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Anatomic extent of metastatic lymph nodes: Still important for gastric cancer prognosis

DC FieldValueLanguage
dc.contributor.author김종원-
dc.contributor.author김형일-
dc.contributor.author노성훈-
dc.contributor.author손태일-
dc.contributor.author안지영-
dc.contributor.author정재호-
dc.contributor.author최승호-
dc.contributor.author형우진-
dc.date.accessioned2015-01-06T16:30:56Z-
dc.date.available2015-01-06T16:30:56Z-
dc.date.issued2014-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98251-
dc.description.abstractBACKGROUND: Currently, gastric cancer staging systems do not consider the anatomic extent of metastatic lymph nodes (mLNs) as a prognostic factor. We therefore investigated the prognostic impact of the anatomic extent of mLNs on gastric cancer. METHODS: The prognoses of 4,043 gastric cancer patients who underwent curative resection were analyzed. Patients with mLNs in lymph node (LN) stations 1-6 (n = 1,980) comprised the perigastric LN-positive (PLN) group, and patients with mLNs in LN stations 7-12 and 14 (n = 2,063) were assigned to the extraperigastric LN-positive (ELN) group. Overall survival was estimated using the Kaplan-Meier method, and hazard ratios (HRs) were calculated by the Cox proportional hazard model. RESULTS: The ELN group exhibited worse survival than the PLN group (p < 0.001), although there were differences in their clinicopathological features. When patients were stratified according to tumor-node-metastasis stage, the ELN groups had unfavorable prognoses compared with the PLN groups (p < 0.05). There were significant differences in long-term survival when the nodal stage of the current staging systems were subdivided according to anatomic nodal extent (p < 0.05), although there was a strong association between the probability of having extraperigastric mLNs and N classification. In multivariate analysis using age, gender, tumor size, tumor location, histology, T classification, and the extent of mLNs as covariates, presence of extraperigastric mLNs was an independent prognostic factor (HR 1.89, 95 % CI 1.73-2.07), along with age, tumor size, tumor location, and T classification. CONCLUSIONS: The anatomic extent of mLNs significantly affects patient prognosis. Including the anatomic extent of mLNs in the current staging system may predict gastric cancer prognosis more accurately in patients with the same stage of cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent899~907-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/mortality-
dc.subject.MESHAdenocarcinoma/secondary*-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy*-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPostoperative Complications-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHStomach Neoplasms/mortality-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery-
dc.subject.MESHSurvival Rate-
dc.subject.MESHYoung Adult-
dc.titleAnatomic extent of metastatic lymph nodes: Still important for gastric cancer prognosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorTaeil Son-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorHyoung-Il Kim-
dc.contributor.googleauthorJi Yeong An-
dc.contributor.googleauthorJae-Ho Cheong-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSung Hoon Noh-
dc.identifier.doi10.1245/s10434-013-3403-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04102-
dc.contributor.localIdA00925-
dc.contributor.localIdA01154-
dc.contributor.localIdA01281-
dc.contributor.localIdA01998-
dc.contributor.localIdA03717-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid24276641-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-013-3403-x-
dc.subject.keywordGastric Cancer-
dc.subject.keywordOverall Survival-
dc.subject.keywordGastric Cancer Patient-
dc.subject.keywordJapanese Gastric Cancer Association-
dc.subject.keywordNodal Classification-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNameKim, Hyoung Il-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameSon, Tae Il-
dc.contributor.alternativeNameAn, Ji Yeong-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.contributor.affiliatedAuthorKim, Hyoung Il-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorSon, Tae Il-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number3-
dc.citation.startPage899-
dc.citation.endPage907-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.21(3) : 899-907, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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