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The Relationship of Initial Transferrin Saturation to Cardiovascular Parameters and Outcomes in Patients Initiating Dialysis

DC FieldValueLanguage
dc.contributor.author김은진-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author김찬호-
dc.contributor.author도화미-
dc.contributor.author박정탁-
dc.contributor.author강신욱-
dc.contributor.author구향모-
dc.contributor.author이미정-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author한지숙-
dc.date.accessioned2015-01-06T16:30:12Z-
dc.date.available2015-01-06T16:30:12Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98227-
dc.description.abstractBACKGROUND: The prognostic importance of anemia for cardiovascular (CV) events and mortality has been extensively investigated. However, little is known about the impact of transferrin saturation (TSAT), a marker reflecting the availability of iron for erythropoiesis, on clinical outcome in dialysis patients. METHODS: A total of 879 anemic incident dialysis patients were recruited from the Clinical Research Center for End-Stage Renal Disease in Korea and were divided into 3 groups according to baseline TSAT of ≤20%, 20-40%, and >40%. RESULTS: There were no differences in hemoglobin levels and the proportion of patients on erythropoiesis-stimulating agents or iron supplements among the 3 groups. During a mean follow-up duration of 19.3 months, 51 (5.8%) patients died. CV composite (11.71 vs. 5.55 events/100 patient-years, P = 0.001) and all-cause mortality rates (5.38 vs. 2.31 events/100 patient-years, P = 0.016) were significantly higher in patients with TSAT ≤20% compared to those with TSAT 20-40% (reference group). Cox regression analysis revealed that patients with TSAT ≤20% had 1.62- and 2.19-fold higher risks for CV composite outcome (P = 0.046) and all-cause mortality (P = 0.030). Moreover, TSAT ≤20% was significantly associated with left ventricular hypertrophy [odds ratio (OR)  = 1.46], high-sensitivity C-reactive protein ≥3 mg/dL (OR = 2.09), N-terminal pro B-type natriuretic peptide ≥10000 pg/mL (OR  = 2.04), and troponin-T≥0.1 ng/mL (OR  = 2.02), on logistic regression analysis. CONCLUSIONS: Low TSAT was a significant independent risk factor for adverse clinical outcome in incident dialysis patients with anemia, which may be partly attributed to cardiac dysfunction and inflammation.-
dc.description.statementOfResponsibilityopen-
dc.format.extente87231-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnemia*/blood-
dc.subject.MESHAnemia*/etiology-
dc.subject.MESHAnemia*/mortality-
dc.subject.MESHAnemia*/therapy-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Failure, Chronic*/blood-
dc.subject.MESHKidney Failure, Chronic*/mortality-
dc.subject.MESHKidney Failure, Chronic*/therapy-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRenal Dialysis*-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTransferrin/metabolism*-
dc.titleThe Relationship of Initial Transferrin Saturation to Cardiovascular Parameters and Outcomes in Patients Initiating Dialysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorJi Suk Han-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1371/journal.pone.0087231-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA01037-
dc.contributor.localIdA01315-
dc.contributor.localIdA01654-
dc.contributor.localIdA00053-
dc.contributor.localIdA00203-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA04327-
dc.contributor.localIdA00823-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid24505281-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameHahn, Jee Sook-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorHahn, Jee Sook-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.citation.volume9-
dc.citation.number2-
dc.citation.startPagee87231-
dc.identifier.bibliographicCitationPLOS ONE, Vol.9(2) : e87231, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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