and ablation outcome. Therefore, we aimed to evaluate the optimal LID duration and define clinical features that affect ablation outcome. Methods: A total of 202 papillary thyroid cancer patients with total thyroidectomy preparing for RAIT were enrolled. All patients had undergone two weeks of LID before 131I administration. Morning spot urine specimens were obtained twice (one week or two weeks after LID, respectively) from each patient. Urine iodine excretion (UIE) values were used to evaluate LID efficacy. Successful ablation was defined using two definitions: (i) no visible uptake on a follow-up diagnostic 131I scans, and (ii) no visible uptake on a follow-up diagnostic 131I scans and stimulated serum thyroglobulin (Tg) levels <1 ng/mL. Results: The UIE median values after LID for one and two weeks were lower than 50 μg/L, and the median UIE values were not significantly different according to the LID duration. Based on the first criterion for successful ablation, 175 of the 195 patients were successfully ablated. There were no significant differences in mean and median UIE levels between the ablated and non-ablated groups after LID for two weeks. The rate of ablation did not differ between the mild and moderate iodine deficient groups. Based on the second criterion for successful ablation, 149 of 188 patients were successfully ablated. The ablation success rate did not differ between UIE levels. When we analyzed clinical factors that affect ablation outcome, serum Tg level at the time of ablation was the only significant variable in multivariate logistic analysis. Conclusion: Strict LID for one week was sufficient to achieve target UIE values for RAIT preparation, even in iodine-rich areas.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~8-
dc.relation.isPartOfTHYROID-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntibodies/blood-
dc.subject.MESHCell Differentiation-
dc.subject.MESHDiet*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIodine/therapeutic use*-
dc.subject.MESHIodine Radioisotopes/therapeutic use*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPractice Guidelines as Topic-
dc.subject.MESHQuality of Life-
dc.subject.MESHThyroglobulin/blood-
dc.subject.MESHThyroglobulin/immunology-
dc.subject.MESHThyroid Neoplasms/radiotherapy*-
dc.subject.MESHThyroidectomy/methods-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleLow Iodine Diet for One Week Is Sufficient for Adequate Preparation of High Dose Radioactive Iodine Ablation Therapy of Differentiated Thyroid Cancer Patients in Iodine-Rich Areas.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학)-
dc.contributor.googleauthorLee Minkyung-
dc.contributor.googleauthorLee Yu Kyung-
dc.contributor.googleauthorJeon Tae Joo-
dc.contributor.googleauthorChang Hang Seok-
dc.contributor.googleauthorKim Bup-Woo-
dc.contributor.googleauthorLee Yong Sang-
dc.contributor.googleauthorPark Cheong Soo-
dc.contributor.googleauthorRyu Young Hoon-
dc.identifier.doi10.1089/thy.2013.0695-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03557-
dc.contributor.localIdA00491-
dc.contributor.localIdA02485-
dc.contributor.localIdA02780-
dc.contributor.localIdA02978-
dc.contributor.localIdA03488-
dc.contributor.localIdA01646-
dc.relation.journalcodeJ02729-
dc.identifier.eissn1557-9077-
dc.identifier.pmid24731156-
dc.identifier.urlhttp://online.liebertpub.com/doi/abs/10.1089/thy.2013.0695-
dc.contributor.alternativeNameKim, Bup Woo-
dc.contributor.alternativeNamePark, Cheong Soo-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Min Kyung-
dc.contributor.alternativeNameLee, Yong Sang-
dc.contributor.alternativeNameChang, Hang Seok-
dc.contributor.alternativeNameJeon, Tae Joo-
dc.contributor.affiliatedAuthorJeon, Tae Joo-
dc.contributor.affiliatedAuthorKim, Bup Woo-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Min Kyung-
dc.contributor.affiliatedAuthorLee, Yong Sang-
dc.contributor.affiliatedAuthorChang, Hang Seok-
dc.contributor.affiliatedAuthorPark, Cheong Soo-
dc.rights.accessRightsfree-
dc.citation.volume24-
dc.citation.number8-
dc.citation.startPage1-
dc.citation.endPage8-
dc.identifier.bibliographicCitationTHYROID, Vol.24(8) : 1-8, 2014-
dc.identifier.rimsid50276-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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