Cited 24 times in
Efficacy of Palonosetron Versus Ramosetron on Preventing Opioid-Based Analgesia-Related Nausea and Vomiting After Lumbar Spinal Surgery
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 노고운 | - |
dc.contributor.author | 심재광 | - |
dc.date.accessioned | 2015-01-06T16:42:38Z | - |
dc.date.available | 2015-01-06T16:42:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0362-2436 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98616 | - |
dc.description.abstract | STUDY DESIGN: A prospective, randomized, and double-blind study. OBJECTIVE: To compare the efficacy of ramosetron and palonosetron on preventing postoperative nausea and vomiting (PONV) associated with opioid-based intravenous patient-controlled analgesia (IV-PCAopioid) after lumbar spinal surgery. SUMMARY OF BACKGROUND DATA: IV-PCAopioid, an effective method to control pain after lumbar spinal surgery, accompanies PONV. Ramosetron and palonosetron are novel 5-hydroxytryptamine 3 antagonists known to have longer action duration and higher receptor affinity than their congeners, whereas their relative efficacy has not been validated yet. METHODS: One hundred ninety-six patients were randomly and evenly allocated to receive either 0.3 mg of ramosetron or 0.075 mg of palonosetron 10 minutes before the end of operation. Ramosetron or palonosetron were also added to the IV-PCAopioid, which was continuously infused for 48 hours postoperatively. The incidence and intensity of PONV were serially assessed for 72 hours postoperatively. Intensity of pain, volume of IV-PCAopioid consumption, use of rescue analgesics and antiemetics, and adverse events were also assessed. RESULTS: The overall incidence of PONV was lower in the ramosetron group than the palonosetron group (50% vs. 67%, P = 0.014) without any intergroup difference in the incidence of vomiting. Nausea intensity scores were also lower until 6 (P = 0.041) and 24 hour (P = 0.026) postoperatively in the ramosetron group than the palonosetron group. Pain intensity scores were significantly lower in the ramosetron group than the palonosetron group for 72 hours postoperatively. CONCLUSION: Ramosetron was superior to palonosetron in term of reducing the incidence and severity of nausea associated with IV-PCAopioid after lumbar spinal surgery. This favorable influence of ramosetron on PONV was translated to significant postoperative pain reduction compared with palonosetron. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | E543~E549 | - |
dc.relation.isPartOf | SPINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analgesics, Opioid/adverse effects* | - |
dc.subject.MESH | Analgesics, Opioid/therapeutic use | - |
dc.subject.MESH | Antiemetics/therapeutic use* | - |
dc.subject.MESH | Benzimidazoles/therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoquinolines/therapeutic use* | - |
dc.subject.MESH | Lumbar Vertebrae/surgery* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Orthopedic Procedures/adverse effects | - |
dc.subject.MESH | Pain Management | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/chemically induced | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/drug therapy | - |
dc.subject.MESH | Postoperative Nausea and Vomiting/prevention & control* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Quinuclidines/therapeutic use* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Efficacy of Palonosetron Versus Ramosetron on Preventing Opioid-Based Analgesia-Related Nausea and Vomiting After Lumbar Spinal Surgery | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Go Un Roh | - |
dc.contributor.googleauthor | So Young Yang | - |
dc.contributor.googleauthor | Jae Kwang Shim | - |
dc.contributor.googleauthor | Young Lan Kwak | - |
dc.identifier.doi | 10.1097/BRS.0000000000000236 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01274 | - |
dc.contributor.localId | A02205 | - |
dc.relation.journalcode | J02674 | - |
dc.identifier.eissn | 1528-1159 | - |
dc.identifier.pmid | 24480956 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00007632-201404200-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | analgesia | - |
dc.subject.keyword | patient-controlled | - |
dc.subject.keyword | anti-emetics | - |
dc.subject.keyword | palonosetron | - |
dc.subject.keyword | anti-emetics | - |
dc.subject.keyword | ramosetron | - |
dc.subject.keyword | postoperative nausea and vomiting | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.alternativeName | Roh, Go Un | - |
dc.contributor.alternativeName | Shim, Jae Kwang | - |
dc.contributor.affiliatedAuthor | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | Roh, Go Un | - |
dc.contributor.affiliatedAuthor | Shim, Jae Kwang | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 39 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 543 | - |
dc.citation.endPage | 549 | - |
dc.identifier.bibliographicCitation | SPINE, Vol.39(9) : 543-549, 2014 | - |
dc.identifier.rimsid | 38147 | - |
dc.type.rims | ART | - |
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