Cited 44 times in
The changes of PCR ribotype and antimicrobial resistance of Clostridium difficile in a tertiary care hospital over 10 years
DC Field | Value | Language |
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dc.contributor.author | 김희정 | - |
dc.contributor.author | 이경원 | - |
dc.contributor.author | 이양순 | - |
dc.date.accessioned | 2015-01-06T16:46:38Z | - |
dc.date.available | 2015-01-06T16:46:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98748 | - |
dc.description.abstract | The aims of this study were to investigate any change in PCR ribotypes and to determine the antimicrobial resistance of common PCR ribotypes over a 10-year period in a tertiary care hospital. We conducted PCR ribotyping, antimicrobial susceptibility testing and DNA gyrase sequencing to identify changes in 1407 Clostridium difficile non-duplicated isolates obtained between 2000 and 2009. A total of 74 different ribotypes were found. The most prevalent ribotype was ribotype 001 (26.1 %). The prevalence of ribotype 017 was 17 % and that of ribotype 014/020 was 9.6 %. Ribotyping showed that the prevalence of ribotype 001 decreased and the prevalence of ribotypes 017, 014/020 and 018 increased over the 10 years. Antimicrobial resistance rates in prevalent ribotypes were: clindamycin, 81 %; cefotetan, 19 %; moxifloxacin, 42 %; imipenem, 8 %; ciprofloxacin, 100 % and erythromycin, 80 %. Ribotype 018 showed greater antimicrobial resistance than other ribotypes. All ribotype 018 strains showing moxifloxacin resistance had a substitution of a gyrA coding amino acid (Thr82 to Ile). This study will help the understanding of PCR ribotype trends and antimicrobial resistance of C. difficile in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 819~823 | - |
dc.relation.isPartOf | JOURNAL OF MEDICAL MICROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.MESH | Bacterial Toxins/genetics | - |
dc.subject.MESH | Bacterial Toxins/metabolism | - |
dc.subject.MESH | Clostridium difficile/drug effects* | - |
dc.subject.MESH | Clostridium difficile/genetics* | - |
dc.subject.MESH | DNA Gyrase/genetics | - |
dc.subject.MESH | DNA Gyrase/metabolism | - |
dc.subject.MESH | Drug Resistance, Bacterial* | - |
dc.subject.MESH | Gene Expression Regulation, Bacterial/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Polymerase Chain Reaction/methods* | - |
dc.subject.MESH | Ribotyping* | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Time Factors | - |
dc.title | The changes of PCR ribotype and antimicrobial resistance of Clostridium difficile in a tertiary care hospital over 10 years | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jong-Han Lee | - |
dc.contributor.googleauthor | Yangsoon Lee | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Thomas V. Riley | - |
dc.contributor.googleauthor | Heejung Kim | - |
dc.identifier.doi | 10.1099/jmm.0.072082-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02649 | - |
dc.contributor.localId | A02947 | - |
dc.contributor.localId | A01219 | - |
dc.relation.journalcode | J01583 | - |
dc.identifier.eissn | 1473-5644 | - |
dc.identifier.pmid | 24696516 | - |
dc.identifier.url | http://jmm.sgmjournals.org/content/63/Pt_6/819 | - |
dc.contributor.alternativeName | Kim, Hee Jung | - |
dc.contributor.alternativeName | Lee, Kyung Won | - |
dc.contributor.alternativeName | Lee, Yang Soon | - |
dc.contributor.affiliatedAuthor | Lee, Kyung Won | - |
dc.contributor.affiliatedAuthor | Lee, Yang Soon | - |
dc.contributor.affiliatedAuthor | Kim, Heejung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 6 | - |
dc.citation.number | 63 | - |
dc.citation.startPage | 819 | - |
dc.citation.endPage | 823 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICAL MICROBIOLOGY, Vol.6(63) : 819-823, 2014 | - |
dc.identifier.rimsid | 38580 | - |
dc.type.rims | ART | - |
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