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A feasibility study of a pH sensitive nanomedicine using doxorubicin loaded poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) micelles

Authors
 Eun Seong Lee  ;  Ji Hoon Kim  ;  Taehoon Sim  ;  Yu Seok Youn  ;  Beom-Jin Lee  ;  Young Taik Oh  ;  Kyung Taek Oh 
Citation
 JOURNAL OF MATERIALS CHEMISTRY B, Vol.2(9) : 1152-1159, 2014 
Journal Title
 JOURNAL OF MATERIALS CHEMISTRY B 
ISSN
 2050-750X 
Issue Date
2014
Abstract
A polyelectrolyte block copolymer, poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) (P(Asp-g-Im)-PEG), with several advantages such as an easy synthesis, having a high molecular weight and the buffer capacity of a zwitterionic polymer backbone compared to poly(histidine) backbones, was presently investigated to evaluate its feasibility as a pH sensitive anticancer nanomedicine. Doxorubicin (DOX) loaded P(Asp-g-Im)-PEG micelles (DPHAIM) were prepared by the bottom flask and diafiltration methods, forming stable pH sensitive nano-systems. DPHAIM with a 28% loading capacity displayed a pH dependent behavior with respect to drug release and cytotoxicity. At pH values below 7.0, the cumulative DOX release and cell cytotoxicity were increased compared to those at physiological pH. Animal imaging after intravenous administration of the micelles revealed their accumulation by passive targeting to tumor tissue compared to other normal tissues. This pH sensitive nanovehicle based on P(Asp-g-Im)-PEG is implicated as a promising anticancer nanomedicine with less toxicity on normal tissues for effective tumor treatment.
Full Text
http://pubs.rsc.org/en/Content/ArticleLanding/2014/TB/c3tb21379j#!divAbstract
DOI
10.1039/C3TB21379J
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/98467
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