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Unrelated donor cord blood transplantation for non-malignant disorders in children and adolescents

DC FieldValueLanguage
dc.contributor.author유철주-
dc.date.accessioned2015-01-06T16:46:53Z-
dc.date.available2015-01-06T16:46:53Z-
dc.date.issued2014-
dc.identifier.issn1397-3142-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98756-
dc.description.abstractThis study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II–IV graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91 × 105/kg of infused CD34 + cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p = 0.04) and OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases.-
dc.description.statementOfResponsibilityopen-
dc.format.extent221~229-
dc.relation.isPartOfPEDIATRIC TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAnemia, Aplastic/therapy-
dc.subject.MESHAntigens, CD34/metabolism-
dc.subject.MESHBone Marrow Diseases-
dc.subject.MESHBrain Diseases, Metabolic, Inborn/therapy-
dc.subject.MESHChild-
dc.subject.MESHChild, Preschool-
dc.subject.MESHCord Blood Stem Cell Transplantation/methods*-
dc.subject.MESHFemale-
dc.subject.MESHGraft vs Host Disease/etiology-
dc.subject.MESHHLA Antigens/metabolism-
dc.subject.MESHHemoglobinuria, Paroxysmal/therapy-
dc.subject.MESHHumans-
dc.subject.MESHImmunologic Deficiency Syndromes/therapy-
dc.subject.MESHInfant-
dc.subject.MESHMale-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHRegistries-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUnrelated Donors-
dc.titleUnrelated donor cord blood transplantation for non-malignant disorders in children and adolescents-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorMeerim Park-
dc.contributor.googleauthorYoung Ho Lee-
dc.contributor.googleauthorHae-Ryong Kang-
dc.contributor.googleauthorJi Won Lee-
dc.contributor.googleauthorHyoung Jin Kang-
dc.contributor.googleauthorKyung Duk Park-
dc.contributor.googleauthorHee Young Shin-
dc.contributor.googleauthorHyo Seop Ahn-
dc.contributor.googleauthorHee Jo Baek-
dc.contributor.googleauthorHoon Kook-
dc.contributor.googleauthorTai Ju Hwang-
dc.contributor.googleauthorJae Wook Lee-
dc.contributor.googleauthorNack-Gyun Chung-
dc.contributor.googleauthorBin Cho-
dc.contributor.googleauthorHack-Ki Kim-
dc.contributor.googleauthorSoo Hyun Lee-
dc.contributor.googleauthorKeon Hee Yoo-
dc.contributor.googleauthorKi Woong Sung-
dc.contributor.googleauthorHong Hoe Koo-
dc.contributor.googleauthorKyung Nam Koh-
dc.contributor.googleauthorHo Joon Im-
dc.contributor.googleauthorJong Jin Seo-
dc.contributor.googleauthorJun Eun Park-
dc.contributor.googleauthorYeon Jung Lim-
dc.contributor.googleauthorChuhl Joo Lyu-
dc.contributor.googleauthorJae Min Lee-
dc.contributor.googleauthorJeong Ok Hah-
dc.identifier.doi10.1111/petr.12213-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02524-
dc.relation.journalcodeJ02495-
dc.identifier.eissn1399-3046-
dc.identifier.pmid24372660-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/petr.12213/abstract-
dc.subject.keywordadolescents-
dc.subject.keywordchildren-
dc.subject.keywordnon-malignant disease-
dc.subject.keywordunrelated cord blood transplantation-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.rights.accessRightsfree-
dc.citation.volume18-
dc.citation.number2-
dc.citation.startPage221-
dc.citation.endPage229-
dc.identifier.bibliographicCitationPEDIATRIC TRANSPLANTATION, Vol.18(2) : 221-229, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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