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Oncologic Safety of Pylorus-preserving Gastrectomy in the Aspect of Micrometastasis in Lymph Nodes at Stations 5 and 6

DC Field Value Language
dc.contributor.author김종원-
dc.contributor.author윤선옥-
dc.contributor.author최승호-
dc.contributor.author홍순원-
dc.date.accessioned2015-01-06T16:29:44Z-
dc.date.available2015-01-06T16:29:44Z-
dc.date.issued2014-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98212-
dc.description.abstractBACKGROUND: Pylorus-preserving gastrectomy (PPG) is a function-preserving gastrectomy for early gastric cancers (EGCs) that are preoperatively assessed as pN0 tumors and located in the middle portion of the stomach. In PPG, dissection of the lymph nodes at stations 5 and 6 is frequently incomplete, and this may be worrisome in terms of oncologic safety. METHODS: We examined lymph nodes collected from stations 5 and 6 from 196 patients who had undergone conventional distal gastrectomy (CDG) for EGC located in the middle portion of the stomach and from 24 patients who had undergone PPG. RESULTS: The average number of lymph nodes collected at station 5 was significantly lower with PPG than with CDG (0.08 vs. 1.32, respectively; P = 0.008). However, such a difference was not noted for station 6 nodes. The rate of macrometastasis was very low in all station 5 nodes (1 of 220, 0.45%) and station 6 nodes (1 of 220, 0.45%). Immunohistochemical analysis of cytokeratin in 109 cases of the CDG group and 21 cases of the PPG group showed that micrometastasis of single isolated tumor cell type was observed in only one station 6 lymph node of a patient who was initially diagnosed with pN0 EGC. There were no cases of micrometastasis in station 5 nodes. CONCLUSIONS: The possibility of micrometastasis to station 5 and/or 6 lymph nodes may be negligible for EGC located in the middle portion of the stomach, and PPG thus might be the oncologically safe procedure when considering micrometastasis in remaining nodes in vivo at stations 5 and 6-
dc.description.statementOfResponsibilityopen-
dc.format.extent533~538-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAdenocarcinoma/surgery*-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy*-
dc.subject.MESHHumans-
dc.subject.MESHImmunoenzyme Techniques-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHLymph Nodes/metabolism-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymph Nodes/surgery*-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHNeoplasm Micrometastasis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHOrgan Sparing Treatments*-
dc.subject.MESHPrognosis-
dc.subject.MESHPylorus/metabolism-
dc.subject.MESHPylorus/pathology-
dc.subject.MESHPylorus/surgery*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHStomach Neoplasms/pathology-
dc.subject.MESHStomach Neoplasms/surgery*-
dc.titleOncologic Safety of Pylorus-preserving Gastrectomy in the Aspect of Micrometastasis in Lymph Nodes at Stations 5 and 6-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorBaek-hui Kim-
dc.contributor.googleauthorSoon Won Hong-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorSun Och Yoon-
dc.identifier.doi10.1245/s10434-013-3252-7-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA04102-
dc.contributor.localIdA00925-
dc.contributor.localIdA02566-
dc.contributor.localIdA04411-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid24008556-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-013-3252-7-
dc.subject.keywordLymph Node-
dc.subject.keywordEarly Gastric Cancer-
dc.subject.keywordMetastatic Lymph Node-
dc.subject.keywordMiddle Portion-
dc.subject.keywordIsolate Tumor Cell-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameHong, Soon Won-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorHong, Soon Won-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number2-
dc.citation.startPage533-
dc.citation.endPage538-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.21(2) : 533-538, 2014-
dc.identifier.rimsid50720-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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