Cited 21 times in
Charlson Comorbidity Index Is an Important Prognostic Factor for Long-Term Survival Outcomes in Korean Men with Prostate Cancer after Radical Prostatectomy
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.contributor.author | 양승철 | - |
dc.contributor.author | 이주용 | - |
dc.contributor.author | 조강수 | - |
dc.contributor.author | 조남훈 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-01-06T16:31:57Z | - |
dc.date.available | 2015-01-06T16:31:57Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98283 | - |
dc.description.abstract | PURPOSE: To analyze overall survival (OS), prostate cancer (PCa)-specific survival (PCaSS), and non-PCaSS according to the Charlson Comorbidity Index (CCI) after radical prostatectomy (RP) for PCa. MATERIALS AND METHODS: Data from 336 patients who had RP for PCa between 1992 and 2005 were analyzed. Data included age, preoperative prostate-specific antigen (PSA), prostate volume, clinical stage, and pathologic stage. Pre-existing comorbidities were evaluated by the CCI, and patients were classified into two CCI score categories (0, ≥1). RESULTS: The mean age of patients was 64.31±6.12 years. The median PSA value (interquartile range, IQR) was 11.30 (7.35 and 21.02) ng/mL with a median follow-up period (IQR) of 96.0 (85.0 and 121.0) months. The mean CCI was 0.28 (0-4). Five-year OS, PCaSS, and non-PCaSS were 91.7%, 96.3%, and 95.2%, respectively. Ten-year OS, PCaSS, and non-PCaSS were 81.9%, 92.1%, and 88.9%, respectively. The CCI had a significant influence on OS (p=0.022) and non-PCaSS (p=0.008), but not on PCaSS (p=0.681), by log-rank test. In multivariate Cox regression analysis, OS was independently associated with the CCI [hazard ratio (HR)=1.907, p=0.025] and Gleason score (HR=2.656, p<0.001). PCaSS was independently associated with pathologic N stage (HR=2.857, p=0.031), pathologic T stage (HR=3.775, p=0.041), and Gleason score (HR=4.308, p=0.001). Non-PCaSS had a significant association only with the CCI (HR=2.540, p=0.009). CONCLUSION: The CCI was independently associated with both OS and non-PCaSS after RP, but the CCI had no impact on PCaSS. The comorbidities of a patient should be considered before selecting RP as a curative modality for PCa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 316~323 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prostatectomy/methods* | - |
dc.subject.MESH | Prostatic Neoplasms/epidemiology* | - |
dc.subject.MESH | Prostatic Neoplasms/mortality* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms/surgery* | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Survival Rate | - |
dc.title | Charlson Comorbidity Index Is an Important Prognostic Factor for Long-Term Survival Outcomes in Korean Men with Prostate Cancer after Radical Prostatectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Joo Yong Lee | - |
dc.contributor.googleauthor | Dae Hun Lee | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Seung Choul Yang | - |
dc.contributor.googleauthor | Kang Su Cho | - |
dc.identifier.doi | 10.3349/ymj.2014.55.2.316 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A02294 | - |
dc.contributor.localId | A03161 | - |
dc.contributor.localId | A03801 | - |
dc.contributor.localId | A03812 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 24532498 | - |
dc.subject.keyword | Prostatic neoplasms | - |
dc.subject.keyword | comorbidity | - |
dc.subject.keyword | survival | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Yang, Seung Choul | - |
dc.contributor.alternativeName | Lee, Joo Yong | - |
dc.contributor.alternativeName | Cho, Kang Su | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Yang, Seung Choul | - |
dc.contributor.affiliatedAuthor | Lee, Joo Yong | - |
dc.contributor.affiliatedAuthor | Cho, Kang Su | - |
dc.contributor.affiliatedAuthor | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 316 | - |
dc.citation.endPage | 323 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(2) : 316-323, 2014 | - |
dc.identifier.rimsid | 51811 | - |
dc.type.rims | ART | - |
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