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Cited 64 times in

Effects of botulinum toxin on jaw motor events during sleep in sleep bruxism patients: a polysomnographic evaluation

DC Field Value Language
dc.contributor.author김성택-
dc.contributor.author허경-
dc.date.accessioned2015-01-06T16:45:31Z-
dc.date.available2015-01-06T16:45:31Z-
dc.date.issued2014-
dc.identifier.issn1550-9389-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98711-
dc.description.abstractSTUDY OBJECTIVES: To investigate the effects of botulinum toxin type A (BoNT-A) injection on jaw motor episodes during sleep in patients with or without orofacial pain who did not respond to oral splint treatment. METHODS: Twenty subjects with a clinical diagnosis of SB completed this study. Ten subjects received bilateral BoNT-A injections (25 U per muscle) into the masseter muscles only (group A), and the other 10 received the injections into both the masseter and temporalis muscles (group B). Video-polysomnographic (vPSG) recordings were made before and at 4 weeks after injection. Rhythmic masticatory muscle activity (RMMA) and orofacial activity (OFA) were scored and analyzed for several parameters (e.g., frequency of episodes, bursts per episode, episode duration). The peak amplitude of electromyographic (EMG) activity in the two muscles was also measured. RESULTS: BoNT-A injection did not reduce the frequency, number of bursts, or duration for RMMA episodes in the two groups. The injection decreased the peak amplitude of EMG burst of RMMA episodes in the injected muscles (p < 0.001, repeated measure ANOVA) in both groups. At 4 weeks after injection, 9 subjects self-reported reduction of tooth grinding and 18 subjects self-reported reduction of morning jaw stiffness. CONCLUSIONS: A single BoNT-A injection is an effective strategy for controlling SB for at least a month. It reduces the intensity rather than the generation of the contraction in jaw-closing muscles. Future investigations on the efficacy and safety in larger samples over a longer follow-up period are needed before establishing management strategies for SB with BoNT-A.-
dc.description.statementOfResponsibilityopen-
dc.format.extent291~298-
dc.relation.isPartOfJOURNAL OF CLINICAL SLEEP MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBotulinum Toxins, Type A/administration & dosage-
dc.subject.MESHBotulinum Toxins, Type A/therapeutic use*-
dc.subject.MESHElectromyography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInjections, Intramuscular-
dc.subject.MESHMale-
dc.subject.MESHMasseter Muscle/drug effects-
dc.subject.MESHMasseter Muscle/physiology-
dc.subject.MESHMasticatory Muscles/drug effects-
dc.subject.MESHMasticatory Muscles/physiology*-
dc.subject.MESHMovement/drug effects-
dc.subject.MESHMovement/physiology-
dc.subject.MESHPolysomnography-
dc.subject.MESHSleep Bruxism/drug therapy*-
dc.subject.MESHTemporal Muscle/drug effects-
dc.subject.MESHTemporal Muscle/physiology-
dc.subject.MESHVideo Recording-
dc.subject.MESHYoung Adult-
dc.titleEffects of botulinum toxin on jaw motor events during sleep in sleep bruxism patients: a polysomnographic evaluation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학)-
dc.contributor.googleauthorYoung Joo Shim-
dc.contributor.googleauthorMoon Kyu Lee-
dc.contributor.googleauthorTakafumi Kato-
dc.contributor.googleauthorHyung Uk Park-
dc.contributor.googleauthorKyoung Heo-
dc.contributor.googleauthorSeong Taek Kim-
dc.identifier.doi10.5664/jcsm.3532-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00588-
dc.contributor.localIdA04341-
dc.relation.journalcodeJ01341-
dc.identifier.eissn1550-9397-
dc.identifier.pmid24634627-
dc.subject.keywordSleep bruxism-
dc.subject.keywordbotulinum toxin-
dc.subject.keywordjaw motor activity-
dc.subject.keywordmasticatory muscle pain-
dc.subject.keywordpolysomnography-
dc.subject.keywordrhythmic masticatory muscle activity-
dc.contributor.alternativeNameKim, Seong Taek-
dc.contributor.alternativeNameHeo, Kyoung-
dc.contributor.affiliatedAuthorKim, Seong Taek-
dc.contributor.affiliatedAuthorHeo, Kyoung-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPage291-
dc.citation.endPage298-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL SLEEP MEDICINE, Vol.10(3) : 291-298, 2014-
dc.identifier.rimsid38555-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers

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