Cited 4 times in
Unrecognized kinetics of serum testosterone: Impact on short-term androgen deprivation therapy for prostate cancer
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 이동훈 | - |
dc.contributor.author | 이승환 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.contributor.author | 홍창희 | - |
dc.date.accessioned | 2015-01-06T16:51:48Z | - |
dc.date.available | 2015-01-06T16:51:48Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98914 | - |
dc.description.abstract | PURPOSE: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. MATERIALS AND METHODS: This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexual aberrance. Thirty-three and 25 patients who received 3 and 6 months of ADT were assigned to Group A and Group B, respectively. Serum T levels were obtained every week during the on-cycle period, then monthly during the off-cycle period for at least 12 months. RESULTS: The kinetics of serum T during the on-cycle period were similar in both groups. After flare reaction at week 2, a nadir of 0.45±0.29 ng/mL was achieved. In Group A, an abrupt rebound-upsurge was observed during the first 2 month off-cycle period, which surpassed the baseline level and reached a plateau level of 8.74±2.11 ng/mL during the flare (p<0.001). This upsurge was followed by a gradual decline back to baseline over the following 10 months. In Group B, a gradual increase was observed, and a baseline level of 7.26±1.73 ng/mL was reached at 5 months. Thereafter, an ongoing upsurge that surpassed baseline levels was observed until 12 months (8.81±1.92 ng/mL; p=0.002). CONCLUSION: The kinetics of serum T recovery during the off-cycle period varied according to the duration of ADT. Serum T should be monitored beyond normalization, as an excessive rebound may improve quality-of-life, but hamper the treatment efficacy of PCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 570~575 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Androgen Antagonists/therapeutic use* | - |
dc.subject.MESH | Follicle Stimulating Hormone/blood | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Luteinizing Hormone/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Prostatic Neoplasms/blood* | - |
dc.subject.MESH | Prostatic Neoplasms/drug therapy* | - |
dc.subject.MESH | Testosterone/blood* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Unrecognized kinetics of serum testosterone: Impact on short-term androgen deprivation therapy for prostate cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Dong Hoon Lee | - |
dc.contributor.googleauthor | Kyu Hyun Kim | - |
dc.contributor.googleauthor | Seung Hwan Lee | - |
dc.contributor.googleauthor | Chang Hee Hong | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.identifier.doi | 10.3349/ymj.2014.55.3.570 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02742 | - |
dc.contributor.localId | A02938 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04402 | - |
dc.contributor.localId | A04447 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 24719121 | - |
dc.subject.keyword | Androgens | - |
dc.subject.keyword | kinetics | - |
dc.subject.keyword | testosterone | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Lee, Dong Hoon | - |
dc.contributor.alternativeName | Lee, Seung Hwan | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.alternativeName | Hong, Chang Hee | - |
dc.contributor.affiliatedAuthor | Lee, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Seung Hwan | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Hong, Chang Hee | - |
dc.citation.volume | 55 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 570 | - |
dc.citation.endPage | 575 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(3) : 570-575, 2014 | - |
dc.identifier.rimsid | 53777 | - |
dc.type.rims | ART | - |
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