4 632

Cited 38 times in

Postoperative levonorgestrel-releasing intrauterine system versus oral contraceptives after gonadotropin-releasing hormone agonist treatment for preventing endometrioma recurrence

DC Field Value Language
dc.contributor.author김혜연-
dc.contributor.author서석교-
dc.contributor.author이병석-
dc.contributor.author정지안-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2015-01-06T16:26:04Z-
dc.date.available2015-01-06T16:26:04Z-
dc.date.issued2014-
dc.identifier.issn0001-6349-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/98098-
dc.description.abstractOBJECTIVE: Although the levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in reducing the recurrence of endometriosis-associated pain, its efficacy in preventing endometrioma recurrence is questionable. We compared the efficacy of postoperative use of LNG-IUS with oral contraceptives (OC) for preventing endometrioma recurrence. DESIGN: A retrospective cohort study. SETTING: Medical university hospital. POPULATION: Ninety-nine women with endometriomas. METHODS: A chart review was performed of women of reproductive age who had undergone laparoscopic surgery for endometrioma followed by three cycles of gonadotropin-releasing hormone agonist (leuprolide acetate) treatment. Women were categorized into two groups: a group that had postoperative LNG-IUS placement (n = 42) and a group that received postoperative, cyclic, low-dose, monophasic, OCs (n = 57). Main outcome measures. Endometrioma recurrence was analyzed according to several clinical variables and postoperative treatment modalities. RESULTS: During the follow-up period (median 17 months), recurrent endometriomas were detected in eight women (8.1%). Patients with LNG-IUS had a recurrence rate of 4.8% (2/42), whereas women receiving OC had a recurrence rate of 10.5% (6/57). Cumulative recurrence-free survival assessment revealed that mean disease-free survival times for both groups were similar, but that for LNG-IUS was slightly longer than that for OC, with statistical significance (34.4 ± 1.0 months, 95% confidence interval 32.3–36.5, vs. 33.4 ± 1.3 months, 95% confidence interval 30.8–36.0, p = 0.045). Univariate analysis revealed a hazard ratio of 0.178 (95% confidence interval 0.029–1.075) (p = 0.060) for postoperative LNG-IUS use and endometrioma recurrence. However, for the multivariate regression analysis, only postoperative serum CA 125 levels were significantly associated with endometrioma recurrence (hazard ratio 1.012, p = 0.010).CONCLUSIONS: Postoperative LNG-IUS use seemed to be comparable to the use of cyclic OC in preventing endometrioma recurrence.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePostoperative levonorgestrel-releasing intrauterine system versus oral contraceptives after gonadotropin-releasing hormone agonist treatment for preventing endometrioma recurrence-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics & Gynecology (산부인과학)-
dc.contributor.googleauthorSihyun Cho-
dc.contributor.googleauthorJi Ann Jung-
dc.contributor.googleauthorYousun Lee-
dc.contributor.googleauthorHye Yeon Kim-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorJi Sung Lee-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi10.1111/aogs.12294-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01174-
dc.contributor.localIdA01888-
dc.contributor.localIdA02795-
dc.contributor.localIdA03733-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ00022-
dc.identifier.eissn1600-0412-
dc.identifier.pmid24843434-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aogs.12294/abstract-
dc.subject.keywordEdema-
dc.subject.keywordPioglitazone-
dc.contributor.alternativeNameKim, Hye Yeon-
dc.contributor.alternativeNameSeo, Seok Kyo-
dc.contributor.alternativeNameLee, Byung Seok-
dc.contributor.alternativeNameJung, Ji Ann-
dc.contributor.alternativeNameCho, Si Hyun-
dc.contributor.alternativeNameChoi, Young Sik-
dc.contributor.affiliatedAuthorKim, Hye Yeon-
dc.contributor.affiliatedAuthorSeo, Seok Kyo-
dc.contributor.affiliatedAuthorLee, Byung Seok-
dc.contributor.affiliatedAuthorJung, Ji Ann-
dc.contributor.affiliatedAuthorCho, Si Hyun-
dc.contributor.affiliatedAuthorChoi, Young Sik-
dc.rights.accessRightsfree-
dc.citation.volume93-
dc.citation.number1-
dc.citation.startPage38-
dc.citation.endPage44-
dc.identifier.bibliographicCitationACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.93(1) : 38-44, 2014-
dc.identifier.rimsid54887-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.