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Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

Authors
 Keunwook Lee  ;  Hyekyung Hwang  ;  Ki Taek Nam 
Citation
 GUT AND LIVER, Vol.8(2) : 131-139, 2014 
Journal Title
 GUT AND LIVER 
ISSN
 1976-2283 
Issue Date
2014
MeSH
Adaptive Immunity/immunology* ; B-Lymphocytes/immunology ; Cytokines/immunology ; Gastritis/immunology ; Helicobacter Infections/immunology ; Helicobacter pylori/immunology ; Humans ; Immunity, Innate/immunology* ; Immunotherapy/methods ; Receptors, Cytokine/immunology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/immunology* ; Stomach Neoplasms/therapy ; T-Lymphocytes/immunology ; Tumor Microenvironment/immunology*
Keywords
Helicobacter pylori ; Immune cells ; Inflammation ; Stomach neoplasms
Abstract
Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely associated with the initiation, progression, and metastasis of many tumors, including those of gastric cancer. In addition, approximately 60% of the world's population is colonized by Helicobacter pylori, which accounts for more than 50% of gastric cancers. While the role of inflammation in intestinal and colonic cancers is relatively well defined, its role in stomach neoplasia is still unclear because of the limited access of pathogens to the acidic environment and the technical difficulties isolating and characterizing immune cells in the stomach, especially in animal models. In this review, we will provide recent updates addressing how inflammation is involved in gastric malignancies, and what immune characteristics regulate the pathogenesis of stomach cancer. Also, we will discuss potential therapeutics that target the immune system for the efficient treatment of gastric cancer.
Files in This Item:
T201401477.pdf Download
DOI
10.5009/gnl.2014.8.2.131
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98801
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