Cited 4 times in
Prevalence and Management of Lower Urinary Tract Symptoms in Methamphetamine Abusers: An Under-Recognized Clinical Identity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구교철 | - |
dc.contributor.author | 김장환 | - |
dc.contributor.author | 나군호 | - |
dc.contributor.author | 마상열 | - |
dc.contributor.author | 이동훈 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 홍성준 | - |
dc.date.accessioned | 2015-01-06T16:28:51Z | - |
dc.date.available | 2015-01-06T16:28:51Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98184 | - |
dc.description.abstract | PURPOSE: We investigate the prevalence of lower urinary tract symptoms in a cohort of methamphetamine abusers, and assess the therapeutic efficacy of α-blockers and anticholinergics. MATERIALS AND METHODS: From May 2011 to March 2013, 78 male methamphetamine abusers diagnosed with methamphetamine addiction were identified at the National Forensic Hospital, Korea. The I-PSS (International Prostate Symptom Score) with consultation was used to investigate the prevalence of lower urinary tract symptoms, defined as total I-PSS 8 or greater and quality of life index score of 2 or greater. These values for methamphetamine abusers were compared to those of 71 age matched controls. α-Blockers and anticholinergics were administered to methamphetamine abusers with lower urinary tract symptoms according to predominant voiding and storage symptoms based on voiding-to-storage subscore ratios. For methamphetamine abusers with no response, defined as a reduction of 4 or less in total I-PSS, an alternative drug or combination was administered. Efficacy was assessed based on a 4-week interval. RESULTS: The median periods of methamphetamine abuse and abstinence were 18.1 years and 5.7 months, respectively. Methamphetamine abusers showed a higher prevalence of lower urinary tract symptoms compared to controls (77% vs 15%, p <0.001), with higher I-PSS and quality of life index score (13.3 vs 5.6 and 2.9 vs 0.9, respectively; p <0.001). Anticholinergics showed the greatest effect on I-PSS reduction with overall response rates for α-blockers, anticholinergics and combinations of 13%, 61% and 14%, respectively. Seven (12%) methamphetamine abusers did not respond to any therapy. CONCLUSIONS: Lower urinary tract symptoms were highly prevalent among methamphetamine abusers. Our results imply that pathological dopaminergic mechanisms have a role in methamphetamine associated lower urinary tract symptoms. Moreover, first line anticholinergics and prompt combination with α-blockers conferred the most therapeutic benefit to nonresponders. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 722~726 | - |
dc.relation.isPartOf | JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic alpha-Antagonists/therapeutic use* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cholinergic Antagonists/therapeutic use* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lower Urinary Tract Symptoms/chemically induced* | - |
dc.subject.MESH | Lower Urinary Tract Symptoms/drug therapy* | - |
dc.subject.MESH | Lower Urinary Tract Symptoms/epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methamphetamine/toxicity* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Substance-Related Disorders/complications* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Prevalence and Management of Lower Urinary Tract Symptoms in Methamphetamine Abusers: An Under-Recognized Clinical Identity | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Dong Hoon Lee | - |
dc.contributor.googleauthor | Jang Hwan Kim | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Sang Yol Mah | - |
dc.identifier.doi | 10.1016/j.juro.2013.08.020 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02742 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A00855 | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A01344 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A04402 | - |
dc.relation.journalcode | J01921 | - |
dc.identifier.eissn | 1527-3792 | - |
dc.identifier.pmid | 23968967 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0022534713051409 | - |
dc.subject.keyword | lower urinary tract symptoms | - |
dc.subject.keyword | methamphetamine | - |
dc.subject.keyword | prevalence | - |
dc.subject.keyword | treatment outcome | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.alternativeName | Kim, Jang Hwan | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Mah, Sang Yol | - |
dc.contributor.alternativeName | Lee, Dong Hoon | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Lee, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Kim, Jang Hwan | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Mah, Sang Yol | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 191 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 722 | - |
dc.citation.endPage | 726 | - |
dc.identifier.bibliographicCitation | JOURNAL OF UROLOGY, Vol.191(3) : 722-726, 2014 | - |
dc.identifier.rimsid | 50702 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.