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Downregulation of glutathione peroxidase 3 is associated with lymph node metastasis and prognosis in cervical cancer

 Xianglan Zhang  ;  Zhenlong Zheng  ;  Shen Yingji  ;  Hyeyeon Kim  ;  Renshun Jin  ;  Li Renshu  ;  Doo Young Lee  ;  Mi Ryung Roh  ;  Sanghwa Yang 
 ONCOLOGY REPORTS, Vol.31(6) : 2587-2592, 2014 
Journal Title
Issue Date
Azacitidine/administration & dosage ; Azacitidine/analogs & derivatives ; CpG Islands/drug effects ; DNA Methylation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Glutathione Peroxidase/biosynthesis* ; Glutathione Peroxidase/genetics ; HeLa Cells ; Humans ; Lymphatic Metastasis/genetics* ; Lymphatic Metastasis/pathology ; Prognosis* ; Promoter Regions, Genetic/drug effects ; Uterine Cervical Neoplasms/genetics* ; Uterine Cervical Neoplasms/pathology
cervical cancer ; GPX3 ; downregulation ; lymph node metastasis ; prognosis
Glutathione peroxidase 3 (GPX3) is a member of the glutathione peroxidase family of selenoproteins and is one of the key defensive enzymes against oxidative damages to host cells. Downregulation of GPX3 due to its promoter hypermethylation has been documented in several different types of cancer, indicating that GPX3 functions as a possible tumor suppressor. In the present study, we showed that GPX3 is also significantly downregulated in cervical cancer tissues compared to normal cervical tissues by qRT-PCR analyses and immunohistostainings. GPX3 expression was significantly related to lymph node metastasis and prognosis in cervical cancer patients. Treatment of cervical cancer cells with 5-aza-2'-deoxycytidine restored the expression of GPX3 and methylation-specific PCR (MSP) confirmed the CpG methylation of the GPX3 gene. Our results indicate that promoter methylation is one of the major causes of GPX3 downregulation in cervical cancer and GPX3 could serve as a predictive biomarker for lymph node metastasis and prognosis of cervical cancer.
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5. Research Institutes (연구소) > Cancer Metastasis Research Center (암전이연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Kim, Hye Yeon(김혜연)
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Yang, Sang Hwa(양상화)
Lee, Doo Young(이두영)
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