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Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy

DC FieldValueLanguage
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.date.accessioned2015-01-06T16:49:44Z-
dc.date.available2015-01-06T16:49:44Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98848-
dc.description.abstractMultiple system atrophy (MSA) is an adult-onset, sporadic neurodegenerative disease. Because the prognosis of MSA is fatal, neuroprotective or regenerative strategies may be invaluable in MSA treatment. Previously, we obtained clinical and imaging evidence that mesenchymal stem cell (MSC) treatment could have a neuroprotective role in MSA patients. In the present study, we evaluated the effects of MSC therapy on longitudinal changes in subcortical deep gray matter volumes and cortical thickness and their association with cognitive performance. Clinical and imaging data were obtained from our previous randomized trial of autologous MSC in MSA patients. During 1-year follow-up, we assessed longitudinal differences in automatic segmentation-based subcortical deep gray matter volumes and vertex-wise cortical thickness between placebo (n = 15) and MSC groups (n = 11). Next, we performed correlation analysis between the changes in cortical thickness and changes in the Korean version of the Montreal Cognitive Assessment (MoCA) scores and cognitive performance of each cognitive subdomain using a multiple, comparison correction. There were no significant differences in age at baseline, age at disease onset, gender ratio, disease duration, clinical severity, MoCA score, or education level between the groups. The automated subcortical volumetric analysis revealed that the changes in subcortical deep gray matter volumes of the caudate, putamen, and thalamus did not differ significantly between the groups. The areas of cortical thinning over time in the placebo group were more extensive, including the frontal, temporal, and parietal areas, whereas these areas in the MSC group were less extensive. Correlation analysis indicated that declines in MoCA scores and phonemic fluency during the follow-up period were significantly correlated with cortical thinning of the frontal and posterior temporal areas and anterior temporal areas in MSA patients, respectively. In contrast, no significant correlations were observed in the MSC group. These results suggest that MSC treatment in patients with MSA may modulate cortical thinning over time and related cognitive performance, inferring a future therapeutic candidate for cognitive disorders.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfFRONTIERS IN AGING NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorHyuk Jin Yun-
dc.contributor.googleauthorSook K. Song-
dc.contributor.googleauthorJi Hyun Ham-
dc.contributor.googleauthorJin Yong Hong-
dc.contributor.googleauthorJi E. Lee-
dc.contributor.googleauthorHye S. Lee-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.3389/fnagi.2014.00118-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.contributor.localIdA03210-
dc.relation.journalcodeJ00908-
dc.identifier.eissn1663-4365-
dc.identifier.pmid24982631-
dc.subject.keywordclinical trial-
dc.subject.keywordcognition-
dc.subject.keywordcortical thickness-
dc.subject.keywordmesenchymal stem cells-
dc.subject.keywordmultiple system atrophy-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.citation.volume6-
dc.citation.startPage118-
dc.identifier.bibliographicCitationFRONTIERS IN AGING NEUROSCIENCE, Vol.6 : 118, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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