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Cited 3 times in

Clinical Factors Associated with Acquisition of Resistance to Levofloxacin in Stenotrophomonas maltophilia

DC FieldValueLanguage
dc.contributor.author구남수-
dc.contributor.author김준명-
dc.contributor.author김창오-
dc.contributor.author백지현-
dc.contributor.author송영구-
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2015-01-06T16:52:17Z-
dc.date.available2015-01-06T16:52:17Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98930-
dc.description.abstractPURPOSE: Fluoroquinolones, rapidly gaining prominence in treatment of Stenotrophomonas maltophilia (SMP), are noted for their potency and tolerability. However, SMP may rapidly acquire resistance to fluoroquinolones. We evaluated associations of clinical factors with acquisition of levofloxacin resistance (LFr) in SMP. MATERIALS AND METHODS: Our retrospective cohort study was based on patient data collected between January 2008 and June 2010. Through screening of 1275 patients, we identified 122 patients with data for SMP antibiotic susceptibility testing in ≥3 serial SMP isolates. RESULTS: We assigned the 122 patients to either the SS group (n=54) in which levofloxacin susceptibility was maintained or the SR group (n=31) in which susceptible SMP acquired resistance. In multivariate regression analysis, exposure to levofloxacin for more than 3 weeks [odds ratio (OR) 15.39, 95% confidential interval (CI) 3.08-76.93, p=0.001] and co-infection or co-colonization with Klebsiella pneumoniae resistant to levofloxacin (OR 4.85, 95% CI 1.16-20.24, p=0.030) were independently associated with LFr acquisition in SMP. CONCLUSION: Acquisition of LFr during serial sampling of SMP was related to the levofloxacin exposure.-
dc.description.statementOfResponsibilityopen-
dc.format.extent987~993-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/pharmacology*-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHFluoroquinolones/pharmacology-
dc.subject.MESHFluoroquinolones/therapeutic use-
dc.subject.MESHGram-Negative Bacterial Infections/drug therapy-
dc.subject.MESHHumans-
dc.subject.MESHLevofloxacin/pharmacology*-
dc.subject.MESHLevofloxacin/therapeutic use*-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStenotrophomonas maltophilia/drug effects-
dc.subject.MESHStenotrophomonas maltophilia/pathogenicity*-
dc.titleClinical Factors Associated with Acquisition of Resistance to Levofloxacin in Stenotrophomonas maltophilia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJi Hyeon Baek-
dc.contributor.googleauthorChang Oh Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Soo Ku-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.3349/ymj.2014.55.4.987-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00189-
dc.contributor.localIdA00953-
dc.contributor.localIdA01044-
dc.contributor.localIdA01839-
dc.contributor.localIdA02037-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24954328-
dc.subject.keywordStenotrophomonas maltophilia-
dc.subject.keyworddrug resistance-
dc.subject.keywordfluoroquinolones-
dc.subject.keywordlevofloxacin-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Chang Oh-
dc.contributor.alternativeNameBaek, Ji Hyeon-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Chang Oh-
dc.contributor.affiliatedAuthorBaek, Ji Hyeon-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume55-
dc.citation.number4-
dc.citation.startPage987-
dc.citation.endPage993-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(4) : 987-993, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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