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Subclinical vascular inflammation in subjects with normal weight obesity and its association with body fat: an 18F-FDG-PET/CT study.

DC Field Value Language
dc.contributor.author강신애-
dc.contributor.author경찬희-
dc.contributor.author김경래-
dc.contributor.author김소희-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author전태주-
dc.date.accessioned2015-01-06T16:44:35Z-
dc.date.available2015-01-06T16:44:35Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98680-
dc.description.abstractBACKGROUND: Although body mass index (BMI) is the most widely accepted parameter for defining obesity, recent studies have indicated a unique set of patients who exhibit normal BMI and excess body fat (BF), which is termed as normal weight obesity (NWO). Increased BF is an established risk factor for atherosclerosis. However, it is unclear whether NWO subjects already have a higher degree of vascular inflammation compared to normal weight lean (NWL) subjects; moreover, the association of BF with vascular inflammation in normal weight subjects is largely unknown. METHODS: NWO and NWL subjects (n = 82 in each group) without any history of significant vascular disease were identified from a 3-year database of consecutively recruited patients undergoing 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) at a self-referred Healthcare Promotion Program. The degree of subclinical vascular inflammation was evaluated using the mean and maximum target-to-background ratios (TBRmean and TBRmax) of the carotid artery, which were measured by 18 F-FDG-PET/CT (a noninvasive tool for assessing vascular inflammation). RESULTS: We found that metabolically dysregulation was greater in NWO subjects than in NWL subjects, with a significantly higher blood pressure, higher fasting glucose level, and worse lipid profile. Moreover, NWO subjects exhibited higher TBR than NWL subjects (TBRmean: 1.33 ± 0.16 versus 1.45 ± 0.19, p < 0.001; TBRmax: 1.52 ± 0.23 versus 1.67 ± 0.25, p < 0.001). TBR was significantly associated with total BF (TBRmean: r = 0.267, p = 0.001; TBRmax: r = 0.289, p < 0.001), age (TBRmean: r = 0.170, p = 0.029; TBRmax: r = 0.165, p = 0.035), BMI (TBRmean: r = 0.184, p = 0.018; TBRmax: r = 0.206, p = 0.008), and fasting glucose level (TBRmean: r = 0.157, p = 0.044; TBRmax: r = 0.182, p = 0.020). In multiple linear regression analysis, BF was an independent determinant of TBRmean and TBRmax, after adjusting for age, BMI, and fasting glucose level (TBRmean: regression coefficient = 0.020, p = 0.008; TBRmax: regression coefficient = 0.028, p = 0.005). Compared to NWL, NWO was also independently associated with elevated TBRmax values, after adjusting for confounding factors (odds ratio = 2.887, 95% confidence interval 1.206-6.914, p = 0.017). CONCLUSIONS: NWO is associated with a higher degree of subclinical vascular inflammation, of which BF is a major contributing factor. These results warrant investigations for subclinical atherosclerosis in NWO patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1~12-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdipose Tissue/diagnostic imaging*-
dc.subject.MESHAdult-
dc.subject.MESHArteritis/diagnostic imaging-
dc.subject.MESHBody Weight/physiology-
dc.subject.MESHCarotid Arteries/diagnostic imaging*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHFluorodeoxyglucose F18-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHObesity/diagnostic imaging*-
dc.subject.MESHPositron-Emission Tomography/methods-
dc.subject.MESHTomography, X-Ray Computed/methods-
dc.titleSubclinical vascular inflammation in subjects with normal weight obesity and its association with body fat: an 18F-FDG-PET/CT study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorShinae Kang-
dc.contributor.googleauthorChanhee Kyung-
dc.contributor.googleauthorJong Suk Park-
dc.contributor.googleauthorSohee Kim-
dc.contributor.googleauthorSeung-Pyo Lee-
dc.contributor.googleauthorMin Kyung Kim-
dc.contributor.googleauthorHye Kyung Kim-
dc.contributor.googleauthorKyung Rae Kim-
dc.contributor.googleauthorTae Joo Jeon-
dc.contributor.googleauthorChul Woo-
dc.identifier.doi10.1186/1475-2840-13-70-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00052-
dc.contributor.localIdA00107-
dc.contributor.localIdA00294-
dc.contributor.localIdA00625-
dc.contributor.localIdA02270-
dc.contributor.localIdA03557-
dc.contributor.localIdA01660-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.identifier.pmid24708764-
dc.subject.keywordNormal weight obesity-
dc.subject.keywordFat-
dc.subject.keywordAtherosclerosis-
dc.subject.keyword18 F-FDG-PET/CT-
dc.subject.keywordVascular inflammation-
dc.contributor.alternativeNameKang, Shin Ae-
dc.contributor.alternativeNameKyung, Chan Hee-
dc.contributor.alternativeNameKim, Kyung Rae-
dc.contributor.alternativeNameKim, So Hee-
dc.contributor.alternativeNamePark, Jong Suk-
dc.contributor.alternativeNameAhn, Chul Woo-
dc.contributor.alternativeNameJeon, Tae Joo-
dc.contributor.affiliatedAuthorKang, Shin Ae-
dc.contributor.affiliatedAuthorKyung, Chan Hee-
dc.contributor.affiliatedAuthorKim, Kyung Rae-
dc.contributor.affiliatedAuthorKim, So Hee-
dc.contributor.affiliatedAuthorAhn, Chul Woo-
dc.contributor.affiliatedAuthorJeon, Tae Joo-
dc.contributor.affiliatedAuthorPark, Jong Suk-
dc.citation.volume13-
dc.citation.number70-
dc.citation.startPage1-
dc.citation.endPage12-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.13(70) : 1-12, 2014-
dc.identifier.rimsid38533-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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