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Preoperative Chemoradiotherapy Effects on Anastomotic Leakage After Rectal Cancer Resection: A Propensity Score Matching Analysis

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author김남규-
dc.contributor.author민병소-
dc.contributor.author백승혁-
dc.contributor.author이창걸-
dc.contributor.author허혁-
dc.contributor.author장지석-
dc.date.accessioned2015-01-06T16:44:44Z-
dc.date.available2015-01-06T16:44:44Z-
dc.date.issued2014-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98685-
dc.description.abstractOBJECTIVE: To assess the effects of preoperative chemoradiotherapy (CRT) on anastomotic leakage (AL) after rectal cancer resection, using propensity score matching. BACKGROUND: Conflicting data have emerged over the last decade regarding the effect of preoperative CRT on AL. METHODS: We reviewed 1437 consecutive patients with rectal cancer who underwent low anterior resection (LAR) at our institution between 2005 and 2012. AL evaluated as grade C was the primary endpoint, as proposed by the International Study Group of Rectal Cancer in 2010. The patients were treated with (n = 360) or without (n = 1077) preoperative CRT. The total radiation dose was 50.4 Gy in 28 fractions. Multivariate and propensity score matching analyses were used to compensate for the differences in some baseline characteristics. RESULTS: The preoperative CRT group contained more patients with the following characteristics, older age, male sex, smoker, advanced stage tumor, lower/mid rectal tumor location, ultra-LAR, and diverting stoma, than the non-preoperative CRT group (all Ps < 0.05). Postoperative AL occurred in 91 patients (6.3%). Before propensity score matching, the incidence of AL in patients with or without preoperative CRT was 7.5% and 5.9%, respectively (P = 0.293). After propensity score matching, the 2 groups were nearly balanced except for the initial stage and the length of the surgeon's career, and the incidence of AL in patients with or without preoperative CRT was 7.5% and 8.1%, respectively (P = 0.781). CONCLUSIONS: We did not observe that preoperative CRT increased the risk of postoperative AL after LAR in patients with rectal cancer, using propensity score matching analysis.-
dc.description.statementOfResponsibilityopen-
dc.format.extent516~521-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnastomosis, Surgical/methods-
dc.subject.MESHAnastomotic Leak/diagnosis-
dc.subject.MESHAnastomotic Leak/epidemiology*-
dc.subject.MESHAnastomotic Leak/prevention & control-
dc.subject.MESHChemoradiotherapy-
dc.subject.MESHColonoscopy-
dc.subject.MESHDigestive System Surgical Procedures/methods*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPreoperative Care/methods*-
dc.subject.MESHPrognosis-
dc.subject.MESHPropensity Score-
dc.subject.MESHRectal Neoplasms/therapy*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTomography, X-Ray Computed-
dc.titlePreoperative Chemoradiotherapy Effects on Anastomotic Leakage After Rectal Cancer Resection: A Propensity Score Matching Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorSeung Hyuk Baik-
dc.contributor.googleauthorByung So Min-
dc.contributor.googleauthorHyuk Huh-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorWoong Sub Koom-
dc.identifier.doi10.1097/SLA.0b013e31829068c5-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00272-
dc.contributor.localIdA00273-
dc.contributor.localIdA00353-
dc.contributor.localIdA01402-
dc.contributor.localIdA01827-
dc.contributor.localIdA03240-
dc.contributor.localIdA04373-
dc.contributor.localIdA04658-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid23598382-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000658-201403000-00016&LSLINK=80&D=ovft-
dc.subject.keywordanastomotic leakage-
dc.subject.keywordlow anterior resection-
dc.subject.keywordpreoperative chemoradiotherapy-
dc.subject.keywordpropensity score matching-
dc.subject.keywordrectal cancer-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameMin, Byung Soh-
dc.contributor.alternativeNameBaik, Seung Hyuk-
dc.contributor.alternativeNameLee, Chang Geol-
dc.contributor.alternativeNameHur, Hyuk-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorMin, Byung Soh-
dc.contributor.affiliatedAuthorBaik, Seung Hyuk-
dc.contributor.affiliatedAuthorLee, Chang Geol-
dc.contributor.affiliatedAuthorHur, Hyuk-
dc.rights.accessRightsfree-
dc.citation.volume259-
dc.citation.number3-
dc.citation.startPage516-
dc.citation.endPage521-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.259(3) : 516-521, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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