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Factors Affecting the Accuracy of Controlled Attenuation Parameter (CAP) in Assessing Hepatic Steatosis in Patients with Chronic Liver Disease

DC Field Value Language
dc.contributor.author전경현-
dc.contributor.author정규식-
dc.contributor.author한광협-
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김성배-
dc.contributor.author김승업-
dc.contributor.author박영년-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author안성수-
dc.contributor.author이상훈-
dc.date.accessioned2015-01-06T16:50:55Z-
dc.date.available2015-01-06T16:50:55Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98886-
dc.description.abstractBACKGROUND & AIMS: Controlled attenuation parameter (CAP) can measure hepatic steatosis. However, factors affecting its accuracy have not been described yet. This study investigated predictors of discordance between liver biopsy (LB) and CAP. METHODS: A total of 161 consecutive patients with chronic liver disease who underwent LB and CAP were enrolled prospectively. Histological steatosis was graded as S0 (<5%), S1 (5-33%), S2 (34-66%), and S3 (>66% of hepatocytes). Cutoff CAP values were calculated from our cohort (250, 301, and 325 dB/m for ≥ S1, ≥ S2, and S3). Discordance was defined as a discrepancy of at least two steatosis stages between LB and CAP. RESULTS: The median age (102 males and 59 females) was 49 years. Repartition of histological steatosis was as follows; S0 26.1% (n = 42), S1 49.7% (n = 80), S2 20.5% (n = 33), and S3 3.7% (n = 6). In multivariate linear regression analysis, CAP value was independently associated with steatosis grade along with body mass index (BMI) and interquartile range/median of CAP value (IQR/MCAP) (all P<0.05). Discordance was identified in 13 (8.1%) patients. In multivariate analysis, histological S3 (odd ratio [OR], 9.573; 95% confidence interval [CI], 1.207-75.931; P = 0.033) and CAP value (OR, 1.020; 95% CI, 1.006-1.034; P = 0.006) were significantly associated with discordance, when adjusting for BMI, IQR/MCAP, and necroinflammation, reflected by histological activity or ALT level. CONCLUSIONS: Patients with high grade steatosis or high CAP values have a higher risk of discordance between LB and CAP. Further studies are needed to improve the accuracy of CAP interpretation, especially in patients with higher CAP values.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiopsy-
dc.subject.MESHBlood Chemical Analysis-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHFatty Liver/complications-
dc.subject.MESHFatty Liver/diagnosis*-
dc.subject.MESHFatty Liver/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver Diseases/complications-
dc.subject.MESHLiver Diseases/diagnosis*-
dc.subject.MESHLiver Diseases/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHYoung Adult-
dc.titleFactors Affecting the Accuracy of Controlled Attenuation Parameter (CAP) in Assessing Hepatic Steatosis in Patients with Chronic Liver Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorKyu Sik Jung-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorYoung Eun Chon-
dc.contributor.googleauthorKyung Hyun Cheon-
dc.contributor.googleauthorSung Bae Kim-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorYoung Nyun Park-
dc.contributor.googleauthorKwang-Hyub Han-
dc.identifier.doi10.1371/journal.pone.0098689-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03500-
dc.contributor.localIdA03578-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA00570-
dc.contributor.localIdA00654-
dc.contributor.localIdA01563-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02836-
dc.contributor.localIdA02233-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid24901649-
dc.contributor.alternativeNameChun, Kyeong Hyeon-
dc.contributor.alternativeNameJung, Kyu Sik-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Sung Bae-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Sang Hoon-
dc.contributor.affiliatedAuthorChun, Kyeong Hyeon-
dc.contributor.affiliatedAuthorJung, Kyu Sik-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Sung Bae-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Sang Hoon-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.citation.volume9-
dc.citation.number6-
dc.citation.startPagee98689-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(6) : e98689, 2014-
dc.identifier.rimsid53760-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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