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Charlson Comorbidity Index Is an Important Prognostic Factor for Long-Term Survival Outcomes in Korean Men with Prostate Cancer after Radical Prostatectomy

DC FieldValueLanguage
dc.contributor.author나군호-
dc.contributor.author양승철-
dc.contributor.author이주용-
dc.contributor.author조강수-
dc.contributor.author조남훈-
dc.contributor.author최영득-
dc.contributor.author홍성준-
dc.date.accessioned2015-01-06T16:31:57Z-
dc.date.available2015-01-06T16:31:57Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98283-
dc.description.abstractPURPOSE: To analyze overall survival (OS), prostate cancer (PCa)-specific survival (PCaSS), and non-PCaSS according to the Charlson Comorbidity Index (CCI) after radical prostatectomy (RP) for PCa. MATERIALS AND METHODS: Data from 336 patients who had RP for PCa between 1992 and 2005 were analyzed. Data included age, preoperative prostate-specific antigen (PSA), prostate volume, clinical stage, and pathologic stage. Pre-existing comorbidities were evaluated by the CCI, and patients were classified into two CCI score categories (0, ≥1). RESULTS: The mean age of patients was 64.31±6.12 years. The median PSA value (interquartile range, IQR) was 11.30 (7.35 and 21.02) ng/mL with a median follow-up period (IQR) of 96.0 (85.0 and 121.0) months. The mean CCI was 0.28 (0-4). Five-year OS, PCaSS, and non-PCaSS were 91.7%, 96.3%, and 95.2%, respectively. Ten-year OS, PCaSS, and non-PCaSS were 81.9%, 92.1%, and 88.9%, respectively. The CCI had a significant influence on OS (p=0.022) and non-PCaSS (p=0.008), but not on PCaSS (p=0.681), by log-rank test. In multivariate Cox regression analysis, OS was independently associated with the CCI [hazard ratio (HR)=1.907, p=0.025] and Gleason score (HR=2.656, p<0.001). PCaSS was independently associated with pathologic N stage (HR=2.857, p=0.031), pathologic T stage (HR=3.775, p=0.041), and Gleason score (HR=4.308, p=0.001). Non-PCaSS had a significant association only with the CCI (HR=2.540, p=0.009). CONCLUSION: The CCI was independently associated with both OS and non-PCaSS after RP, but the CCI had no impact on PCaSS. The comorbidities of a patient should be considered before selecting RP as a curative modality for PCa.-
dc.description.statementOfResponsibilityopen-
dc.format.extent316~323-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHComorbidity-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProstatectomy/methods*-
dc.subject.MESHProstatic Neoplasms/epidemiology*-
dc.subject.MESHProstatic Neoplasms/mortality*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHSurvival Rate-
dc.titleCharlson Comorbidity Index Is an Important Prognostic Factor for Long-Term Survival Outcomes in Korean Men with Prostate Cancer after Radical Prostatectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorJoo Yong Lee-
dc.contributor.googleauthorDae Hun Lee-
dc.contributor.googleauthorNam Hoon Cho-
dc.contributor.googleauthorKoon Ho Rha-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorSung Joon Hong-
dc.contributor.googleauthorSeung Choul Yang-
dc.contributor.googleauthorKang Su Cho-
dc.identifier.doi10.3349/ymj.2014.55.2.316-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01227-
dc.contributor.localIdA02294-
dc.contributor.localIdA03161-
dc.contributor.localIdA03801-
dc.contributor.localIdA03812-
dc.contributor.localIdA04111-
dc.contributor.localIdA04402-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid24532498-
dc.subject.keywordProstatic neoplasms-
dc.subject.keywordcomorbidity-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameYang, Seung Choul-
dc.contributor.alternativeNameLee, Joo Yong-
dc.contributor.alternativeNameCho, Kang Su-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorYang, Seung Choul-
dc.contributor.affiliatedAuthorLee, Joo Yong-
dc.contributor.affiliatedAuthorCho, Kang Su-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.citation.volume55-
dc.citation.number2-
dc.citation.startPage316-
dc.citation.endPage323-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(2) : 316-323, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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