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Prognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions

DC Field Value Language
dc.contributor.author이정일-
dc.contributor.author한광협-
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author김자경-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이관식-
dc.date.accessioned2015-01-06T16:40:40Z-
dc.date.available2015-01-06T16:40:40Z-
dc.date.issued2014-
dc.identifier.issn0262-0898-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98553-
dc.description.abstractAlthough advanced hepatocellular carcinoma (HCC) with extrahepatic metastasis is recommended to be treated by a systemic chemotherapeutic agent without local treatment targeting the liver, studies reported that causes of death in these patients were mostly from progression of intrahepatic lesions. Thus, this study investigated prognosis and factors predicting survival in these patients so as to evaluate the role of local treatments against intrahepatic lesions when the patients already had extrahepatic metastasis. This retrospective study evaluated medical records of 277 patients with HCC and extrahepatic metastasis. The median survival was 5.9 months, and 257 patients died during the follow up. Factors affecting survival of HCC patients with extrahepatic metastasis were poor response to treatment of hepatic lesions (HR 2.207; 95 % CI; p < 0.001), applying local treatment specifically targeting intrahepatic lesions (HR 0.591; 95 % CI 0.436–0.803; p = 0.001), intrahepatic tumor size larger than 3 cm (HR 2.065; 95 % CI 1.444–2.954; p < 0.001), and ECOG performance status 2 or higher (HR 1.543; 95 % CI 1.057–2.253; p = 0.025). The patients with either complete or partial response to the therapy had 1- and 2-year survival rate of 48.8 and 12.1 % whereas patient with either stable or progressive disease had 1-year survival rate of 11.4 %. These results suggest that even in the HCC patients with extrahepatic metastasis, effective local treatment may still be beneficial for the survival especially in patients with acceptable performance status.-
dc.description.statementOfResponsibilityopen-
dc.format.extent475~482-
dc.relation.isPartOfCLINICAL & EXPERIMENTAL METASTASIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHBone Neoplasms/mortality-
dc.subject.MESHBone Neoplasms/secondary*-
dc.subject.MESHBone Neoplasms/therapy-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/secondary*-
dc.subject.MESHCarcinoma, Hepatocellular/therapy-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHepatectomy-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHLiver Neoplasms/therapy-
dc.subject.MESHLung Neoplasms/mortality-
dc.subject.MESHLung Neoplasms/secondary*-
dc.subject.MESHLung Neoplasms/therapy-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSurvival Rate-
dc.titlePrognosis of hepatocellular carcinoma patients with extrahepatic metastasis and the controllability of intrahepatic lesions-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJung Il Lee-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorKwang Hyub Han-
dc.contributor.googleauthorKwan Sik Lee-
dc.identifier.doi10.1007/s10585-014-9641-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA00852-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02666-
dc.contributor.localIdA03122-
dc.contributor.localIdA00385-
dc.relation.journalcodeJ00544-
dc.identifier.eissn1573-7276-
dc.identifier.pmid24496959-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10585-014-9641-x-
dc.subject.keywordHepatocellular carcinoma-
dc.subject.keywordMetastasis-
dc.subject.keywordSurvival-
dc.subject.keywordTreatment-
dc.contributor.alternativeNameLee, Jung Il-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorLee, Jung Il-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.rights.accessRightsfree-
dc.citation.volume31-
dc.citation.number4-
dc.citation.startPage475-
dc.citation.endPage482-
dc.identifier.bibliographicCitationCLINICAL & EXPERIMENTAL METASTASIS, Vol.31(4) : 475-482, 2014-
dc.identifier.rimsid57667-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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