Cited 4 times in
Differential association of RANTES-403 and IL-1B-1464 polymorphisms on histological subtypes in male Korean patients with gastric cancer
DC Field | Value | Language |
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dc.contributor.author | 김윤정 | - |
dc.contributor.author | 이경아 | - |
dc.date.accessioned | 2015-01-06T16:44:02Z | - |
dc.date.available | 2015-01-06T16:44:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98662 | - |
dc.description.abstract | The aims of this study were to elucidate the association between RANTES-403 and an increased risk of gastric cancer in Korean males and to investigate the gene–gene interaction between IL-1B and RANTES. In total, 218 male patients with gastric cancer (114 diffuse types, 97 intestinal types, and 7 mixed types) and 377 male controls were included. RANTES-403 was genotyped, and age-adjusted odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated by logistic regression. A multifactor dimensionality reduction (MDR) test with three-way split interval validation confirmed by likelihood ratio and permutation analysis was carried out. A significant increase in the risk of gastric cancer for the intestinal-type group was observed for IL-1B-1464G carriers (OR = 2.535; 95 % CI = 1.121–5.732; P = 0.02) as well as for those with IL-1B-1464 CG (OR = 2.342; 95 % CI = 0.998–5.500; P = 0.05) or IL-1B-1464 GG (OR = 2.819; 95 % CI = 1.170–6.793; P = 0.02). For the RANTES-403 genotype, there was no significant difference in the risk of gastric cancer between the overall gastric cancer and the control groups. When further stratified according to histological types, RANTES-403A carriers (OR = 1.743; 95 % CI = 1.086–2.798; P = 0.021) or heterozygotes (OR = 1.791; 95 % CI = 1.092–2.935; P = 0.021) showed increased risk for developing diffuse-type gastric cancer. MDR revealed a three-way locus–locus interaction between RANTES-403AA, IL-1B-1464GG, and IL-1B-511CT for diffuse-type gastric cancer in Korean males. We demonstrated that RANTES-403 was significantly associated with the risk of developing diffuse-type gastric cancer in men and found a possible gene–gene interaction between RANTES and IL-1B polymorphisms in gastric cancer carcinogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 3765~3770 | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Chemokine CCL5/genetics* | - |
dc.subject.MESH | Epistasis, Genetic | - |
dc.subject.MESH | Helicobacter pylori/isolation & purification | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-1beta/genetics* | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Genetic* | - |
dc.subject.MESH | Stomach Neoplasms/etiology | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/pathology | - |
dc.title | Differential association of RANTES-403 and IL-1B-1464 polymorphisms on histological subtypes in male Korean patients with gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Juwon Kim | - |
dc.contributor.googleauthor | Jong-Won Kim | - |
dc.contributor.googleauthor | Yoonjung Kim | - |
dc.contributor.googleauthor | Kyung-A Lee | - |
dc.identifier.doi | 10.1007/s13277-013-1498-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00793 | - |
dc.contributor.localId | A02647 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 24323564 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs13277-013-1498-0 | - |
dc.subject.keyword | Gastric cancer | - |
dc.subject.keyword | l IL-1B | - |
dc.subject.keyword | RANTES | - |
dc.subject.keyword | Diffuse type | - |
dc.contributor.alternativeName | Kim, Yoon Jung | - |
dc.contributor.alternativeName | Lee, Kyung A | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Jung | - |
dc.contributor.affiliatedAuthor | Lee, Kyung A | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 3765 | - |
dc.citation.endPage | 3770 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.35(4) : 3765-3770, 2014 | - |
dc.identifier.rimsid | 38182 | - |
dc.type.rims | ART | - |
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