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In vivo emergence of colistin resistance in Acinetobacter baumannii clinical isolates of sequence type 357 during colistin treatment

DC FieldValueLanguage
dc.contributor.author용동은-
dc.contributor.author이경원-
dc.contributor.author정석훈-
dc.date.accessioned2015-01-06T16:48:38Z-
dc.date.available2015-01-06T16:48:38Z-
dc.date.issued2014-
dc.identifier.issn0732-8893-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98813-
dc.description.abstractThis study was performed to investigate the mechanisms of in vivo acquisition of colistin resistance in A. baumannii during colistin treatment. Three colistin-susceptible/resistant pairs of A. baumannii were recovered from patients who underwent colistin treatment. All of the 6 isolates included in this study shared an identical sequence type (ST), ST375, and they showed identical SmaI-macrorestriction patterns by pulsed-field gel electrophoresis. The individual colistin-resistant isolates harbored distinct mutations in the pmrB gene. Mutations detected in the pmrB gene were Ala227Val, Pro233Ser, and frame shift from Phe26. In matrix-assisted laser desorption ionization–time of flight analysis, colistin-resistant isolates were different from their colistin-susceptible counterparts, and they showed additional distinct peaks at 1852 m/z, 1937 m/z, 1954 m/z, 1975 m/z, 2034 m/z, and 2157 m/z. In vivo selection of colistin-resistant A. baumannii occurred independently in strains of ST357 during colistin treatment, and the strains acquired colistin resistance via mutations in the pmrB gene resulting in modification of lipid A components.-
dc.description.statementOfResponsibilityopen-
dc.format.extent362~366-
dc.relation.isPartOfDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcinetobacter Infections/drug therapy*-
dc.subject.MESHAcinetobacter Infections/microbiology*-
dc.subject.MESHAcinetobacter baumannii/classification-
dc.subject.MESHAcinetobacter baumannii/drug effects*-
dc.subject.MESHAcinetobacter baumannii/genetics-
dc.subject.MESHAcinetobacter baumannii/isolation & purification*-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/therapeutic use*-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHColistin/therapeutic use*-
dc.subject.MESHDrug Resistance, Bacterial*-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field-
dc.subject.MESHFemale-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMolecular Typing-
dc.subject.MESHMutation-
dc.subject.MESHPolymorphism, Restriction Fragment Length-
dc.subject.MESHSelection, Genetic-
dc.subject.MESHSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization-
dc.subject.MESHTranscription Factors/genetics-
dc.titleIn vivo emergence of colistin resistance in Acinetobacter baumannii clinical isolates of sequence type 357 during colistin treatment-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorYoonjung Kim-
dc.contributor.googleauthorIl Kwon Bae-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorDongeun Yong-
dc.contributor.googleauthorKyungwon Lee-
dc.identifier.doi10.1016/j.diagmicrobio.2014.03.027-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02423-
dc.contributor.localIdA02649-
dc.contributor.localIdA03619-
dc.relation.journalcodeJ00731-
dc.identifier.eissn1879-0070-
dc.identifier.pmid24809861-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0732889314001606-
dc.subject.keywordLipid A-
dc.subject.keywordLipopolysaccharide-
dc.subject.keywordPhosphoethanolamine-
dc.subject.keywordPmrB gene-
dc.subject.keywordPolymyxins-
dc.contributor.alternativeNameYong, Dong Eun-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorYong, Dong Eun-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.rights.accessRightsfree-
dc.citation.volume79-
dc.citation.number3-
dc.citation.startPage362-
dc.citation.endPage366-
dc.identifier.bibliographicCitationDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.79(3) : 362-366, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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