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Unrecognized kinetics of serum testosterone: Impact on short-term androgen deprivation therapy for prostate cancer

DC Field Value Language
dc.contributor.author구교철-
dc.contributor.author이동훈-
dc.contributor.author이승환-
dc.contributor.author정병하-
dc.contributor.author홍성준-
dc.contributor.author홍창희-
dc.date.accessioned2015-01-06T16:51:48Z-
dc.date.available2015-01-06T16:51:48Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98914-
dc.description.abstractPURPOSE: To evaluate the kinetics of serum testosterone (T) recovery following short-term androgen deprivation therapy (ADT), as the understanding thereof is essential for the proper management of prostate cancer (PCa), especially intermittent ADT. MATERIALS AND METHODS: This prospective analysis included male sex offenders who voluntarily received leuprolide acetate in order to alleviate sexual aberrance. Thirty-three and 25 patients who received 3 and 6 months of ADT were assigned to Group A and Group B, respectively. Serum T levels were obtained every week during the on-cycle period, then monthly during the off-cycle period for at least 12 months. RESULTS: The kinetics of serum T during the on-cycle period were similar in both groups. After flare reaction at week 2, a nadir of 0.45±0.29 ng/mL was achieved. In Group A, an abrupt rebound-upsurge was observed during the first 2 month off-cycle period, which surpassed the baseline level and reached a plateau level of 8.74±2.11 ng/mL during the flare (p<0.001). This upsurge was followed by a gradual decline back to baseline over the following 10 months. In Group B, a gradual increase was observed, and a baseline level of 7.26±1.73 ng/mL was reached at 5 months. Thereafter, an ongoing upsurge that surpassed baseline levels was observed until 12 months (8.81±1.92 ng/mL; p=0.002). CONCLUSION: The kinetics of serum T recovery during the off-cycle period varied according to the duration of ADT. Serum T should be monitored beyond normalization, as an excessive rebound may improve quality-of-life, but hamper the treatment efficacy of PCa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent570~575-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAndrogen Antagonists/therapeutic use*-
dc.subject.MESHFollicle Stimulating Hormone/blood-
dc.subject.MESHHumans-
dc.subject.MESHLuteinizing Hormone/blood-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHProstatic Neoplasms/blood*-
dc.subject.MESHProstatic Neoplasms/drug therapy*-
dc.subject.MESHTestosterone/blood*-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.titleUnrecognized kinetics of serum testosterone: Impact on short-term androgen deprivation therapy for prostate cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorDong Hoon Lee-
dc.contributor.googleauthorKyu Hyun Kim-
dc.contributor.googleauthorSeung Hwan Lee-
dc.contributor.googleauthorChang Hee Hong-
dc.contributor.googleauthorSung Joon Hong-
dc.contributor.googleauthorByung Ha Chung-
dc.identifier.doi10.3349/ymj.2014.55.3.570-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02742-
dc.contributor.localIdA02938-
dc.contributor.localIdA00188-
dc.contributor.localIdA03607-
dc.contributor.localIdA04402-
dc.contributor.localIdA04447-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24719121-
dc.subject.keywordAndrogens-
dc.subject.keywordkinetics-
dc.subject.keywordtestosterone-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.alternativeNameLee, Dong Hoon-
dc.contributor.alternativeNameLee, Seung Hwan-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.alternativeNameHong, Chang Hee-
dc.contributor.affiliatedAuthorLee, Dong Hoon-
dc.contributor.affiliatedAuthorLee, Seung Hwan-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.contributor.affiliatedAuthorHong, Chang Hee-
dc.citation.volume55-
dc.citation.number3-
dc.citation.startPage570-
dc.citation.endPage575-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(3) : 570-575, 2014-
dc.identifier.rimsid53777-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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