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Cited 21 times in

Clinical implication of crescentic lesions in immunoglobulin A nephropathy

DC FieldValueLanguage
dc.contributor.author고광일-
dc.contributor.author구향모-
dc.contributor.author김승준-
dc.contributor.author김찬호-
dc.contributor.author도화미-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author임범진-
dc.contributor.author정현주-
dc.contributor.author최규헌-
dc.contributor.author한승혁-
dc.contributor.author강신욱-
dc.date.accessioned2015-01-06T16:26:07Z-
dc.date.available2015-01-06T16:26:07Z-
dc.date.issued2014-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98099-
dc.description.abstractBACKGROUND: To date, there has been much controversy about the role of crescentic lesion as a significant prognostic factor in immunoglobulin A nephropathy (IgAN). This study evaluated whether crescentic lesions predict adverse renal outcomes in IgAN patients. METHODS: A total of 430 patients with biopsy-proven IgAN between January 2000 and December 2009 were included. Histological variables of the Oxford classification (Oxford-MEST) and the presence of crescents were assessed. The primary endpoint was a 50% decline in estimated glomerular filtration rate. RESULTS: Of the 430 patients, 81 (18.8%) had a crescentic lesion. During a mean follow-up of 61 months, the primary outcome occurred in 19 (23.5%) patients with crescents compared with 40 (11.5%) patients without crescents (P=0.01). A Kaplan-Meier plot showed that the 10-year renal survival rate was significantly lower in patients with crescents than patients without crescents (P=0.01). However, in a multivariable Cox analysis which included clinical factors and the Oxford-MEST, crescents were not significantly associated with an increased risk of developing the primary outcome [hazard ratio: 0.71, 95% confidence interval (CI) 0.36-1.41, P=0.33]. Furthermore, adding crescents to the Oxford-MEST did not improve the discriminative ability for the prediction of renal outcomes [c-statistic: 0.86 (0.81-0.91) vs. 0.86 (0.80-0.91), P=0.21]. CONCLUSION: Crescentic lesion was not an independent prognostic factor, suggesting that crescents have limited value in predicting renal outcomes of IgAN.-
dc.description.statementOfResponsibilityopen-
dc.format.extent356~364-
dc.relation.isPartOfNephrology Dialysis Transplantation-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleClinical implication of crescentic lesions in immunoglobulin A nephropathy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorSeung Jun Kim-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorKwang Il Ko-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorKyu Hun Choi-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1093/ndt/gft398-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00110-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01315-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA03363-
dc.contributor.localIdA03771-
dc.contributor.localIdA04043-
dc.contributor.localIdA04304-
dc.contributor.localIdA00053-
dc.contributor.localIdA00659-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02316-
dc.identifier.urlhttp://ndt.oxfordjournals.org/content/29/2/356.long-
dc.contributor.alternativeNameKo, Kwang Il-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Seung Jun-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameChoi, Kyu Hun-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthorKo, Kwang Il-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorChoi, Kyu Hun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Seung Jun-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsfree-
dc.citation.volume29-
dc.citation.number2-
dc.citation.startPage356-
dc.citation.endPage364-
dc.identifier.bibliographicCitationNephrology Dialysis Transplantation, Vol.29(2) : 356-364, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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