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Prognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis

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dc.contributor.author박준용-
dc.contributor.author신혜선-
dc.contributor.author안상훈-
dc.contributor.author전재윤-
dc.contributor.author한광협-
dc.contributor.author한상훈-
dc.contributor.author김도영-
dc.contributor.author김샛별-
dc.date.accessioned2015-01-06T16:53:20Z-
dc.date.available2015-01-06T16:53:20Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98963-
dc.description.abstractPURPOSE: Due to the seroepidemiological shift in hepatitis A (HA), its severity, mortality, and complications have increased in recent years. Thus, the aim of this study was to identify predictive factors associated with poor prognosis among patients with HA. MATERIALS AND METHODS: A total of 304 patients with HA admitted to our institution between July 2009 and June 2011 were enrolled consecutively. Patients with complications defined as acute liver failure (ALF) were evaluated, and mortality was defined as death or liver transplantation. RESULTS: The mean age of patients (204 males, 100 females) was 32 years. Eighteen (5.9%) patients had progressed to ALF. Of the patients with ALF, 10 patients (3.3%) showed spontaneous survival while 8 (2.6%) died or underwent liver transplantation. Multivariate regression analysis showed that Model for End-Stage Liver Disease (MELD) and systemic inflammatory response syndrome (SIRS) scores were significant predictive factors of ALF. Based on receiver operating characteristics (ROC) analysis, a MELD≥23.5 was significantly more predictive than a SIRS score≥3 (area under the ROC: 0.940 vs. 0.742, respectively). In addition, of patients with a MELD score≥23.5, King's College Hospital criteria (KCC) and SIRS scores were predictive factors associated with death/transplantation in multivariate analysis. CONCLUSION: MELD and SIRS scores≥23.5 and ≥3, respectively, appeared to be related to ALF development. In addition, KCC and SIRS scores≥3 were valuable in predicting mortality of patients with a MELD≥23.5.-
dc.description.statementOfResponsibilityopen-
dc.format.extent953~959-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHHepatitis A/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Failure, Acute/etiology*-
dc.subject.MESHLiver Failure, Acute/mortality*-
dc.subject.MESHLiver Failure, Acute/pathology-
dc.subject.MESHMale-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHSystemic Inflammatory Response Syndrome/complications-
dc.titlePrognostic Indicators for Acute Liver Failure Development and Mortality in Patients with Hepatitis A: Consecutive Case Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHye Sun Shin-
dc.contributor.googleauthorSae Pyul Kim-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorChae Yoon Chon-
dc.contributor.googleauthorJun Yong Park-
dc.identifier.doi10.3349/ymj.2014.55.4.953-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01675-
dc.contributor.localIdA02182-
dc.contributor.localIdA02226-
dc.contributor.localIdA04268-
dc.contributor.localIdA04286-
dc.contributor.localIdA00538-
dc.contributor.localIdA03544-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24954323-
dc.subject.keywordAcute liver failure-
dc.subject.keywordhepatitis A-
dc.subject.keywordmortality-
dc.subject.keywordprognostic indicator-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameShin, Hye Sun-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameChon, Chae Yoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Sae Byol-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorShin, Hye Sun-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, Sae Byol-
dc.contributor.affiliatedAuthorChon, Chae Yoon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume55-
dc.citation.number4-
dc.citation.startPage953-
dc.citation.endPage959-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(4) : 953-959, 2014-
dc.identifier.rimsid54313-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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