Cited 32 times in
Clinical implication of crescentic lesions in immunoglobulin A nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고광일 | - |
dc.contributor.author | 구향모 | - |
dc.contributor.author | 김승준 | - |
dc.contributor.author | 김찬호 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 임범진 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 최규헌 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강신욱 | - |
dc.date.accessioned | 2015-01-06T16:26:07Z | - |
dc.date.available | 2015-01-06T16:26:07Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/98099 | - |
dc.description.abstract | BACKGROUND: To date, there has been much controversy about the role of crescentic lesion as a significant prognostic factor in immunoglobulin A nephropathy (IgAN). This study evaluated whether crescentic lesions predict adverse renal outcomes in IgAN patients. METHODS: A total of 430 patients with biopsy-proven IgAN between January 2000 and December 2009 were included. Histological variables of the Oxford classification (Oxford-MEST) and the presence of crescents were assessed. The primary endpoint was a 50% decline in estimated glomerular filtration rate. RESULTS: Of the 430 patients, 81 (18.8%) had a crescentic lesion. During a mean follow-up of 61 months, the primary outcome occurred in 19 (23.5%) patients with crescents compared with 40 (11.5%) patients without crescents (P=0.01). A Kaplan-Meier plot showed that the 10-year renal survival rate was significantly lower in patients with crescents than patients without crescents (P=0.01). However, in a multivariable Cox analysis which included clinical factors and the Oxford-MEST, crescents were not significantly associated with an increased risk of developing the primary outcome [hazard ratio: 0.71, 95% confidence interval (CI) 0.36-1.41, P=0.33]. Furthermore, adding crescents to the Oxford-MEST did not improve the discriminative ability for the prediction of renal outcomes [c-statistic: 0.86 (0.81-0.91) vs. 0.86 (0.80-0.91), P=0.21]. CONCLUSION: Crescentic lesion was not an independent prognostic factor, suggesting that crescents have limited value in predicting renal outcomes of IgAN. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 356~364 | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glomerular Filtration Rate* | - |
dc.subject.MESH | Glomerulonephritis, IGA/complications | - |
dc.subject.MESH | Glomerulonephritis, IGA/pathology* | - |
dc.subject.MESH | Glomerulonephritis, IGA/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Kidney/pathology* | - |
dc.subject.MESH | Kidney/physiopathology | - |
dc.subject.MESH | Kidney Failure, Chronic/epidemiology | - |
dc.subject.MESH | Kidney Failure, Chronic/etiology | - |
dc.subject.MESH | Kidney Failure, Chronic/pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Clinical implication of crescentic lesions in immunoglobulin A nephropathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Seung Jun Kim | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Kwang Il Ko | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Kyu Hun Choi | - |
dc.contributor.googleauthor | Beom Jin Lim | - |
dc.contributor.googleauthor | Hyeon Joo Jeong | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1093/ndt/gft398 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00110 | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03363 | - |
dc.contributor.localId | A03771 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00659 | - |
dc.contributor.localId | A02773 | - |
dc.relation.journalcode | J02316 | - |
dc.identifier.eissn | 1460-2385 | - |
dc.identifier.pmid | 24081867 | - |
dc.identifier.url | http://ndt.oxfordjournals.org/content/29/2/356.long | - |
dc.subject.keyword | Oxford classification | - |
dc.subject.keyword | crescents | - |
dc.subject.keyword | immunoglobulin a nephropathy | - |
dc.subject.keyword | outcome | - |
dc.contributor.alternativeName | Ko, Kwang Il | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Seung Jun | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Lim, Beom Jin | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Ko, Kwang Il | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Lim, Beom Jin | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon Joo | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Kim, Seung Jun | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 356 | - |
dc.citation.endPage | 364 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.29(2) : 356-364, 2014 | - |
dc.identifier.rimsid | 54888 | - |
dc.type.rims | ART | - |
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