Cited 15 times in
Prognostic implications of anaplastic lymphoma kinase gene aberrations in rhabdomyosarcoma; an immunohistochemical and fluorescence in situ hybridisation study
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 노재경 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 신규호 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 이재석 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 조영진 | - |
dc.date.accessioned | 2015-01-06T16:28:28Z | - |
dc.date.available | 2015-01-06T16:28:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98172 | - |
dc.description.abstract | BACKGROUND: We investigated the diagnostic and prognostic usefulness of anaplastic lymphoma kinase (ALK) expression in Asian rhabdomyosarcoma (RMS) patients. PATIENTS AND METHODS: A total of 38 RMS tissue samples were collected over a 14-year period (1998-2012). ALK protein expression and gene copy number were analysed by immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH). RESULTS: Ten of the 38 RMS patients (26.3%) showed positive ALK protein expression. ALK protein expression was predominantly positive in alveolar RMS (ARMS) compared with embryonal RMS (ERMS) (80% vs 20%, p=0.03). ALK protein expression was statistically associated with ARMS histology, metastatic disease at diagnosis, and primary trunk site. In FISH analysis, no translocations were detected and ALK gene copy number gain was observed more frequently in ARMS than in ERMS (40% vs 17%). The ALK-positive group showed inferior overall survival (OS) compared with ALK-negative group (p=0.014) for both alveolar and embryonal RMS patients. In multivariate analysis, positive ALK expression was an independent prognostic factor for OS (p=0.02; HR, 3.1; 95% CI 1.2 to 8.3). There was a significant strong positive correlation between ALK gene copy number and protein expression (Spearman's r<0.001, r=0.77). CONCLUSIONS: We demonstrated that ALK protein expression is statistically associated with ARMS histology, metastatic disease at diagnosis and primary trunk site. Additionally, ALK expression was an independent prognostic factor for worse survival. There was a strong correlation between IHC and FISH. Further studies are needed to evaluate the potential diagnostic and therapeutic role of ALK expression in RMS. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 33~39 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor/analysis* | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Dosage | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Receptor Protein-Tyrosine Kinases/genetics* | - |
dc.subject.MESH | Receptor Protein-Tyrosine Kinases/metabolism | - |
dc.subject.MESH | Rhabdomyosarcoma/genetics* | - |
dc.subject.MESH | Rhabdomyosarcoma/mortality* | - |
dc.subject.MESH | Rhabdomyosarcoma/pathology | - |
dc.subject.MESH | Young Adult | - |
dc.title | Prognostic implications of anaplastic lymphoma kinase gene aberrations in rhabdomyosarcoma; an immunohistochemical and fluorescence in situ hybridisation study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | Jae Seok Lee | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.contributor.googleauthor | Jae Kyung Roh | - |
dc.contributor.googleauthor | Yong Jin Cho | - |
dc.contributor.googleauthor | Kyu Ho Shin | - |
dc.contributor.googleauthor | Woo Ik Yang | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.identifier.doi | 10.1136/jclinpath-2013-201655 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A02086 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A03860 | - |
dc.contributor.localId | A03072 | - |
dc.contributor.localId | A01316 | - |
dc.relation.journalcode | J01334 | - |
dc.identifier.eissn | 1472-4146 | - |
dc.identifier.pmid | 23922356 | - |
dc.identifier.url | http://jcp.bmj.com/content/67/1/33.long | - |
dc.subject.keyword | FISH | - |
dc.subject.keyword | IMMUNOCYTOCHEMISTRY | - |
dc.subject.keyword | rhabdomyosarcoma | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Shin, Kyoo Ho | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Lee, Jae Seok | - |
dc.contributor.alternativeName | Lim, Sun Min | - |
dc.contributor.alternativeName | Cho, Yong Jin | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | Shin, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Lim, Sun Min | - |
dc.contributor.affiliatedAuthor | Cho, Yong Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jae Seok | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 67 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.endPage | 39 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PATHOLOGY, Vol.67(1) : 33-39, 2014 | - |
dc.identifier.rimsid | 50695 | - |
dc.type.rims | ART | - |
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