Cited 39 times in
In vivo emergence of colistin resistance in Acinetobacter baumannii clinical isolates of sequence type 357 during colistin treatment
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2015-01-06T16:48:38Z | - |
dc.date.available | 2015-01-06T16:48:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98813 | - |
dc.description.abstract | This study was performed to investigate the mechanisms of in vivo acquisition of colistin resistance in A. baumannii during colistin treatment. Three colistin-susceptible/resistant pairs of A. baumannii were recovered from patients who underwent colistin treatment. All of the 6 isolates included in this study shared an identical sequence type (ST), ST375, and they showed identical SmaI-macrorestriction patterns by pulsed-field gel electrophoresis. The individual colistin-resistant isolates harbored distinct mutations in the pmrB gene. Mutations detected in the pmrB gene were Ala227Val, Pro233Ser, and frame shift from Phe26. In matrix-assisted laser desorption ionization–time of flight analysis, colistin-resistant isolates were different from their colistin-susceptible counterparts, and they showed additional distinct peaks at 1852 m/z, 1937 m/z, 1954 m/z, 1975 m/z, 2034 m/z, and 2157 m/z. In vivo selection of colistin-resistant A. baumannii occurred independently in strains of ST357 during colistin treatment, and the strains acquired colistin resistance via mutations in the pmrB gene resulting in modification of lipid A components. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 362~366 | - |
dc.relation.isPartOf | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acinetobacter Infections/drug therapy* | - |
dc.subject.MESH | Acinetobacter Infections/microbiology* | - |
dc.subject.MESH | Acinetobacter baumannii/classification | - |
dc.subject.MESH | Acinetobacter baumannii/drug effects* | - |
dc.subject.MESH | Acinetobacter baumannii/genetics | - |
dc.subject.MESH | Acinetobacter baumannii/isolation & purification* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anti-Bacterial Agents/therapeutic use* | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Colistin/therapeutic use* | - |
dc.subject.MESH | Drug Resistance, Bacterial* | - |
dc.subject.MESH | Electrophoresis, Gel, Pulsed-Field | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Molecular Typing | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Polymorphism, Restriction Fragment Length | - |
dc.subject.MESH | Selection, Genetic | - |
dc.subject.MESH | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | - |
dc.subject.MESH | Transcription Factors/genetics | - |
dc.title | In vivo emergence of colistin resistance in Acinetobacter baumannii clinical isolates of sequence type 357 during colistin treatment | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yoonjung Kim | - |
dc.contributor.googleauthor | Il Kwon Bae | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2014.03.027 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J00731 | - |
dc.identifier.eissn | 1879-0070 | - |
dc.identifier.pmid | 24809861 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0732889314001606 | - |
dc.subject.keyword | Lipid A | - |
dc.subject.keyword | Lipopolysaccharide | - |
dc.subject.keyword | Phosphoethanolamine | - |
dc.subject.keyword | PmrB gene | - |
dc.subject.keyword | Polymyxins | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Jeong, Seok Hoon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 79 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 362 | - |
dc.citation.endPage | 366 | - |
dc.identifier.bibliographicCitation | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.79(3) : 362-366, 2014 | - |
dc.identifier.rimsid | 39259 | - |
dc.type.rims | ART | - |
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