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The burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease.

DC FieldValueLanguage
dc.contributor.author함지현-
dc.contributor.author홍진용-
dc.contributor.author선우문경-
dc.contributor.author손영호-
dc.contributor.author이지은-
dc.contributor.author이필휴-
dc.date.accessioned2015-01-06T16:46:51Z-
dc.date.available2015-01-06T16:46:51Z-
dc.date.issued2014-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98755-
dc.description.abstractBACKGROUND AND PURPOSE: To evaluate whether white matter hyperintensities (WMHs) may act as an independent predictor for progression of cognitive status, the authors analyzed the longitudinal effects of WMHs on cognitive dysfunction in non-demented patients with Parkinson's disease (PD). METHODS: A total of 111 patients with PD were enrolled, including subjects with mild cognitive impairment (MCI, n = 65) and cognitively normal subjects (CN, n = 46). These individuals were classified as MCI converters (n = 22) or MCI non-converters (n = 43) and CN converters (n = 18) or CN non-converters (n = 28) based on whether they were subsequently diagnosed with PD dementia or PD-MCI during a minimum 24-month follow-up. The WMH burden and the Cholinergic Pathway Hyperintensities Scale (CHIPS) and their relationships to longitudinal changes in cognitive performance were examined. RESULTS: PD-MCI converters had larger WMH volume (14421.0 vs. 5180.4, P < 0.001) and higher CHIPS score (22.6 vs. 11.2, P = 0.001) compared with PD-MCI non-converters. Logistic regression analysis revealed in patients with PD-MCI that WMH volume (odds ratio 1.616, P = 0.009) and CHIPS score (odds ratio 1.084, P = 0.007) were independently associated with PD dementia conversion. However, WMH volume and CHIPS score did not differ between PD-CN converters and PD-CN non-converters. In patients with PD-MCI, both WMH volume and CHIPS score were closely associated with longitudinal decline in general cognition, semantic fluency and Stroop test scores. CONCLUSIONS: The present study demonstrates that WMH burden is a significant predictor of conversion from PD-MCI to PD dementia and is related to ongoing decline in frontal-lobe-based cognitive performance.-
dc.description.statementOfResponsibilityopen-
dc.format.extent922~928-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCognition-
dc.subject.MESHCognitive Dysfunction/complications-
dc.subject.MESHCognitive Dysfunction/pathology*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/pathology*-
dc.subject.MESHWhite Matter/pathology*-
dc.titleThe burden of white matter hyperintensities is a predictor of progressive mild cognitive impairment in patients with Parkinson's disease.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorM. K. Sunwoo-
dc.contributor.googleauthorS. Jeon-
dc.contributor.googleauthorJ. H. Ham-
dc.contributor.googleauthorJ. Y. Hong-
dc.contributor.googleauthorJ. E. Lee-
dc.contributor.googleauthorJ.-M. Lee-
dc.contributor.googleauthorY. H. Sohn-
dc.contributor.googleauthorP. H. Lee-
dc.identifier.doi10.1111/ene.12412-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04338-
dc.contributor.localIdA04442-
dc.contributor.localIdA01935-
dc.contributor.localIdA01982-
dc.contributor.localIdA03270-
dc.contributor.localIdA03210-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid24661277-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ene.12412/abstract-
dc.subject.keywordParkinson's disease-
dc.subject.keyworddementia converters-
dc.subject.keywordwhite matter hyperintensities-
dc.contributor.alternativeNameHam, Jee Hyun-
dc.contributor.alternativeNameHong, Jin Yong-
dc.contributor.alternativeNameSunwoo, Mun Kyung-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Ji Eun-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorHam, Jee Hyun-
dc.contributor.affiliatedAuthorHong, Jin Yong-
dc.contributor.affiliatedAuthorSunwoo, Mun Kyung-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Ji Eun-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number6-
dc.citation.startPage922-
dc.citation.endPage928-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.21(6) : 922-928, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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