Cited 17 times in
The Relationship of Initial Transferrin Saturation to Cardiovascular Parameters and Outcomes in Patients Initiating Dialysis
DC Field | Value | Language |
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dc.contributor.author | 김은진 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 김찬호 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 한재현 | - |
dc.contributor.author | 한지숙 | - |
dc.date.accessioned | 2015-01-06T16:30:12Z | - |
dc.date.available | 2015-01-06T16:30:12Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98227 | - |
dc.description.abstract | BACKGROUND: The prognostic importance of anemia for cardiovascular (CV) events and mortality has been extensively investigated. However, little is known about the impact of transferrin saturation (TSAT), a marker reflecting the availability of iron for erythropoiesis, on clinical outcome in dialysis patients. METHODS: A total of 879 anemic incident dialysis patients were recruited from the Clinical Research Center for End-Stage Renal Disease in Korea and were divided into 3 groups according to baseline TSAT of ≤20%, 20-40%, and >40%. RESULTS: There were no differences in hemoglobin levels and the proportion of patients on erythropoiesis-stimulating agents or iron supplements among the 3 groups. During a mean follow-up duration of 19.3 months, 51 (5.8%) patients died. CV composite (11.71 vs. 5.55 events/100 patient-years, P = 0.001) and all-cause mortality rates (5.38 vs. 2.31 events/100 patient-years, P = 0.016) were significantly higher in patients with TSAT ≤20% compared to those with TSAT 20-40% (reference group). Cox regression analysis revealed that patients with TSAT ≤20% had 1.62- and 2.19-fold higher risks for CV composite outcome (P = 0.046) and all-cause mortality (P = 0.030). Moreover, TSAT ≤20% was significantly associated with left ventricular hypertrophy [odds ratio (OR) = 1.46], high-sensitivity C-reactive protein ≥3 mg/dL (OR = 2.09), N-terminal pro B-type natriuretic peptide ≥10000 pg/mL (OR = 2.04), and troponin-T≥0.1 ng/mL (OR = 2.02), on logistic regression analysis. CONCLUSIONS: Low TSAT was a significant independent risk factor for adverse clinical outcome in incident dialysis patients with anemia, which may be partly attributed to cardiac dysfunction and inflammation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | e87231 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anemia*/blood | - |
dc.subject.MESH | Anemia*/etiology | - |
dc.subject.MESH | Anemia*/mortality | - |
dc.subject.MESH | Anemia*/therapy | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic*/blood | - |
dc.subject.MESH | Kidney Failure, Chronic*/mortality | - |
dc.subject.MESH | Kidney Failure, Chronic*/therapy | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Renal Dialysis* | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Transferrin/metabolism* | - |
dc.title | The Relationship of Initial Transferrin Saturation to Cardiovascular Parameters and Outcomes in Patients Initiating Dialysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Eun Jin Kim | - |
dc.contributor.googleauthor | Jae Hyun Han | - |
dc.contributor.googleauthor | Ji Suk Han | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.identifier.doi | 10.1371/journal.pone.0087231 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A04320 | - |
dc.contributor.localId | A04327 | - |
dc.contributor.localId | A00823 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 24505281 | - |
dc.contributor.alternativeName | Kim, Eun Jin | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Han, Jae Hyun | - |
dc.contributor.alternativeName | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Han, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Hahn, Jee Sook | - |
dc.contributor.affiliatedAuthor | Kim, Eun Jin | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | e87231 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.9(2) : e87231, 2014 | - |
dc.identifier.rimsid | 50731 | - |
dc.type.rims | ART | - |
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