Cited 33 times in
New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2015-01-06T16:52:38Z | - |
dc.date.available | 2015-01-06T16:52:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98941 | - |
dc.description.abstract | Previous studies have revealed the association between SNPs located on human leukocyte antigen (HLA) class II genes, including HLA-DP and HLA-DQ, and chronic hepatitis B virus (HBV) infection, mainly in Asian populations. HLA-DP alleles or haplotypes associated with chronic HBV infection or disease progression have not been fully identified in Asian populations. We performed trans-ethnic association analyses of HLA-DPA1, HLA-DPB1 alleles and haplotypes with hepatitis B virus infection and disease progression among Asian populations comprising Japanese, Korean, Hong Kong, and Thai subjects. To assess the association between HLA-DP and chronic HBV infection and disease progression, we conducted high-resolution (4-digit) HLA-DPA1 and HLA-DPB1 genotyping in a total of 3,167 samples, including HBV patients, HBV-resolved individuals and healthy controls. Trans-ethnic association analyses among Asian populations identified a new risk allele HLA-DPB1*09:01 (P = 1.36×10−6; OR = 1.97; 95% CI, 1.50–2.59) and a new protective allele DPB1*02:01 (P = 5.22×10−6; OR = 0.68; 95% CI, 0.58–0.81) to chronic HBV infection, in addition to the previously reported alleles. Moreover, DPB1*02:01 was also associated with a decreased risk of disease progression in chronic HBV patients among Asian populations (P = 1.55×10−7; OR = 0.50; 95% CI, 0.39–0.65). Trans-ethnic association analyses identified Asian-specific associations of HLA-DP alleles and haplotypes with HBV infection or disease progression. The present findings will serve as a base for future functional studies of HLA-DP molecules in order to understand the pathogenesis of HBV infection and the development of hepatocellular carcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e86449 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Alleles* | - |
dc.subject.MESH | Asia | - |
dc.subject.MESH | Disease Resistance/genetics* | - |
dc.subject.MESH | Disease Resistance/immunology | - |
dc.subject.MESH | Ethnic Groups/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Association Studies* | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | HLA-DP Antigens/genetics | - |
dc.subject.MESH | Haplotypes/genetics | - |
dc.subject.MESH | Hepatitis B/genetics* | - |
dc.subject.MESH | Hepatitis B/immunology | - |
dc.subject.MESH | Hepatitis B virus/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Young Adult | - |
dc.title | New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Nao Nishida | - |
dc.contributor.googleauthor | Hiromi Sawai | - |
dc.contributor.googleauthor | Koichi Kashiwase | - |
dc.contributor.googleauthor | Mutsuhiko Minami | - |
dc.contributor.googleauthor | Masaya Sugiyama | - |
dc.contributor.googleauthor | Wai-Kay Seto | - |
dc.contributor.googleauthor | Man-Fung Yuen | - |
dc.contributor.googleauthor | Nawarat Posuwan | - |
dc.contributor.googleauthor | Yong Poovorawan | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Kentaro Matsuura | - |
dc.contributor.googleauthor | Yasuhito Tanaka | - |
dc.contributor.googleauthor | Masayuki Kurosaki | - |
dc.contributor.googleauthor | Yasuhiro Asahina | - |
dc.contributor.googleauthor | Namiki Izumi | - |
dc.contributor.googleauthor | Jong-Hon Kang | - |
dc.contributor.googleauthor | Shuhei Hige | - |
dc.contributor.googleauthor | Tatsuya Ide | - |
dc.contributor.googleauthor | Kazuhide Yamamoto | - |
dc.contributor.googleauthor | Isao Sakaida | - |
dc.contributor.googleauthor | Yoshikazu Murawaki | - |
dc.contributor.googleauthor | Yoshito Itoh | - |
dc.contributor.googleauthor | Akihiro Tamori | - |
dc.contributor.googleauthor | Etsuro Orito | - |
dc.contributor.googleauthor | Yoichi Hiasa | - |
dc.contributor.googleauthor | Masao Honda | - |
dc.contributor.googleauthor | Shuichi Kaneko | - |
dc.contributor.googleauthor | Eiji Mita | - |
dc.contributor.googleauthor | Kazuyuki Suzuki | - |
dc.contributor.googleauthor | Keisuke Hino | - |
dc.contributor.googleauthor | Eiji Tanaka | - |
dc.contributor.googleauthor | Satoshi Mochida | - |
dc.contributor.googleauthor | Masaaki Watanabe | - |
dc.contributor.googleauthor | Yuichiro Eguchi | - |
dc.contributor.googleauthor | Naohiko Masaki | - |
dc.contributor.googleauthor | Kazumoto Murata | - |
dc.contributor.googleauthor | Masaaki Korenaga | - |
dc.contributor.googleauthor | Yoriko Mawatari | - |
dc.contributor.googleauthor | Jun Ohashi | - |
dc.contributor.googleauthor | Minae Kawashima | - |
dc.contributor.googleauthor | Katsushi Tokunaga | - |
dc.contributor.googleauthor | Masashi Mizokami | - |
dc.identifier.doi | 10.1371/journal.pone.0086449 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24520320 | - |
dc.contributor.alternativeName | Ahn, Sang Hoon | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Ahn, Sang Hoon | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e86449 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(2) : e86449, 2014 | - |
dc.identifier.rimsid | 54295 | - |
dc.type.rims | ART | - |
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