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Predicting Recurrence of Pancreatic Solid Pseudopapillary Tumors After Surgical Resection: A Multicenter Analysis in Korea

DC Field Value Language
dc.contributor.author강창무-
dc.contributor.author이우정-
dc.contributor.author최성훈-
dc.date.accessioned2015-01-06T16:56:59Z-
dc.date.available2015-01-06T16:56:59Z-
dc.date.issued2014-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99081-
dc.description.abstractBACKGROUND: Solid pseudopapillary tumors (SPTs) of the pancreas are still considered a surgical enigma. Many clinical research trials have failed to identify prognostic factors that predict the malignant behavior of SPTs. MATERIALS AND METHODS: This work was a retrospective multicenter study that included a total of 17 medical institutions. Data from 351 patients who underwent surgical resection from January 1990 to December 2008 were retrospectively collected using standardized case report forms requesting clinicopathologic features. RESULTS: Thirty-four patients (9.7%) were male, and 317 (90.3%) were female, with a mean age of 36.8 ± 12.4 years. Recently, minimally invasive (P < 0.001) and parenchyma or function-preserving limited surgeries (P = 0.016) have been more frequently applied for the treatment of pancreatic SPTs. Ninety-eight patients (27.9%) had microscopic malignant features. Only 9 patients (2.6%) experienced tumor recurrence after the initial pancreatic SPT resection. Multivariate analysis showed that a tumor size larger than 8 cm [Exp (β) = 7.385, P = 0.018], microscopic malignant features [Exp (β) = 10.009, P = 0.011], and stage IV [Exp (β) = 42.003, P = 0.002] were significant prognostic factors for tumor recurrence. When combined with stage IV, the microscopic malignant features and 2010 World Health Organization definition of solid pseudopapillary carcinoma more successfully differentiated future recurrence risk groups (P < 0.001). CONCLUSIONS: More specific pathologic descriptions need to be employed in pathologic report forms to provide proper information to predict SPT recurrence after resection. Future studies emphasizing the standardized pathologic evaluation of pancreatic SPTs may unveil the enigmatic nature of pancreatic SPTs.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoma, Papillary/pathology*-
dc.subject.MESHCarcinoma, Papillary/surgery*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHNeoplasm Recurrence, Local-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPancreatectomy-
dc.subject.MESHPancreatic Neoplasms/pathology*-
dc.subject.MESHPancreatic Neoplasms/surgery*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.titlePredicting Recurrence of Pancreatic Solid Pseudopapillary Tumors After Surgical Resection: A Multicenter Analysis in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorSung Hoon Choi-
dc.contributor.googleauthorSong Cheol Kim-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorDong Wook Choi-
dc.contributor.googleauthorSun Whe Kim-
dc.identifier.doi10.1097/SLA.0000000000000583-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04085-
dc.contributor.localIdA02993-
dc.contributor.localIdA00088-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid24743622-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000658-201408000-00024&LSLINK=80&D=ovft-
dc.subject.keywordmalignant-
dc.subject.keywordpancreas-
dc.subject.keywordrecurrence-
dc.subject.keywordsolid pseudopapillary tumor-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameChoi, Sung Hoon-
dc.contributor.affiliatedAuthorChoi, Sung Hoon-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.rights.accessRightsfree-
dc.citation.volume260-
dc.citation.number2-
dc.citation.startPage348-
dc.citation.endPage355-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.260(2) : 348-355, 2014-
dc.identifier.rimsid50250-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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