Cited 10 times in
Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유철주 | - |
dc.date.accessioned | 2015-01-06T16:46:53Z | - |
dc.date.available | 2015-01-06T16:46:53Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1397-3142 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98756 | - |
dc.description.abstract | This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II–IV graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91 × 105/kg of infused CD34 + cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p = 0.04) and OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 221~229 | - |
dc.relation.isPartOf | PEDIATRIC TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Anemia, Aplastic/therapy | - |
dc.subject.MESH | Antigens, CD34/metabolism | - |
dc.subject.MESH | Bone Marrow Diseases | - |
dc.subject.MESH | Brain Diseases, Metabolic, Inborn/therapy | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cord Blood Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft vs Host Disease/etiology | - |
dc.subject.MESH | HLA Antigens/metabolism | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal/therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Deficiency Syndromes/therapy | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Unrelated Donors | - |
dc.title | Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Meerim Park | - |
dc.contributor.googleauthor | Young Ho Lee | - |
dc.contributor.googleauthor | Hae-Ryong Kang | - |
dc.contributor.googleauthor | Ji Won Lee | - |
dc.contributor.googleauthor | Hyoung Jin Kang | - |
dc.contributor.googleauthor | Kyung Duk Park | - |
dc.contributor.googleauthor | Hee Young Shin | - |
dc.contributor.googleauthor | Hyo Seop Ahn | - |
dc.contributor.googleauthor | Hee Jo Baek | - |
dc.contributor.googleauthor | Hoon Kook | - |
dc.contributor.googleauthor | Tai Ju Hwang | - |
dc.contributor.googleauthor | Jae Wook Lee | - |
dc.contributor.googleauthor | Nack-Gyun Chung | - |
dc.contributor.googleauthor | Bin Cho | - |
dc.contributor.googleauthor | Hack-Ki Kim | - |
dc.contributor.googleauthor | Soo Hyun Lee | - |
dc.contributor.googleauthor | Keon Hee Yoo | - |
dc.contributor.googleauthor | Ki Woong Sung | - |
dc.contributor.googleauthor | Hong Hoe Koo | - |
dc.contributor.googleauthor | Kyung Nam Koh | - |
dc.contributor.googleauthor | Ho Joon Im | - |
dc.contributor.googleauthor | Jong Jin Seo | - |
dc.contributor.googleauthor | Jun Eun Park | - |
dc.contributor.googleauthor | Yeon Jung Lim | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jae Min Lee | - |
dc.contributor.googleauthor | Jeong Ok Hah | - |
dc.identifier.doi | 10.1111/petr.12213 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02524 | - |
dc.relation.journalcode | J02495 | - |
dc.identifier.eissn | 1399-3046 | - |
dc.identifier.pmid | 24372660 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/petr.12213/abstract | - |
dc.subject.keyword | adolescents | - |
dc.subject.keyword | children | - |
dc.subject.keyword | non-malignant disease | - |
dc.subject.keyword | unrelated cord blood transplantation | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 229 | - |
dc.identifier.bibliographicCitation | PEDIATRIC TRANSPLANTATION, Vol.18(2) : 221-229, 2014 | - |
dc.identifier.rimsid | 38586 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.