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Involvement of the mirror neuron system in blunted affect in schizophrenia

DC FieldValueLanguage
dc.contributor.author김재진-
dc.contributor.author박해정-
dc.date.accessioned2015-01-06T16:31:45Z-
dc.date.available2015-01-06T16:31:45Z-
dc.date.issued2014-
dc.identifier.issn0920-9964-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98277-
dc.description.abstractBlunted affect is a relatively enduring schizophrenic symptom and its presence brings about poor functioning and outcomes. Functional impairment in the mirror neuron system which is involved in both motor execution and imitation may be a neural basis of blunted affect, but it is not proved yet. Fifteen patients with schizophrenia and 16 healthy controls performed the facial expression task during functional magnetic resonance imaging. The task was to reproduce facial expressions in response to the face or word stimuli for happiness, sadness, and meaningless expression. Brain activities during facial expressions in patients compared with controls and their relationship with affective flattening were analyzed. Compared to controls, patients exhibited decreased activity in the widespread dorsal frontal regions and increased activity in the ventral frontal and subcortical regions. Patients also demonstrated significant negative correlation of the severity of affective flattening with activities in the mirror neuron system, such as the premotor cortex, motor cortex, and inferior parietal lobule. Emotional expression in patients with schizophrenia may be related to hypoactivity of the dorsal system and hyperactivity of the ventral system. An imbalance of these two systems may contribute to blunted affect. Directly addressing blunted affect using emotional expression provides a new perspective that functional disturbance of the mirror neuron system may play an important role in manifestation of blunted affect in schizophrenia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent268~274-
dc.relation.isPartOfSCHIZOPHRENIA RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCerebral Cortex/blood supply-
dc.subject.MESHCerebral Cortex/pathology*-
dc.subject.MESHEmotions/physiology*-
dc.subject.MESHFacial Expression*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImage Processing, Computer-Assisted-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMirror Neurons/pathology*-
dc.subject.MESHNeural Pathways/blood supply-
dc.subject.MESHOxygen/blood-
dc.subject.MESHPattern Recognition, Visual-
dc.subject.MESHPhotic Stimulation-
dc.subject.MESHPsychiatric Status Rating Scales-
dc.subject.MESHSchizophrenia/complications-
dc.subject.MESHSchizophrenia/pathology*-
dc.titleInvolvement of the mirror neuron system in blunted affect in schizophrenia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학)-
dc.contributor.googleauthorJung Suk Lee-
dc.contributor.googleauthorJi Won Chun-
dc.contributor.googleauthorSang Young Yoon-
dc.contributor.googleauthorHae-Jeong Park-
dc.contributor.googleauthorJae-Jin Kim-
dc.identifier.doi10.1016/j.schres.2013.10.043-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00870-
dc.contributor.localIdA01730-
dc.relation.journalcodeJ02641-
dc.identifier.eissn1573-2509-
dc.identifier.pmid24268934-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0920996413005938-
dc.subject.keywordBlunted affect-
dc.subject.keywordFacial expressions-
dc.subject.keywordMirror neuron system-
dc.subject.keywordSchizophrenia-
dc.subject.keywordfMRI-
dc.contributor.alternativeNameKim, Jae Jin-
dc.contributor.alternativeNamePark, Hae Jeong-
dc.contributor.affiliatedAuthorKim, Jae Jin-
dc.contributor.affiliatedAuthorPark, Hae Jeong-
dc.rights.accessRightsfree-
dc.citation.volume152-
dc.citation.number1-
dc.citation.startPage268-
dc.citation.endPage274-
dc.identifier.bibliographicCitationSCHIZOPHRENIA RESEARCH, Vol.152(1) : 268-274, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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