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Can a Biomarker-Based Scoring System Predict Pathologic Complete Response After Preoperative Chemoradiotherapy for Rectal Cancer?

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.contributor.author김남규-
dc.contributor.author김호근-
dc.contributor.author민병소-
dc.contributor.author백승혁-
dc.contributor.author안중배-
dc.contributor.author이강영-
dc.contributor.author허혁-
dc.date.accessioned2015-01-06T16:47:48Z-
dc.date.available2015-01-06T16:47:48Z-
dc.date.issued2014-
dc.identifier.issn0012-3706-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98786-
dc.description.abstractBACKGROUND: Numerous molecular markers have been investigated as potential predictors of tumor responses to preoperative chemoradiotherapy (preCRT) for rectal cancer. OBJECTIVE: To develop a system in which biomarkers are used to predict the likelihood of a pathologic complete response (pCR) to preCRT. DESIGN & SETTING: This is a retrospective analysis of tumor specimens collected prior to preCRT from 81 patients who underwent curative resection for primary rectal adenocarcinoma between June 2008 and February 2012. MAIN OUTCOME MEASURES: Using tissue microarrays and immunohistochemistry, expression levels of twelve candidate biomarkers (p53, p21, Bcl2, Bax, EGFR, Cox-2, MLH-1, MSH-2, Ku70, VEGF, TS, Ki-67) were evaluated in paraffin-embedded tumor samples collected before preCRT. The correlation between biomarker expression levels and the pathologic response to preCRT was assessed based on histopathological staging (pTNM) and tumor regression grade (TRG). RESULTS: Expression levels of 4 biomarkers (p53, VEGF, p21, Ki67) correlated with pCR. Patients showing low expression of p53 and/or high expression of VEGF, p21, and Ki67 exhibited a significantly greater pCR rate. A scoring system devised so that one point was given for each biomarker whose expression level correlated with pCR (score range: 0-4) showed that 1 of 26 patients with scores of 0 to 1 achieved pCR, whereas 26 of 55 patients with scores of 2 to 4 achieved pCR (3.8% vs. 47.3%, p < 0.001). For prediction of pCR, the scoring system showed 96.3% sensitivity, 46.3% specificity, a 47.3% positive predictive value, and a 96.2% negative predictive value. LIMITATIONS: Immunohistochemistry has limitations related to reproducibility and the ability to provide quantitative information. In addition, this study lacks test and validation sets. CONCLUSIONS: Expression levels of 4 biomarkers correlated with pCR after preCRT for rectal cancer. A scoring system based on levels of biomarker expression showed good sensitivity and negative predictive value for pCR.-
dc.description.statementOfResponsibilityopen-
dc.format.extent592~601-
dc.relation.isPartOfDISEASES OF THE COLON & RECTUM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHAdenocarcinoma/therapy*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBiopsy-
dc.subject.MESHChemoradiotherapy*-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFluorouracil/therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHLeucovorin/therapeutic use-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPolymerase Chain Reaction-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRadiotherapy Dosage-
dc.subject.MESHRectal Neoplasms/pathology*-
dc.subject.MESHRectal Neoplasms/surgery-
dc.subject.MESHRectal Neoplasms/therapy*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSigmoidoscopy-
dc.subject.MESHTreatment Outcome-
dc.titleCan a Biomarker-Based Scoring System Predict Pathologic Complete Response After Preoperative Chemoradiotherapy for Rectal Cancer?-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHyuk Hur-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorByung Soh Min-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorKang Young Lee-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorHoguen Kim-
dc.identifier.doi10.1097/DCR.0000000000000109-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00273-
dc.contributor.localIdA00353-
dc.contributor.localIdA01183-
dc.contributor.localIdA01402-
dc.contributor.localIdA01827-
dc.contributor.localIdA02262-
dc.contributor.localIdA02640-
dc.contributor.localIdA04373-
dc.relation.journalcodeJ00744-
dc.identifier.eissn1530-0358-
dc.identifier.pmid24819099-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00003453-201405000-00006&LSLINK=80&D=ovft-
dc.subject.keywordRectal cancer-
dc.subject.keywordChemoradiotherapy-
dc.subject.keywordPathologic complete response-
dc.subject.keywordBiomarkers-
dc.subject.keywordPredictive system-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNameBaik, Seung Hyuk-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorBaik, Seung Hyuk-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.rights.accessRightsfree-
dc.citation.volume57-
dc.citation.number5-
dc.citation.startPage592-
dc.citation.endPage601-
dc.identifier.bibliographicCitationDISEASES OF THE COLON & RECTUM, Vol.57(5) : 592-601, 2014-
dc.identifier.rimsid39245-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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