Cited 60 times in
Human Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 정세리 | - |
dc.date.accessioned | 2015-01-06T16:50:06Z | - |
dc.date.available | 2015-01-06T16:50:06Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98860 | - |
dc.description.abstract | Human leukocyte antigen-G (HLA-G) is known to be implicated in a tumor-driven immune escape mechanism in malignancies. The purpose of this study was to investigate HLA-G polymorphism and expression in breast cancer. HLA-G alleles were determined by direct DNA sequencing procedures from blood samples of 80 breast cancer patients and 80 healthy controls. Soluble HLA-G (sHLA-G) was measured by enzyme-linked immunosorbent assay (ELISA) from serum specimens. HLA-G expression in breast cancer lesions was also analyzed by immunohistochemistry staining. The presence of HLA-G 3′ untranslated region (UTR) 14-bp sequence was analyzed and found to be associated with reduced risk of breast cancer susceptibility based on HLA-G expression in tissues (P = 0.0407). Levels of sHLA-G were higher in the breast cancer group (median 117.2 U/mL) compared to the control group (median 10.1 U/mL, P<0.001). The area under the receiver operating characteristic curve (AU-ROC) values of sHLA-G for differentiating breast cancer from normal controls and for detecting metastasis from other stages of breast cancer were 0.89 and 0.79, respectively. HLA-G polymorphism and expression may be involved in breast carcinogenesis and sHLA-G concentrations could be used as a diagnostic marker for detecting breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e98284 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Area Under Curve | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Breast Neoplasms/genetics* | - |
dc.subject.MESH | Breast Neoplasms/metabolism | - |
dc.subject.MESH | DNA Primers/genetics | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/genetics* | - |
dc.subject.MESH | HLA-G Antigens/genetics* | - |
dc.subject.MESH | HLA-G Antigens/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Neoplasm Metastasis/genetics* | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Sequence Analysis, DNA | - |
dc.subject.MESH | Tumor Escape/genetics* | - |
dc.title | Human Leukocyte Antigen-G (HLA-G) Polymorphism and Expression in Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Seri Jeong | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Byeong-Woo Park | - |
dc.contributor.googleauthor | Younhee Park | - |
dc.contributor.googleauthor | Oh-Joong Kwon | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.identifier.doi | 10.1371/journal.pone.0098284 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A03627 | - |
dc.contributor.localId | A01117 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24870375 | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Jeong, Se Ri | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Jeong, Se Ri | - |
dc.contributor.affiliatedAuthor | Kim, Hyon Suk | - |
dc.citation.volume | 9 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e98284 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(5) : e98284, 2014 | - |
dc.identifier.rimsid | 38832 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.