Cited 37 times in
Involvement of the mirror neuron system in blunted affect in schizophrenia
DC Field | Value | Language |
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dc.contributor.author | 김재진 | - |
dc.contributor.author | 박해정 | - |
dc.date.accessioned | 2015-01-06T16:31:45Z | - |
dc.date.available | 2015-01-06T16:31:45Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0920-9964 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98277 | - |
dc.description.abstract | Blunted affect is a relatively enduring schizophrenic symptom and its presence brings about poor functioning and outcomes. Functional impairment in the mirror neuron system which is involved in both motor execution and imitation may be a neural basis of blunted affect, but it is not proved yet. Fifteen patients with schizophrenia and 16 healthy controls performed the facial expression task during functional magnetic resonance imaging. The task was to reproduce facial expressions in response to the face or word stimuli for happiness, sadness, and meaningless expression. Brain activities during facial expressions in patients compared with controls and their relationship with affective flattening were analyzed. Compared to controls, patients exhibited decreased activity in the widespread dorsal frontal regions and increased activity in the ventral frontal and subcortical regions. Patients also demonstrated significant negative correlation of the severity of affective flattening with activities in the mirror neuron system, such as the premotor cortex, motor cortex, and inferior parietal lobule. Emotional expression in patients with schizophrenia may be related to hypoactivity of the dorsal system and hyperactivity of the ventral system. An imbalance of these two systems may contribute to blunted affect. Directly addressing blunted affect using emotional expression provides a new perspective that functional disturbance of the mirror neuron system may play an important role in manifestation of blunted affect in schizophrenia. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 268~274 | - |
dc.relation.isPartOf | SCHIZOPHRENIA RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cerebral Cortex/blood supply | - |
dc.subject.MESH | Cerebral Cortex/pathology* | - |
dc.subject.MESH | Emotions/physiology* | - |
dc.subject.MESH | Facial Expression* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Processing, Computer-Assisted | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mirror Neurons/pathology* | - |
dc.subject.MESH | Neural Pathways/blood supply | - |
dc.subject.MESH | Oxygen/blood | - |
dc.subject.MESH | Pattern Recognition, Visual | - |
dc.subject.MESH | Photic Stimulation | - |
dc.subject.MESH | Psychiatric Status Rating Scales | - |
dc.subject.MESH | Schizophrenia/complications | - |
dc.subject.MESH | Schizophrenia/pathology* | - |
dc.title | Involvement of the mirror neuron system in blunted affect in schizophrenia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학) | - |
dc.contributor.googleauthor | Jung Suk Lee | - |
dc.contributor.googleauthor | Ji Won Chun | - |
dc.contributor.googleauthor | Sang Young Yoon | - |
dc.contributor.googleauthor | Hae-Jeong Park | - |
dc.contributor.googleauthor | Jae-Jin Kim | - |
dc.identifier.doi | 10.1016/j.schres.2013.10.043 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00870 | - |
dc.contributor.localId | A01730 | - |
dc.relation.journalcode | J02641 | - |
dc.identifier.eissn | 1573-2509 | - |
dc.identifier.pmid | 24268934 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0920996413005938 | - |
dc.subject.keyword | Blunted affect | - |
dc.subject.keyword | Facial expressions | - |
dc.subject.keyword | Mirror neuron system | - |
dc.subject.keyword | Schizophrenia | - |
dc.subject.keyword | fMRI | - |
dc.contributor.alternativeName | Kim, Jae Jin | - |
dc.contributor.alternativeName | Park, Hae Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Jae Jin | - |
dc.contributor.affiliatedAuthor | Park, Hae Jeong | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 152 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 268 | - |
dc.citation.endPage | 274 | - |
dc.identifier.bibliographicCitation | SCHIZOPHRENIA RESEARCH, Vol.152(1) : 268-274, 2014 | - |
dc.identifier.rimsid | 51809 | - |
dc.type.rims | ART | - |
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