Cited 12 times in

Diverse geometric changes related to dynamic left ventricular outflow tract obstruction without overt hypertrophic cardiomyopathy

DC Field Value Language
dc.contributor.author권혁문-
dc.contributor.author김종윤-
dc.contributor.author민필기-
dc.contributor.author윤영원-
dc.contributor.author윤지현-
dc.contributor.author이병권-
dc.contributor.author임세중-
dc.contributor.author정혜문-
dc.contributor.author최의영-
dc.contributor.author홍범기-
dc.contributor.author차정준-
dc.date.accessioned2015-01-06T16:56:55Z-
dc.date.available2015-01-06T16:56:55Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/99079-
dc.description.abstractBACKGROUND: Dynamic left ventricular (LV) outflow tract (LVOT) obstruction (DLVOTO) is not infrequently observed in older individuals without overt hypertrophic cardiomyopathy (HCM). We sought to investigate associated geometric changes and then evaluate their clinical characteristics. METHODS: A total of 168 patients with DLVOTO, which was defined as a trans-LVOT peak pressure gradient (PG) higher than 30 mmHg at rest or provoked by Valsalva maneuver (latent LVOTO) without fixed stenosis, were studied. Patients with classical HCM, acute myocardial infarction, stress induced cardiomyopathy or unstable hemodynamics which potentially induce transient-DLVOTO were excluded. RESULTS: Their mean age was 71 ± 11 years and 98 (58%) patients were women. Patients were classified as pure sigmoid septum (n = 14) if they have basal septal bulging but diastolic thickness less than 15 mm, sigmoid septum with basal septal hypertrophy for a thickness ≥15 mm (n = 85), prominent papillary muscle (PM) (n = 20) defined by visually large PMs which occluded the LV cavity during systole or 1/2 LVESD, or as having a small LV cavity with concentric remodelling or hypertrophy (n = 49). The prominent PM group was younger, had a higher S' and lower E/e' than other groups. In all groups, a higher peak trans-LVOT PG was related (p < 0.10) to higher E/e', systolic blood pressure, relative wall thickness, and pulmonary arterial systolic pressure. In multivariate analysis, resting trans-LVOT PG correlated to pulmonary arterial pressure (ß = 0.226, p = 0.019) after adjustment for systolic blood pressure, relative wall thickness, and E/e'. CONCLUSIONS: DLVOTO develops from various reasons, and patients with prominent PMs have distinct characteristics. We suggest to use DLVOTO-relieving medication might reduce pulmonary pressure in this group of patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~8-
dc.relation.isPartOfCARDIOVASCULAR ULTRASOUND-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAging-
dc.subject.MESHCardiomyopathy, Hypertrophic/diagnostic imaging*-
dc.subject.MESHCardiomyopathy, Hypertrophic/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHHeart Septum/diagnostic imaging-
dc.subject.MESHHeart Septum/physiology-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPapillary Muscles/diagnostic imaging*-
dc.subject.MESHPapillary Muscles/physiopathology-
dc.subject.MESHPulmonary Wedge Pressure/physiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSystole/physiology-
dc.subject.MESHUltrasonography-
dc.subject.MESHValsalva Maneuver/physiology-
dc.subject.MESHVentricular Dysfunction, Left/diagnostic imaging*-
dc.subject.MESHVentricular Dysfunction, Left/physiopathology-
dc.subject.MESHVentricular Outflow Obstruction/diagnostic imaging*-
dc.subject.MESHVentricular Outflow Obstruction/physiopathology-
dc.subject.MESHVentricular Pressure/physiology-
dc.titleDiverse geometric changes related to dynamic left ventricular outflow tract obstruction without overt hypertrophic cardiomyopathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung-Joon Cha-
dc.contributor.googleauthorHyemoon Chung-
dc.contributor.googleauthorYoung Won Yoon-
dc.contributor.googleauthorJi Hyun Yoon-
dc.contributor.googleauthorJong-Youn Kim-
dc.contributor.googleauthorPil-Ki Min-
dc.contributor.googleauthorByoung-Kwon Lee-
dc.contributor.googleauthorBum-Kee Hong-
dc.contributor.googleauthorSe-Joong Rim-
dc.contributor.googleauthorHyuck Moon Kwon-
dc.contributor.googleauthorEui-Young Choi-
dc.identifier.doi10.1186/1476-7120-12-23-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00260-
dc.contributor.localIdA00926-
dc.contributor.localIdA01412-
dc.contributor.localIdA02580-
dc.contributor.localIdA02609-
dc.contributor.localIdA02793-
dc.contributor.localIdA03372-
dc.contributor.localIdA03779-
dc.contributor.localIdA04165-
dc.contributor.localIdA04394-
dc.contributor.localIdA04851-
dc.relation.journalcodeJ00466-
dc.identifier.eissn1476-7120-
dc.identifier.pmid24993692-
dc.subject.keywordDynamic left ventricular outflow tract obstruction-
dc.subject.keywordSigmoid septum-
dc.subject.keywordAging-
dc.contributor.alternativeNameKwon, Hyuck Moon-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNameMin, Pil Ki-
dc.contributor.alternativeNameYoon, Young Won-
dc.contributor.alternativeNameYoon, Ji Hyun-
dc.contributor.alternativeNameLee, Byoung Kwon-
dc.contributor.alternativeNameRim, Se Joong-
dc.contributor.alternativeNameChung, Hye Moon-
dc.contributor.alternativeNameChoi, Eui Young-
dc.contributor.alternativeNameHong, Bum Kee-
dc.contributor.affiliatedAuthorKwon, Hyuck Moon-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorMin, Pil Ki-
dc.contributor.affiliatedAuthorYoon, Young Won-
dc.contributor.affiliatedAuthorYoon, Ji Hyun-
dc.contributor.affiliatedAuthorLee, Byoung Kwon-
dc.contributor.affiliatedAuthorRim, Se Joong-
dc.contributor.affiliatedAuthorChung, Hye Moon-
dc.contributor.affiliatedAuthorChoi, Eui Young-
dc.contributor.affiliatedAuthorHong, Bum Kee-
dc.contributor.affiliatedAuthorCha, Jung Joon-
dc.citation.volume12-
dc.citation.number23-
dc.citation.startPage1-
dc.citation.endPage8-
dc.identifier.bibliographicCitationCARDIOVASCULAR ULTRASOUND, Vol.12(23) : 1-8, 2014-
dc.identifier.rimsid50248-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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