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The RON Receptor Tyrosine Kinase in Pancreatic Cancer Pathogenesis and Its Potential Implications for Future Targeted Therapies

DC Field Value Language
dc.contributor.author강창무-
dc.date.accessioned2015-01-06T16:26:43Z-
dc.date.available2015-01-06T16:26:43Z-
dc.date.issued2014-
dc.identifier.issn0885-3177-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98118-
dc.description.abstractPancreatic cancer remains a devastating disease with a mortality rate that has not changed substantially in decades. Novel therapies are therefore desperately needed. The RON receptor tyrosine kinase has been identified as an important mediator of KRAS oncogene addiction and is overexpressed in the majority of pancreatic cancers. Preclinical studies show that inhibition of RON function decreases pancreatic cancer cell migration, invasion, and survival and can sensitize pancreatic cancer cells to chemotherapy. This article reviews the current state of knowledge regarding RON biology and pancreatic cancer and discusses its potential as a therapeutic target.-
dc.description.statementOfResponsibilityopen-
dc.format.extent183~189-
dc.relation.isPartOfPANCREAS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAntibodies, Monoclonal/therapeutic use*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement/drug effects-
dc.subject.MESHCell Proliferation/drug effects-
dc.subject.MESHForecasting-
dc.subject.MESHHumans-
dc.subject.MESHMolecular Targeted Therapy/methods*-
dc.subject.MESHMolecular Targeted Therapy/trends-
dc.subject.MESHPancreatic Neoplasms/drug therapy*-
dc.subject.MESHPancreatic Neoplasms/metabolism-
dc.subject.MESHPancreatic Neoplasms/pathology-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/antagonists & inhibitors*-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/immunology-
dc.subject.MESHReceptor Protein-Tyrosine Kinases/metabolism-
dc.subject.MESHSignal Transduction/drug effects-
dc.titleThe RON Receptor Tyrosine Kinase in Pancreatic Cancer Pathogenesis and Its Potential Implications for Future Targeted Therapies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorMichele L. Babicky-
dc.contributor.googleauthorAndrew M. Lowy-
dc.identifier.doi10.1097/MPA.0000000000000088-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00088-
dc.relation.journalcodeJ02463-
dc.identifier.eissn1536-4828-
dc.identifier.pmid24518495-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201403000-00003&LSLINK=80&D=ovft-
dc.subject.keywordpancreatic cancer-
dc.subject.keywordRON receptor-
dc.subject.keywordtyrosine kinase-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.rights.accessRightsfree-
dc.citation.volume43-
dc.citation.number2-
dc.citation.startPage183-
dc.citation.endPage189-
dc.identifier.bibliographicCitationPANCREAS, Vol.43(2) : 183-189, 2014-
dc.identifier.rimsid54899-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
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