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Pooled nucleic acid testing to identify antiretroviral treatment failure during HIV infection in Seoul, South Korea

DC Field Value Language
dc.contributor.author오동현-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author최흔-
dc.contributor.author한상훈-
dc.contributor.author구남수-
dc.contributor.author김민형-
dc.contributor.author김선빈-
dc.contributor.author김용찬-
dc.contributor.author김재경-
dc.contributor.author김준명-
dc.contributor.author김현숙-
dc.contributor.author김혜원-
dc.contributor.author송제은-
dc.contributor.author안진영-
dc.contributor.author안혜원-
dc.date.accessioned2015-01-06T16:32:44Z-
dc.date.available2015-01-06T16:32:44Z-
dc.date.issued2014-
dc.identifier.issn0036-5548-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98306-
dc.description.abstractBackground: There have been various efforts to identify less costly but still accurate methods for monitoring the response to HIV treatment. We evaluated a pooling method to determine if this could improve screening efficiency and reduce costs while maintaining accuracy in Seoul, South Korea. Methods: We conducted the first prospective study of pooled nucleic acid testing (NAT) using a 5 minipool + algorithm strategy versus individual viral load testing for patients receiving antiretroviral therapy (ART) between November 2011 and August 2012 at an urban hospital in Seoul, South Korea. The viral load assay used has a lower level of detection of 20 HIV RNA copies/ml, and the cost per assay is US$ 136. The 5 minipool +algorithm strategy was applied and 43 pooled samples were evaluated. The relative efficiency and accuracy of the pooled NAT were compared with those of individual testing. Results: Using the individual viral load assay, 15 of 215 (7%) plasma samples had more than 200 HIV RNA copies/ml. The pooled NAT using the 5 minipool + algorithm strategy was applied to 43 pooled samples; 111 tests were needed to test all samples when virologic failure was defined at HIV RNA ≥ 200 copies/ml. Therefore, 104 tests were saved over individual testing, with a relative efficiency of 0.48. When evaluating costs, a total of US$ 14,144 was saved for 215 individual samples during 10 months. The negative predictive value was 99.5% for all samples with HIV RNA ≥ 200 copies/ml. Conclusions: The pooled NAT with 5 minipool + algorithm strategy seems to be a very promising approach to effectively monitor patients receiving ART and to save resources.-
dc.description.statementOfResponsibilityopen-
dc.format.extent136~140-
dc.relation.isPartOfSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAnti-Retroviral Agents/therapeutic use*-
dc.subject.MESHDrug Monitoring/economics-
dc.subject.MESHDrug Monitoring/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHIV/genetics-
dc.subject.MESHHIV/isolation & purification*-
dc.subject.MESHHIV Infections/drug therapy*-
dc.subject.MESHHIV Infections/virology-
dc.subject.MESHHealth Care Costs-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNucleic Acids/genetics-
dc.subject.MESHNucleic Acids/isolation & purification*-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSpecimen Handling/economics-
dc.subject.MESHSpecimen Handling/methods*-
dc.subject.MESHTreatment Failure-
dc.subject.MESHViral Load/economics-
dc.subject.MESHViral Load/methods*-
dc.subject.MESHYoung Adult-
dc.titlePooled nucleic acid testing to identify antiretroviral treatment failure during HIV infection in Seoul, South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorSun Bean Kim-
dc.contributor.googleauthorHye Won Kim-
dc.contributor.googleauthorHyon-Suk Kim-
dc.contributor.googleauthorHea Won Ann-
dc.contributor.googleauthorJae Kyoung Kim-
dc.contributor.googleauthorHeun Choi-
dc.contributor.googleauthorMin Hyung Kim-
dc.contributor.googleauthorJe Eun Song-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorDong Hyun Oh-
dc.contributor.googleauthorYong Chan Kim-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJune Myung Kim-
dc.contributor.googleauthorDavey M. Smith-
dc.contributor.googleauthorJun Yong Choi-
dc.identifier.doi10.3109/00365548.2013.851415-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02361-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04227-
dc.contributor.localIdA04286-
dc.contributor.localIdA00189-
dc.contributor.localIdA00480-
dc.contributor.localIdA00547-
dc.contributor.localIdA00752-
dc.contributor.localIdA00856-
dc.contributor.localIdA00953-
dc.contributor.localIdA01176-
dc.contributor.localIdA02059-
dc.contributor.localIdA02267-
dc.contributor.localIdA02275-
dc.contributor.localIdA01117-
dc.relation.journalcodeJ02634-
dc.identifier.eissn1651-1980-
dc.identifier.pmid24228824-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/00365548.2013.851415-
dc.subject.keywordHIV-
dc.subject.keywordpooling-
dc.subject.keywordantiretroviral therapy-
dc.subject.keywordviral load-
dc.subject.keywordvirologic failure-
dc.contributor.alternativeNameOh, Dong Hyun-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameChoi, Heun-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, Min Hyung-
dc.contributor.alternativeNameKim, Sun Bean-
dc.contributor.alternativeNameKim, Yong Chan-
dc.contributor.alternativeNameKim, Jae Kyoung-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Hyon Suk-
dc.contributor.alternativeNameKim, Hye Won-
dc.contributor.alternativeNameSong, Je Eun-
dc.contributor.alternativeNameAhn, Jin Young-
dc.contributor.alternativeNameAnn, Hea Won-
dc.contributor.affiliatedAuthorOh, Dong Hyun-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorChoi, Heun-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, Min Hyung-
dc.contributor.affiliatedAuthorKim, Sun Bean-
dc.contributor.affiliatedAuthorKim, Yong Chan-
dc.contributor.affiliatedAuthorKim, Jae Kyoung-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorKim, Hye Won-
dc.contributor.affiliatedAuthorSong, Je Eun-
dc.contributor.affiliatedAuthorAhn, Jin Young-
dc.contributor.affiliatedAuthorAnn, Hea Won-
dc.contributor.affiliatedAuthorKim, Hyon Suk-
dc.rights.accessRightsfree-
dc.citation.volume46-
dc.citation.number2-
dc.citation.startPage136-
dc.citation.endPage140-
dc.identifier.bibliographicCitationSCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, Vol.46(2) : 136-140, 2014-
dc.identifier.rimsid51828-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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